LOCUS Y00638 4315 bp mRNA linear HUM 21-OCT-2008 DEFINITION Human mRNA for leukocyte common antigen (T200). ACCESSION Y00638 VERSION Y00638.1 KEYWORDS leukocyte common antigen. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4315) AUTHORS Saito H. JOURNAL Submitted (07-OCT-1987) to the INSDC. Saito H., Dana-Farber Cancer Institute, 44 Binney Street, Boston MA 02115. REFERENCE 2 (bases 1 to 4315) AUTHORS Streuli M., Hall L.R., Saga Y., Schlossman S.F., Saito H. TITLE Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens JOURNAL J. Exp. Med. 166(5), 1548-1566(1987). PUBMED 2824653 COMMENT The protein has various names: T200, B220 and CD45. Differential usage of three exons of the human LCA gene yields at least five different mRNAs thereby generating the diversity of LCA proteins. FEATURES Location/Qualifiers source 1..4315 /db_xref="H-InvDB:HIT000325298" /organism="Homo sapiens" /chromosome="chromosome 1" /mol_type="mRNA" /clone="LCA6/2" /tissue_type="tonsil lymphocytes" /db_xref="taxon:9606" CDS 87..4001 /note="LCA (AA -23 to 1281)" /db_xref="GOA:P08575" /db_xref="H-InvDB:HIT000325298.13" /db_xref="HGNC:HGNC:9666" /db_xref="InterPro:IPR000242" /db_xref="InterPro:IPR000387" /db_xref="InterPro:IPR003595" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR016130" /db_xref="InterPro:IPR016335" /db_xref="InterPro:IPR024739" /db_xref="InterPro:IPR029021" /db_xref="InterPro:IPR036116" /db_xref="PDB:1YGR" /db_xref="PDB:1YGU" /db_xref="PDB:5FMV" /db_xref="PDB:5FN6" /db_xref="PDB:5FN7" /db_xref="UniProtKB/Swiss-Prot:P08575" /protein_id="CAA68669.1" /translation="MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLS SDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSV QTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDP VSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIA TTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKN ASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQ NITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGE PQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPY TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRD RNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFIL HHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQ LMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV NKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFG ETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRN SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVM IAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDL KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKL PQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRK ARLGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS" sig_peptide 87..155 /note="signal peptide (AA -23 to -1)" mat_peptide 156..3998 /note="mature LCA (AA 1 - 1281)" misc_feature 156..1811 /note="extracellular domain" misc_feature 1812..1877 /note="transmembrane domain" misc_feature 1878..3998 /note="cytoplasmic domain" BASE COUNT 1422 a 878 c 892 g 1123 t ORIGIN 1 ggaaattgtt cctcgtctga taagacaaca gtggagaaag gacgcatgct gtttcttagg 61 gacacggctg gcttccagat atgaccatgt atttgtggct taaactcttg gcatttggct 121 ttgcctttct ggacacagaa gtatttgtga cagggcaaag cccaacacct tcccccactg 181 gattgactac agcaaagatg cccagtgttc cactttcaag tgacccctta cctactcaca 241 ccactgcatt ctcacccgca agcacctttg aaagagaaaa tgacttctca gagaccacaa 301 cttctcttag tccagacaat acttccaccc aagtatcccc ggactctttg gataatgcta 361 gtgcttttaa taccacaggt gtttcatcag tacagacgcc tcaccttccc acgcacgcag 421 actcgcagac gccctctgct ggaactgaca cgcagacatt cagcggctcc gccgccaatg 481 caaaactcaa ccctacccca ggcagcaatg ctatctcaga tgtcccagga gagaggagta 541 cagccagcac ctttcctaca gacccagttt ccccattgac aaccaccctc agccttgcac 601 accacagctc tgctgcctta cctgcacgca cctccaacac caccatcaca gcgaacacct 661 cagatgccta ccttaatgcc tctgaaacaa ccactctgag cccttctgga agcgctgtca 721 tttcaaccac aacaatagct actactccat ctaagccaac atgtgatgaa aaatatgcaa 781 acatcactgt ggattactta tataacaagg aaactaaatt atttacagca aagctaaatg 841 ttaatgagaa tgtggaatgt ggaaacaata cttgcacaaa caatgaggtg cataacctta 901 cagaatgtaa aaatgcgtct gtttccatat ctcataattc atgtactgct cctgataaga 961 cattaatatt agatgtgcca ccaggggttg aaaagtttca gttacatgat tgtacacaag 1021 ttgaaaaagc agatactact atttgtttaa aatggaaaaa tattgaaacc tttacttgtg 1081 atacacagaa tattacctac agatttcagt gtggtaatat gatatttgat aataaagaaa 1141 ttaaattaga aaaccttgaa cccgaacatg agtataagtg tgactcagaa atactctata 1201 ataaccacaa gtttactaac gcaagtaaaa ttattaaaac agattttggg agtccaggag 1261 agcctcagat tattttttgt agaagtgaag ctgcacatca aggagtaatt acctggaatc 1321 cccctcaaag atcatttcat aattttaccc tctgttatat aaaagagaca gaaaaagatt 1381 gcctcaatct ggataaaaac ctgatcaaat atgatttgca aaatttaaaa ccttatacga 1441 aatatgtttt atcattacat gcctacatca ttgcaaaagt gcaacgtaat ggaagtgctg 1501 caatgtgtca tttcacaact aaaagtgctc ctccaagcca ggtctggaac atgactgtct 1561 ccatgacatc agataatagt atgcatgtca agtgtaggcc tcccagggac cgtaatggcc 1621 cccatgaacg ttaccatttg gaagttgaag ctggaaatac tctggttaga aatgagtcgc 1681 ataagaattg cgatttccgt gtaaaagatc ttcaatattc aacagactac acttttaagg 1741 cctattttca caatggagac tatcctggag aaccctttat tttacatcat tcaacatctt 1801 ataattctaa ggcactgata gcatttctgg catttctgat tattgtgaca tcaatagccc 1861 tgcttgttgt tctctacaaa atctatgatc tacataagaa aagatcctgc aatttagatg 1921 aacagcagga gcttgttgaa agggatgatg aaaaacaact gatgaatgtg gagccaatcc 1981 atgcagatat tttgttggaa acttataaga ggaagattgc tgatgaagga agaccttttc 2041 tggctgaatt tcagagcatc ccgcgggtgt tcagcaagtt tcctataaag gaagctcgaa 2101 agccctttaa ccagaataaa aaccgttatg ttgacattct tccttatgat tataaccgtg 2161 ttgaactctc tgagataaac ggagatgcag ggtcaaacta cataaatgcc agctatattg 2221 atggtttcaa agaacccagg aaatacattg ctgcacaagg tcccagggat gaaactgttg 2281 atgatttctg gaggatgatt tgggaacaga aagccacagt tattgtcatg gtcactcgat 2341 gtgaagaagg aaacaggaac aagtgtgcag aatactggcc gtcaatggaa gagggcactc 2401 gggcttttgg agatgttgtt gtaaagatca accagcacaa aagatgtcca gattacatca 2461 ttcagaaatt gaacattgta aataaaaaag aaaaagcaac tggaagagag gtgactcaca 2521 ttcagttcac cagctggcca gaccacgggg tgcctgagga tcctcacttg ctcctcaaac 2581 tgagaaggag agtgaatgcc ttcagcaatt tcttcagtgg tcccattgtg gtgcactgca 2641 gtgctggtgt tgggcgcaca ggaacctata tcggaattga tgccatgcta gaaggcttgg 2701 aagccgagaa caaagtggat gtttatggtt atgttgtcaa gctaaggcga cagagatgcc 2761 tgatggttca agtagaggcc cagtacatct tgatccatca ggctttggtg gaatacaatc 2821 agtttggaga aacagaagtg aatttgtctg aattacatcc atatctacat aacatgaaga 2881 aaagggatcc acccagtgag ccgtctccac tagaggctga attccagaga cttccttcat 2941 ataggagctg gaggacacag cacattggaa atcaagaaga aaataaaagt aaaaacagga 3001 attctaatgt catcccatat gactataaca gagtgccact taaacatgag ctggaaatga 3061 gtaaagagag tgagcatgat tcagatgaat cctctgatga tgacagtgat tcagaggaac 3121 caagcaaata catcaatgca tcttttataa tgagctactg gaaacctgaa gtgatgattg 3181 ctgctcaggg accactgaag gagaccattg gtgacttttg gcagatgatc ttccaaagaa 3241 aagtcaaagt tattgttatg ctgacagaac tgaaacatgg agaccaggaa atctgtgctc 3301 agtactgggg agaaggaaag caaacatatg gagatattga agttgacctg aaagacacag 3361 acaaatcttc aacttatacc cttcgtgtct ttgaactgag acattccaag aggaaagact 3421 ctcgaactgt gtaccagtac caatatacaa actggagtgt ggagcagctt cctgcagaac 3481 ccaaggaatt aatctctatg attcaggtcg tcaaacaaaa acttccccag aagaattcct 3541 ctgaagggaa caagcatcac aagagtacac ctctactcat tcactgcagg gatggatctc 3601 agcaaacggg aatattttgt gctttgttaa atctcttaga aagtgcggaa acagaagagg 3661 tagtggatat ttttcaagtg gtaaaagctc tacgcaaagc taggctaggc atggtttcca 3721 cattcgagca atatcaattc ctatatgacg tcattgccag cacctaccct gctcagaatg 3781 gacaagtaaa gaaaaacaac catcaagaag ataaaattga atttgataat gaagtggaca 3841 aagtaaagca ggatgctaat tgtgttaatc cacttggtgc cccagaaaag ctccctgaag 3901 caaaggaaca ggctgaaggt tctgaaccca cgagtggcac tgaggggcca gaacattctg 3961 tcaatggtcc tgcaagtcca gctttaaatc aaggttcata ggaaaagaca taaatgagga 4021 aactccaaac ctcctgttag ctgttatttc tatttttgta gaagtaggaa gtgaaaatag 4081 gtatacagtg gattaattaa atgcagcgaa ccaatatttg tagaagggtt atattttact 4141 actgtggaaa aatatttaag atagttttgc cagaacagtt tgtacagacg tatgcttatt 4201 ttaaaatttt atctcttatt cagtaaaaaa caacttcttt gtaatcgtta tgagtgtata 4261 tgtatgtgtg tatgggtgtg tgtttgtgtg agagacagag aaagagagag aattc //