LOCUS X98032 2559 bp mRNA linear HUM 29-APR-1997
DEFINITION H.sapiens mRNA for E6-AP isoform-I.
ACCESSION X98032
VERSION X98032.1
KEYWORDS E6-AP gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Yamamoto Y., Huibregtse J.M., Howley P.M.
TITLE The human E6-AP gene (UBE3A) encodes three potential protein
isoforms generated by differential splicing
JOURNAL Genomics 41(2), 263-266(1997).
PUBMED 9143503
REFERENCE 2 (bases 1 to 2559)
AUTHORS Yamamoto Y.
JOURNAL Submitted (13-MAY-1996) to the INSDC. Y. Yamamoto, Harvard Medical
School, Pathology, 200 Longwood Ave. Boston, MA. 02115, USA
FEATURES Location/Qualifiers
source 1..2559
/db_xref="H-InvDB:HIT000325030"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="primary keratinocyte"
/db_xref="taxon:9606"
CDS 1..2559
/gene="E6-AP"
/note="isoform I"
/db_xref="GOA:Q05086"
/db_xref="H-InvDB:HIT000325030.12"
/db_xref="HGNC:HGNC:12496"
/db_xref="InterPro:IPR000569"
/db_xref="InterPro:IPR017134"
/db_xref="InterPro:IPR032353"
/db_xref="InterPro:IPR035983"
/db_xref="InterPro:IPR042556"
/db_xref="PDB:1C4Z"
/db_xref="PDB:1D5F"
/db_xref="PDB:1EQX"
/db_xref="PDB:2KR1"
/db_xref="PDB:4GIZ"
/db_xref="PDB:4XR8"
/db_xref="UniProtKB/Swiss-Prot:Q05086"
/protein_id="CAA66655.1"
/translation="MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNA
AAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDV
TYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA
KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRR
VYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIGMENRNLHSP
EYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFN
SRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE
ERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN
KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDH
IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGM
FTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGT
FRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPI
TNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR
NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLG
KLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML"
BASE COUNT 853 a 443 c 556 g 707 t
ORIGIN
1 atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc
61 tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg
121 gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt
181 gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc
241 cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa
301 gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga
361 gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg
421 gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca
481 aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg
541 gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat
601 ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac
661 accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg
721 tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat
781 ctgaatttgt tcattatcgg aatggagaat agaaatctcc acagtcctga atatctggaa
841 atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa
901 ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt
961 cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat
1021 gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta
1081 gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag
1141 tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct
1201 cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt
1261 atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat
1321 tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata
1381 ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt
1441 gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg
1501 agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc
1561 gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa
1621 ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc
1681 aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca
1741 tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt
1801 tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg
1861 aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa
1921 gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca
1981 cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt
2041 ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat
2101 aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa
2161 tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg
2221 aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac
2281 tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga
2341 ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta
2401 aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc
2461 tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg
2521 aaggccatca cgtatgccaa aggatttggc atgctgtaa
//