LOCUS X63597 6021 bp mRNA linear HUM 05-OCT-2005
DEFINITION H.sapiens si mRNA for sucrase-isomaltase.
ACCESSION X63597 S41833
VERSION X63597.1
KEYWORDS isomaltase; pro-sucrase-isomaltase; si gene; sucrase;
sucrase-isomaltase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6021)
AUTHORS Lacasa M.
JOURNAL Submitted (27-DEC-1991) to the INSDC. M. Lacasa, Centre National de
la Recherche Scientifique, IRSC-7 Rue Guy Moquet, 94801 Villejuif
Cedex, FRANCE
REFERENCE 2 (bases 1 to 6021)
AUTHORS Chantret I., Lacasa M., Chevalier G., Ruf J., Islam I., Mantei N.,
Edwards Y., Swallow D., Rousset M.
TITLE Sequence of the complete cDNA and the 5' structure of the human
sucrase-isomaltase gene. Possible homology with a yeast
glucoamylase.
JOURNAL Biochem. J. 285, 915-923(1992).
PUBMED 1353958
COMMENT See also M22616
FEATURES Location/Qualifiers
source 1..6021
/db_xref="H-InvDB:HIT000322607"
/organism="Homo sapiens"
/chromosome="3q25-26"
/mol_type="mRNA"
/tissue_type="intestine"
/db_xref="taxon:9606"
misc_feature 63..2855
/note="isomaltase"
CDS 63..5546
/gene="si"
/product="prosucrose-isomaltase"
/EC_number="3.2.1.48"
/EC_number="3.2.1.10"
/db_xref="GOA:P14410"
/db_xref="H-InvDB:HIT000322607.15"
/db_xref="HGNC:HGNC:10856"
/db_xref="InterPro:IPR000322"
/db_xref="InterPro:IPR000519"
/db_xref="InterPro:IPR011013"
/db_xref="InterPro:IPR013780"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR017957"
/db_xref="InterPro:IPR030458"
/db_xref="InterPro:IPR030459"
/db_xref="InterPro:IPR031727"
/db_xref="PDB:3LPO"
/db_xref="PDB:3LPP"
/db_xref="UniProtKB/Swiss-Prot:P14410"
/protein_id="CAA45140.1"
/translation="MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDS
TSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSL
IPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRF
KITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIG
PLVYSDQYLQISARLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYG
HQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQV
VQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYM
EDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQ
HVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNE
VSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSM
AIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSL
FGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLV
KSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPAL
LITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIP
IQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNN
TLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVL
LIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAP
ECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDML
QFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDS
WLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNS
YGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPQV
ATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDY
MERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVF
VKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREI
VDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTI
CMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWG
GHWLGDNYARWDNMDKSIIGMMEFSLFGISYTGADICGFFNNSEYHLCTRWMQLGAFY
PYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRP
LLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVR
GQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFW
DDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNA
VTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS"
misc_feature 2856..5546
/note="sucrase"
regulatory 5992..5997
/regulatory_class="polyA_signal_sequence"
polyA_site 6009
BASE COUNT 1962 a 1127 c 1170 g 1762 t
ORIGIN
1 tattttggca gccttatcca agtctggtac aacatagcaa agagaacagg ctatgaaata
61 agatggcaag aaagaaattt agtggattgg aaatctctct gattgtcctt tttgtcatag
121 ttactataat agctattgcc ttaattgttg ttttagcaac taagacacct gctgttgatg
181 aaattagtga ttctacttca actccagcta ctactcgtgt gactacaaat ccttctgatt
241 caggaaaatg tccaaatgtg ttaaatgatc ctgtcaatgt gagaataaac tgcattccag
301 aacaattccc aacagaggga atttgtgcac agagaggctg ctgctggagg ccgtggaatg
361 actctcttat tccttggtgc ttcttcgttg ataatcatgg ttataacgtt caagacatga
421 caacaacaag tattggagtt gaagccaaat taaacaggat accttcacct acactatttg
481 gaaatgacat caacagtgtt ctcttcacaa ctcaaaatca gacacccaat cgtttccggt
541 tcaagattac tgatccaaat aatagaagat atgaagttcc tcatcagtat gtaaaagagt
601 ttactggacc cacagtttct gatacgttgt atgatgtgaa ggttgcccaa aacccattta
661 gcatccaagt tattaggaaa agcaacggta aaactttgtt tgacaccagc attggtccct
721 tagtgtactc tgaccagtac ttacagatct cagcccgtct tccaagtgat tatatttatg
781 gtattggaga acaagttcat aagagatttc gtcatgattt atcctggaaa acatggccaa
841 tttttactcg agaccaactt cctggtgata ataataataa tttatacggc catcaaacat
901 tctttatgtg tattgaagat acatctggaa agtcattcgg tgttttttta atgaatagca
961 atgcaatgga gatttttatc cagcctactc caatagtaac atatagagtt accggtggca
1021 ttctggattt ttacatcctt ctaggagata caccagaaca agtagttcaa cagtatcaac
1081 agcttgttgg actaccagca atgccagcat attggaatct tggattccaa ctaagtcgct
1141 ggaattataa gtcactagat gtagtgaaag aagtggtaag gagaaaccgg gaagctggca
1201 taccatttga tacacaggtc actgatattg actacatgga agacaagaaa gactttactt
1261 atgatcaagt tgcgtttaac ggactccctc aatttgtgca agatttgcat gaccatggac
1321 agaaatatgt catcatcttg gaccctgcaa tttccatagg tcgacgtgcc aatggaacaa
1381 catatgcaac ctatgagagg ggaaacacac aacatgtgtg gataaatgag tcagatggaa
1441 gtacaccaat tattggagag gtatggccag gattaacagt ataccctgat ttcactaatc
1501 caaactgcat tgattggtgg gcaaatgaat gcagtatttt ccatcaagaa gtgcaatatg
1561 atggactttg gattgacatg aatgaagttt ccagctttat tcaaggttca acaaaaggat
1621 gtaatgtaaa caaattgaat tatccaccgt ttactcctga tattcttgac aaactcatgt
1681 attccaaaac aatttgcatg gatgctgtgc agaactgggg taaacagtat gatgttcata
1741 gcctctatgg atacagcatg gctatagcca cagagcaagc tgtacaaaaa gtttttccta
1801 ataagagaag cttcattctt acccgctcaa catttgctgg atctggaaga catgctgctc
1861 attggttagg agacaatact gcttcatggg aacaaatgga atggtctata actggaatgc
1921 tggagttcag tttgtttgga atacctttgg ttggagcaga catctgtgga tttgtggctg
1981 aaaccacaga agaactttgc agaagatgga tgcaacttgg ggcattttat ccattttcca
2041 gaaaccataa ttctgacgga tatgaacatc aggatcctgc attttttggg cagaattcac
2101 ttttggttaa atcatcaagg cagtatttaa ctattcgcta caccttatta cccttcctct
2161 acactctgtt ttataaagcc catgtgtttg gagaaacagt agcaagacca gttcttcatg
2221 agttttatga ggatacgaac agctggattg aggacactga gtttttgtgg ggccctgcat
2281 tacttattac tcctgttcta aaacagggag cagatactgt gagtgcctac atccctgatg
2341 ctatttggta tgattatgaa tctggtgcaa aaaggccatg gaggaaacaa cgggttgata
2401 tgtatcttcc agcagacaaa ataggattac atcttagagg aggttatatc atccccattc
2461 aagaaccaga tgtaacaaca acagcaagcc gtaagaatcc tctaggactt atagtcgcat
2521 taggtgaaaa caacacagcc aaaggagact ttttctggga tgatggagaa actaaagata
2581 caatacaaaa tggcaactac atattatata cattttcagt ttctaataac acattagata
2641 ttgtgtgcac acattcatca tatcaggaag gaactacctt agcatttcag actgtaaaaa
2701 tccttgggtt gacagacagt gttacagaag ttagagtggc ggaaaataat caaccaatga
2761 acgctcattc caatttcact tatgatgctt ctaaccaggt tctcctaatt gcagatctca
2821 aacttaatct tggaagaaac tttagtgttc aatggaatca aattttctca gaaaatgaaa
2881 gatttaattg ttatccagat gcagatttgg caactgaaca aaagtgcaca caacgtggct
2941 gtgtatggag aacgggttct tctctatcca aagcacctga gtgttacttt cccagacaag
3001 ataactctta ttcagtcaac tcagctcgct attcatccat gggtataaca gctgacctcc
3061 aactaaatac tgcaaatgcc agaataaagt taccttctga ccccatctca actcttcgtg
3121 tggaggtgaa atatcacaaa aatgatatgt tgcagtttaa gatttatgat ccccaaaaga
3181 agagatatga agtaccagta ccgttaaaca ttccaaccac cccaataagt acttatgaag
3241 acagacttta tgatgtggaa atcaaggaaa atccttttgg catccagatt cgacggagaa
3301 gcagtggaag agtcatttgg gattcttggc tgcctggatt tgcttttaat gaccagttca
3361 ttcaaatatc gactcgcctg ccatcagaat atatatatgg ttttggggaa gtggaacata
3421 cagcatttaa gcgagatctg aactggaata cttggggaat gttcacaaga gaccaacccc
3481 ctggttacaa acttaattcc tatggatttc atccctatta catggctctg gaagaggagg
3541 gcaatgctca tggtgttttc ttactcaaca gcaatgcaat ggatgttaca ttccagccaa
3601 ctcctgctct aacttaccgt acagttggag ggatcttgga tttttatatg tttttgggcc
3661 caactccaca agttgcaaca aagcaatacc atgaagtaat tggccatcca gtcatgccag
3721 cttattgggc tttgggattc caattatgtc gttatggata tgcaaatact tcagaggttc
3781 gggaattata tgacgctatg gtggctgcta acatccccta tgatgttcag tacacagaca
3841 ttgactacat ggaaaggcag ctagacttta caattggtga agcattccag gaccttcctc
3901 agtttgttga caaaataaga ggagaaggaa tgagatacat tattatcctg gatccagcaa
3961 tttcaggaaa tgaaacaaag acttaccctg catttgaaag aggacagcag aatgatgtct
4021 ttgtcaaatg gccaaacacc aatgacattt gttgggcaaa ggtttggcca gatttgccca
4081 acataacaat agataaaact ctaacggaag atgaagctgt taatgcttcc agagctcatg
4141 tagctttccc agatttcttc aggacttcca cagcagagtg gtgggccaga gaaattgtgg
4201 acttttacaa tgaaaagatg aagtttgatg gtttgtggat tgatatgaat gagccatcaa
4261 gttttgtaaa tggaacaact actaatcaat gcagaaatga cgaactaaat tatccacctt
4321 atttcccaga actcacaaaa agaactgatg gattacattt cagaacaatt tgcatggaag
4381 ctgagcagat tcttagtgat ggaacatcag ttttgcatta cgatgttcac aatctctatg
4441 gatggtcaca gatgaaacct actcatgatg cattgcaaaa gacaactgga aaaagaggga
4501 ttgtaatttc tcgttccacg tatcctacta gtggacgatg gggaggacac tggcttggag
4561 acaactatgc acgatgggac aacatggaca aatcaatcat tggtatgatg gaatttagtc
4621 tgtttggaat atcatatact ggagcagaca tctgtggttt tttcaacaac tcagaatatc
4681 atctctgtac ccgctggatg caacttggag cattttatcc atactcaagg aatcacaaca
4741 ttgcaaatac tagaagacaa gatcccgctt cctggaatga aacttttgct gaaatgtcaa
4801 ggaatattct aaatattaga tacaccttat tgccctattt ttacacacaa atgcatgaaa
4861 ttcatgctaa tggtggcact gttatccgac cccttttgca tgagttcttt gatgaaaaac
4921 caacctggga tatattcaag cagttcttat ggggtccagc atttatggtt accccagtac
4981 tggaacctta tgttcaaact gtaaatgcct acgtccccaa tgctcggtgg tttgactacc
5041 atacaggcaa agatattggc gtcagaggac aatttcaaac atttaatgct tcttatgaca
5101 caataaacct acatgtccgt ggtggtcaca tcctaccatg tcaagagcca gctcaaaaca
5161 cattttacag tcgacaaaaa cacatgaagc tcattgttgc tgcagatgat aatcagatgg
5221 cacagggttc tctgttttgg gatgatggag agagtataga cacctatgaa agagacctat
5281 atttatctgt acaatttaat ttaaaccaga ccaccttaac aagcactata ttgaagagag
5341 gttacataaa taaaagtgaa acgaggcttg gatcccttca tgtatggggg aaaggaacta
5401 ctcctgtcaa tgcagttact ctaacgtata acggaaataa aaattcgctt ccttttaatg
5461 aagacactac caacatgata ttacgtattg atctgaccac acacaatgtt actctagaag
5521 aaccaataga aatcaactgg tcatgaagat caccatcaat tttagttgtc aatgggaaaa
5581 aacaccagga tttaagtttc acagcactta caattttccc tcttcacttg gttcttgtac
5641 tctacaaaat atagctttca taacatcgaa aagttatttt gtagcgtaca tcaatgataa
5701 tgctaatttt attatagtaa tgtgacttgg attcaatttt aaggcatatt taacaaaatt
5761 tgaatagccc tatttatcct tgttaagtat cagctacaat tgtaaactag ttactaaaca
5821 tgtatgtaaa tagctaagat ataatttaaa cgtgattttt aaattaaata aaatttttat
5881 gtaattatat atactatatt tttctcaatg tttagcagat ttaagatatg taacaacaat
5941 tatttgaaga tttaattact tcttagtatg tgcatttaat tagaaaaaga gaataaaaaa
6001 tgtaagtgta aaaaaaaaaa a
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