LOCUS Y14737 1673 bp mRNA linear HUM 19-AUG-1998
DEFINITION Homo sapiens mRNA for immunoglobulin lambda heavy chain.
ACCESSION Y14737
VERSION Y14737.1
KEYWORDS constant region; IgG1; immunoglobulin; lambda heavy chain; variable
region.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Paterson T., Innes J., McMillan L., Downing I., McCann Carter M.C.
TITLE Variation in IgG1 heavy chain allotype does not contribute to
differences in biological activity of two human anti-Rhesus (D)
monoclonal antibodies
JOURNAL Immunotechnology 4(1), 37-47(1998).
PUBMED 9661813
REFERENCE 2 (bases 1 to 1673)
AUTHORS Paterson T.
JOURNAL Submitted (03-SEP-1997) to the INSDC. T. Paterson, National Science
Laboratory, Scottish Nat. Blood Transfusion Service, 12 Bristo
Place, Edinburgh, EH1 1EZ, Scotland, UK
FEATURES Location/Qualifiers
source 1..1673
/db_xref="H-InvDB:HIT000325835"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="human /mouse (NS-0) hetero-hybridoma cell line
LHM70/45.3 (THERAD 06)"
/db_xref="taxon:9606"
sig_peptide 66..122
CDS 66..1499
/gene="IgG1L"
/product="immunoglobulin lambda heavy chain"
/db_xref="H-InvDB:HIT000325835.14"
/protein_id="CAA75032.1"
/translation="MEFGLSWVFLVALLRGVQCQVQLVESGGGVVQPGRSLRLSCAAS
GFTFSNYGMHWVRQAPGKGLEWVAAIWYDGSNKYYADSVKGRFTISRDNSKNTLYMQM
NSLRAEDTAVYYCAREGRWVRYTTVTTIGYYFDYWGQGTLVTVSSASTKGPSVFPLAP
SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTV
PSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK
PKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVS
VLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ
VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG
NVFSCSVMHEALHNHYTQKSLSLSPGK"
mat_peptide 123..1496
/product="immunoglobulin lambda heavy chain"
V_region 123..509
/product="immunoglobulin lambda heavy chain variable
region"
C_region 510..1499
/product="immunoglobulin lambda heavy chain constant
region"
BASE COUNT 413 a 508 c 452 g 300 t
ORIGIN
1 agcccagcac tagaagtcgg cggtgtttcc attcggtgat cagcactgaa cacagaggac
61 tcaccatgga gtttgggctg agctgggttt tcctcgttgc tcttttaaga ggtgtccagt
121 gtcaggtgca gctggtggag tctgggggag gcgtggtcca gcctgggagg tccctgagac
181 tctcctgtgc agcgtctgga ttcaccttca gtaattatgg catgcactgg gtccgccagg
241 ctccaggcaa ggggctggag tgggtggcag ctatatggta tgatggaagt aataaatact
301 atgcagactc cgtgaagggc cgattcacca tctccagaga caattccaag aacacgttgt
361 atatgcaaat gaacagcctg agagccgagg acacggctgt gtattattgt gcgagagagg
421 gtcggtgggt acgatatact acggtgacta ctatcggata ctactttgac tactggggcc
481 agggaaccct ggtcaccgtc tcctcagcct ccaccaaggg cccatcggtc ttccccctgg
541 caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact
601 acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca
661 ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc
721 cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca
781 ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt
841 gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg
901 acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg
961 aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga
1021 caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
1081 tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc
1141 cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt
1201 acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg
1261 tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga
1321 acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctatagca
1381 agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
1441 atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtccccg ggtaaatgag
1501 tgcgacggcc ggcaagcccc cgctccccgg gctctcgcgg tcgcacgagg atgcttggca
1561 cgtaccccgt ctacatactt cccaggcacc cagcatggaa ataaagcacc caccactgcc
1621 ctgggccctg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//