LOCUS X63717 2551 bp mRNA linear HUM 19-JUL-1996
DEFINITION H.sapiens mRNA for APO-1 cell surface antigen.
ACCESSION X63717
VERSION X63717.1
KEYWORDS APO-1 gene; cell surface antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2551)
AUTHORS Krammer P.H.
JOURNAL Submitted (10-FEB-1992) to the INSDC. P.H. Krammer, German Cancer
Research Center, Tumorimmunology Program, Im Neuenheimer Feld 280,
6900 Heidelberg, FRG
REFERENCE 2 (bases 1 to 2551)
AUTHORS Oehm A., Behrmann I., Falk W., Pawlita M., Maier G., Li-Weber M.,
Richards S., Dhein J., Trauth B.C., Postingl H., Krammer P.H.
TITLE Purification and molecular cloning of the APO-1 cell surface
antigen, a member of the tumor necrosis factor/nerve growth factor
receptor superfamily. Sequence identity with the Fas antigen
JOURNAL J Biol Chem 267(15), 10709-10715(1992).
PUBMED 1375228
FEATURES Location/Qualifiers
source 1..2551
/db_xref="H-InvDB:HIT000322625"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="14"
/cell_line="SKW6.4"
/db_xref="taxon:9606"
CDS 221..1228
/gene="APO-1"
/product="APO-1 cell surface antigen precursor"
/db_xref="GOA:P25445"
/db_xref="H-InvDB:HIT000322625.14"
/db_xref="HGNC:HGNC:11920"
/db_xref="InterPro:IPR000488"
/db_xref="InterPro:IPR001368"
/db_xref="InterPro:IPR008063"
/db_xref="InterPro:IPR011029"
/db_xref="InterPro:IPR033998"
/db_xref="InterPro:IPR033999"
/db_xref="PDB:1BZI"
/db_xref="PDB:1DDF"
/db_xref="PDB:2NA7"
/db_xref="PDB:3EWT"
/db_xref="PDB:3EZQ"
/db_xref="PDB:3THM"
/db_xref="PDB:3TJE"
/db_xref="UniProtKB/Swiss-Prot:P25445"
/protein_id="CAA45250.1"
/translation="MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTV
ETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCR
RCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLT
SNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPE
TVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQ
LLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSL
V"
sig_peptide 221..268
/gene="APO-1"
mat_peptide 269..1225
/gene="APO-1"
/product="APO-1 cell surface antigen"
regulatory 1857..1862
/regulatory_class="polyA_signal_sequence"
regulatory 2378..2383
/regulatory_class="polyA_signal_sequence"
regulatory 2544..2549
/regulatory_class="polyA_signal_sequence"
BASE COUNT 826 a 493 c 508 g 724 t
ORIGIN
1 gcaagagtga cacacaggtg ttcaaagacg cttctgggga gtgagggaag cggtttacga
61 gtgacttggc tggagcctca ggggcgggca ctggcacgga acacaccctg aggccagccc
121 tggctgccca ggcggagctg cctcttctcc cgcgggttgg tggacccgct cagtacggag
181 ttggggaagc tctttcactt cggaggattg ctcaacaacc atgctgggca tctggaccct
241 cctacctctg gttcttacgt ctgttgctag attatcgtcc aaaagtgtta atgcccaagt
301 gactgacatc aactccaagg gattggaatt gaggaagact gttactacag ttgagactca
361 gaacttggaa ggcctgcatc atgatggcca attctgccat aagccctgtc ctccaggtga
421 aaggaaagct agggactgca cagtcaatgg ggatgaacca gactgcgtgc cctgccaaga
481 agggaaggag tacacagaca aagcccattt ttcttccaaa tgcagaagat gtagattgtg
541 tgatgaagga catggcttag aagtggaaat aaactgcacc cggacccaga ataccaagtg
601 cagatgtaaa ccaaactttt tttgtaactc tactgtatgt gaacactgtg acccttgcac
661 caaatgtgaa catggaatca tcaaggaatg cacactcacc agcaacacca agtgcaaaga
721 ggaaggatcc agatctaact tggggtggct ttgtcttctt cttttgccaa ttccactaat
781 tgtttgggtg aagagaaagg aagtacagaa aacatgcaga aagcacagaa aggaaaacca
841 aggttctcat gaatctccaa ccttaaatcc tgaaacagtg gcaataaatt tatctgatgt
901 tgacttgagt aaatatatca ccactattgc tggagtcatg acactaagtc aagttaaagg
961 ctttgttcga aagaatggtg tcaatgaagc caaaatagat gagatcaaga atgacaatgt
1021 ccaagacaca gcagaacaga aagttcaact gcttcgtaat tggcatcaac ttcatggaaa
1081 gaaagaagcg tatgacacat tgattaaaga tctcaaaaaa gccaatcttt gtactcttgc
1141 agagaaaatt cagactatca tcctcaagga cattactagt gactcagaaa attcaaactt
1201 cagaaatgaa atccaaagct tggtctagag tgaaaaacaa caaattcagt tctgagtata
1261 tgcaattagt gtttgaaaag attcttaata gctggctgta aatactgctt ggttttttac
1321 tgggtacatt ttatcattta ttagcgctga agagccaaca tatttgtaga tttttaatat
1381 ctcatgattc tgcctccaag gatgtttaaa atctagttgg gaaaacaaac ttcatcaaga
1441 gtaaatgcag tggcatgcta agtacccaaa taggagtgta tgcagaggat gaaagattaa
1501 gattatgctc tggcatctaa catatgattc tgtagtatga atgtaatcag tgtatgttag
1561 tacaaatgtc tatccacagg ctaaccccac tctatgaatc aatagaagaa gctatgacct
1621 tttgctgaaa tatcagttac tgaacaggca ggccactttg cctctaaatt acctctgata
1681 attctagaga ttttaccata tttctaaact ttgtttataa ctctgagaag atcatattta
1741 tgtaaagtat atgtatttga gtgcagaatt taaataaggc tctacctcaa agacctttgc
1801 acagtttatt ggtgtcatat tatacaatat ttcaattgtg aattcacata gaaaacatta
1861 aattataatg tttgactatt atatatgtgt atgcatttta ctggctcaaa actacctact
1921 tctttctcag gcatcaaaag cattttgagc aggagagtat tactagagct ttgccacctc
1981 tccatttttg ccttggtgct catcttaatg gcctaatgca cccccaaaca tggaaatatc
2041 accaaaaaat acttaatagt ccaccaaaag gcaagactgc ccttagaaat tctagcctgg
2101 tttggagata ctaactgctc tcagagaaag tagctttgtg acatgtcatg aacccatgtt
2161 tgcaatcaaa gatgataaaa tagattctta tttttccccc acccccgaaa atgttcaata
2221 atgtcccatg taaaacctgc tacaaatggc agcttataca tagcaatggt aaaatcatca
2281 tctggattta ggaattgctc ttgtcatacc cccaagtttc taagatttaa gattctcctt
2341 actactatcc tacgtttaaa tatctttgaa agtttgtatt aaatgtgaat tttaagaaat
2401 aatatttata tttctgtaaa tgtaaactgt gaagatagtt ataaactgaa gcagatacct
2461 ggaaccacct aaagaacttc catttatgga ggattttttt gccccttgtg tttggaatta
2521 taaaatatag gtaaaagtac gtaattaaat a
//