LOCUS X06115 4362 bp mRNA linear ROD 21-OCT-2008
DEFINITION Mouse mRNA for E-cadherin (= uvomorulin, = L-CAM, = cell-CAM
120/80, = Arc-1).
ACCESSION X06115
VERSION X06115.1
KEYWORDS cadherin; calcium binding protein; cell adhesion molecule; cell
surface glycoprotein; glycoprotein; transmembrane protein;
uvomorulin.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4362)
AUTHORS Nagafuchi A., Shirayoshi Y., Okazari K., Yasuda K., Takeichi M.
TITLE Transformation of cell adhesion properties by exogenously
introduced E-cadherin cDNA
JOURNAL Nature 329(6137), 341-343(1987).
PUBMED 3498123
COMMENT The sequence overlaps with that reported by Ringwald et. al.
in EMBO J. 6:3647-3653(1987), X06339.
FEATURES Location/Qualifiers
source 1..4362
/organism="Mus musculus"
/strain="ICR"
/mol_type="mRNA"
/dev_stage="newborn"
/clone_lib="lambda gt11"
/clone="lambda 13, lambda 21."
/cell_line="F9"
/tissue_type="liver"
/db_xref="taxon:10090"
CDS 69..2723
/note="E-cadherin precursor (AA -156 to 884)"
/db_xref="GOA:P09803"
/db_xref="InterPro:IPR000233"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR014868"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="InterPro:IPR039808"
/db_xref="MGI:MGI:88354"
/db_xref="PDB:1EDH"
/db_xref="PDB:1FF5"
/db_xref="PDB:1I7W"
/db_xref="PDB:1I7X"
/db_xref="PDB:1Q1P"
/db_xref="PDB:1SUH"
/db_xref="PDB:2OMW"
/db_xref="PDB:2QVF"
/db_xref="PDB:3IFQ"
/db_xref="PDB:3LNE"
/db_xref="PDB:3LNF"
/db_xref="PDB:3LNG"
/db_xref="PDB:3LNH"
/db_xref="PDB:3LNI"
/db_xref="PDB:3Q2L"
/db_xref="PDB:3Q2N"
/db_xref="PDB:3Q2V"
/db_xref="PDB:3QRB"
/db_xref="PDB:4QD2"
/db_xref="UniProtKB/Swiss-Prot:P09803"
/protein_id="CAA29488.1"
/translation="MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVP
ERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLV
RARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVI
PPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKV
TQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEG
AVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSG
LDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVN
ARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQ
QYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEIT
SYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVAL
IIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPN
TSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTT
LDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVK
EPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQ
YRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESD
QDQDYDYLNEWGNRFKKLADMYGGGEDD"
mat_peptide 537..2720
/note="mature E-cadherin (AA 1-728)"
misc_feature 537..2165
/note="extracellular domain"
misc_feature 2166..2267
/note="transmembrane domain"
misc_feature 2268..2720
/note="cytoplasmic domain"
BASE COUNT 1121 a 1102 c 1102 g 1037 t
ORIGIN
1 ccggcctaac ccggccctgc ccgaccgcac ccgagctcag tgtttgctcg gcgtctgccg
61 ggtccgccat gggagcccgg tgccgcagct tttccgcgct cctgctcctg ctgcaggtct
121 cctcatggct ttgccaggag ctggagcctg agtcctgcag tcccggcttc agttccgagg
181 tctacacctt cccggtgccg gagaggcacc tggagagagg ccatgtcctg ggcagagtga
241 gatttgaagg atgcaccggc cggccaagga cagccttctt ttcggaagac tcccgattca
301 aagtggcgac agacggcacc atcacagtga agcggcatct aaagctccac aagctggaga
361 ccagtttcct cgtccgcgcc cgggactcca gtcataggga gctgtctacc aaagtgacgc
421 tgaagtccat ggggcaccac catcaccggc accaccaccg cgaccctgcc tctgaatcca
481 acccagagct gctcatgttt cccagcgtgt acccaggtct cagaagacag aaacgagact
541 gggtcatccc tcccatcagc tgccccgaaa atgaaaaggg tgaattccca aagaacctgg
601 ttcagatcaa atccaacagg gacaaagaaa caaaggtttt ctacagcatc accggccaag
661 gagctgacaa accccccgtt ggcgttttca tcattgagag ggagacaggc tggctgaaag
721 tgacacagcc tctggataga gaagccattg ccaagtacat cctctattct catgccgtgt
781 catcaaatgg ggaagcggtg gaggatccca tggagatagt gatcacagtg acagatcaga
841 atgacaacag gccagagttt acccaggagg tgtttgaggg atccgttgca gaaggcgctg
901 ttccaggaac ctccgtgatg aaggtctcag ccaccgatgc agacgatgac gtcaacacct
961 acaacgctgc catcgcctac accatcgtca gccaggatcc tgagctgcct cacaaaaaca
1021 tgttcactgt caatagggac accggggtca tcagtgtgct cacctctggg ctggaccgag
1081 agagttaccc tacatacact ctggtggttc aggctgctga ccttcaaggc gaaggcttga
1141 gcacaacagc caaggctgtg atcactgtca aggatattaa tgacaacgct cctgtcttca
1201 acccgagcac gtatcagggt caagtgcctg agaatgaggt caatgcccgg atcgccacac
1261 tcaaagtgac cgatgatgat gcccccaaca ctccggcgtg gaaagctgtg tacaccgtag
1321 tcaacgatcc tgaccagcag ttcgttgtcg tcacagaccc cacgaccaat gatggcattt
1381 tgaaaacagc caagggcttg gattttgagg ccaagcagca atacatcctt catgtgagag
1441 tggagaacga ggaacccttt gaggggtctc ttgtcccttc cacagccact gtcactgtgg
1501 acgtggtaga cgtgaatgaa gcccccatct ttatgcctgc ggagaggaga gtcgaagtgc
1561 ccgaagactt tggtgtgggt caggaaatca catcttatac cgctcgagag ccggacacgt
1621 tcatggatca gaagatcacg tatcggattt ggagggacac tgccaactgg ctggagatta
1681 acccagagac tggtgccatt ttcacgcgcg ctgagatgga cagagaagac gctgagcatg
1741 tgaagaacag cacatatgta gctctcatca tcgccacaga tgatggttca cccattgcca
1801 ctggcacggg cactcttctc ctggtcctgt tagacgtcaa tgacaacgct cccatcccag
1861 aacctcgaaa catgcagttc tgccagagga acccacagcc tcatatcatc accatcttgg
1921 atccagacct tccccccaac acgtccccct ttactgctga gctaacccat ggggccagcg
1981 tcaactggac cattgagtat aatgacgcag ctcaagaatc tctcattttg caaccaagaa
2041 aggacttaga gattggcgaa tacaaaatcc atctcaagct cgcggataac cagaacaaag
2101 accaggtgac cacgttggac gtccatgtgt gtgactgtga agggacggtc aacaactgca
2161 tgaaggcggg aatcgtggca gcaggattgc aagttcctgc catcctcgga atccttggag
2221 ggatcctcgc cctgctgatt ctgatcctgc tgctcctact gtttctacgg aggagaacgg
2281 tggtcaaaga gcccctgctg ccaccagatg atgatacccg ggacaatgtg tattactatg
2341 atgaagaagg aggtggagaa gaagaccagg actttgattt gagccagctg cacaggggcc
2401 tggatgcccg accggaagtg actcgaaatg atgtggctcc caccctcatg agcgtgcccc
2461 agtatcgtcc ccgtcctgcc aatcctgatg aaattggaaa cttcatcgat gaaaacctga
2521 aggcagccga cagcgacccc acggcacccc cttacgactc tctgttggtg ttcgattacg
2581 agggcagtgg ttctgaagcc gctagcctga gctcactgaa ctcctctgag tcggatcagg
2641 accaggacta cgattatctg aacgagtggg gcaaccgatt caagaagctg gcggacatgt
2701 acggcggtgg cgaggacgac taggggacta gcaagtctcc cccgtgtggc accatgggag
2761 atgcagaata attatatcag tggtctttcc agctccttcc ctgagtgtgt agaagagaga
2821 ctgatctgag aagtgtgcag attgcatagt ggtctcactc tccctactgg actgtctgtg
2881 ttaggatggt tttcactgat tgttgaaatc tttttttatt ttttattttt acagtgctga
2941 gatataaact gtgccttttt ttgtttgttt gtttctgttt ttgttctttt gagctatgat
3001 ctgccccaga cacaacagcc ccaagcccct cacacctcac taatttttta cattgtgtac
3061 ttgccctcaa ttaccatgtt tgctgtattc taatagtcac tcatgttcct gaattctgtt
3121 gccctgccca ggtgatattc taggatgcag aaatgcctgg gcccttttat ggtgagagac
3181 aggtatcttg gtgtgggtgc aactgcgctg gatagtgtgt gtgttcccaa gatctttcgt
3241 ggtattccct ctccacctcc agagaactca tttacagtgg cattccttgt tcggctatgt
3301 gtctggggca gaacaaaaaa aagggaccac tatgcatgct gcacacgtct cagattctta
3361 ggtacacacc tgattcttag gtgcatgcca tagtgggata tgttgctttg atcagaacct
3421 gcagggaggt tttcgggcac cacttaagtt tcttggcgtt tctttcaaac caaaactaaa
3481 gaatggttgt tctctgagag agactggagt gccaccacca aagacagagg agagaaaagg
3541 agagaaacca aacttgggga cagcaacatc agcgaacccg gctagttggc acaccgatgg
3601 tgagggtaca caggcggtga gacctatccc acaagatttc tggaagacta ggcttatctc
3661 aaccaatgtt ttctggctgg aatctttgtc catgtattcc tgaagcccag gaaatgcacc
3721 cctccaatgc ctgctcttga tggtagctac agaaaatgct ggccgattta aacccaagtt
3781 gcccagttct gagtagaaaa ctgagactat gctgtgtgtg gcggcgcgca cctttaagcc
3841 cagcactcag gaggcagagg cagtcagatc tccctgagtt cgaggccaac ctggtatata
3901 tagtatagta agcgaattct aggacaacca gggctacaca gagaaaccct gtctctgcaa
3961 accaaaagag aaaactgaga atattacaaa ttgtgcattt tctcaggaag caggaagaga
4021 acattctaac gggaaaaagg agacaagacc tttgagagtt ttcattcaaa atgcaaatct
4081 cagctttttg ataaccactg gaaagaattt tattgaaagt tctgtactta cctaactttg
4141 gaagaaaatg atgaccacaa tcaactgtga gaactgttga tttctctgta gtttaatcat
4201 gtaatgttgc tagagtgacc tttgtatgta gtttgagtgt atgtgtgtgg gtgctgataa
4261 ttttgtattt tgtggggggt ggaaaaggta agccattgaa accgttctct aagatgcatt
4321 tttatgaatt ttattaaaga gttttgttaa actgtaaaaa aa
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