LOCUS       HSU93051                1212 bp    mRNA    linear   HUM 01-APR-1997
DEFINITION  Human putative protein tyrosine phosphatase (PTEN) mRNA, complete
            cds.
ACCESSION   U93051
VERSION     U93051.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Li,J., Yen,C., Liaw,D., Podsypanina,K., Bose,S., Wang,S.I., Puc,J.,
            Miliaresis,C., Rodgers,L., McCombie,R., Bigner,S.H.,
            Giovanella,B.C., Ittmann,M., Tycko,B., Hibshoosh,H., Wigler,M.H.
            and Parsons,R.
  TITLE     PTEN, a putative protein tyrosine phosphatase gene mutated in human
            brain, breast, and prostate cancer
  JOURNAL   Science 275 (5308), 1943-1947 (1997)
   PUBMED   9072974
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Li,J., Yen,C., Liaw,D., Podsypanina,K., Bose,S., Wang,S.I., Puc,J.,
            Miliaresis,C., Rodgers,L., McCombie,R., Bigner,S.H.,
            Giovanella,B.C., Ittmann,M., Tycko,B., Hibshoosh,H., Wigler,M.H.
            and Parsons,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-1997) Pathology, Columbia University, 630 W.
            168th Street, New York, NY 10032, USA
FEATURES             Location/Qualifiers
     source          1..1212
                     /db_xref="H-InvDB:HIT000222658"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23"
     gene            1..1212
                     /gene="PTEN"
     CDS             1..1212
                     /gene="PTEN"
                     /note="protein tyrosine phosphatase and tensin homolog;
                     candidate tumor suppressor"
                     /codon_start=1
                     /product="putative protein tyrosine phosphatase"
                     /protein_id="AAC51183.1"
                     /translation="MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEG
                     VYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK
                     PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT
                     RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC
                     QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVN
                     TFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN
                     RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
                     DEDQHTQITKV"
BASE COUNT          428 a          222 c          244 g          318 t
ORIGIN      
        1 atgacagcca tcatcaaaga gatcgttagc agaaacaaaa ggagatatca agaggatgga
       61 ttcgacttag acttgaccta tatttatcca aacattattg ctatgggatt tcctgcagaa
      121 agacttgaag gcgtatacag gaacaatatt gatgatgtag taaggttttt ggattcaaag
      181 cataaaaacc attacaagat atacaatctt tgtgctgaaa gacattatga caccgccaaa
      241 tttaattgca gagttgcaca atatcctttt gaagaccata acccaccaca gctagaactt
      301 atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg aagatgacaa tcatgttgca
      361 gcaattcact gtaaagctgg aaagggacga actggtgtaa tgatatgtgc atatttatta
      421 catcggggca aatttttaaa ggcacaagag gccctagatt tctatgggga agtaaggacc
      481 agagacaaaa agggagtaac tattcccagt cagaggcgct atgtgtatta ttatagctac
      541 ctgttaaaga atcatctgga ttatagacca gtggcactgt tgtttcacaa gatgatgttt
      601 gaaactattc caatgttcag tggcggaact tgcaatcctc agtttgtggt ctgccagcta
      661 aaggtgaaga tatattcctc caattcagga cccacacgac gggaagacaa gttcatgtac
      721 tttgagttcc ctcagccgtt acctgtgtgt ggtgatatca aagtagagtt cttccacaaa
      781 cagaacaaga tgctaaaaaa ggacaaaatg tttcactttt gggtaaatac attcttcata
      841 ccaggaccag aggaaacctc agaaaaagta gaaaatggaa gtctatgtga tcaagaaatc
      901 gatagcattt gcagtataga gcgtgcagat aatgacaagg aatatctagt acttacttta
      961 acaaaaaatg atcttgacaa agcaaataaa gacaaagcca accgatactt ttctccaaat
     1021 tttaaggtga agctgtactt cacaaaaaca gtagaggagc cgtcaaatcc agaggctagc
     1081 agttcaactt ctgtaacacc agatgttagt gacaatgaac ctgatcatta tagatattct
     1141 gacaccactg actctgatcc agagaatgaa ccttttgatg aagatcagca tacacaaatt
     1201 acaaaagtct ga
//