LOCUS       HSU92436                3160 bp    mRNA    linear   HUM 01-APR-1997
DEFINITION  Human mutated in multiple advanced cancers protein (MMAC1) mRNA,
            complete cds.
ACCESSION   U92436
VERSION     U92436.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Steck,P.A., Pershouse,M.A., Jasser,S.A., Lin,H., Yung,W.K.A.,
            Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T.,
            Frye,C., Hu,R., Swedlund,B., Teng,D.H.F. and Tavtigian,S.V.
  TITLE     Identification of a candidate tumour suppressor gene, MMAC1, at
            chromosome 10q23.3 that is mutated in multiple advanced cancers
  JOURNAL   Nat. Genet. 15 (4), 356-362 (1997)
   PUBMED   9090379
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Steck,P.A., Pershouse,M.A., Jasser,S.A., Lin,H., Yung,W.K.A.,
            Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T.,
            Frye,C., Hu,R., Swedlund,B., Teng,D.H.F. and Tavtigian,S.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAR-1997) Research, Myriad Genetics Inc., 190 Wakara
            Way, Salt Lake City, UT 84108, USA
  REMARK    Collaboration between the Departments of Neuro-Oncology and
            Pathology at the Brain Tumor Center University of Texas M.D.
            Anderson Cancer Center and Myriad Genetics Inc.
FEATURES             Location/Qualifiers
     source          1..3160
                     /db_xref="H-InvDB:HIT000222622"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.3"
     gene            1..3160
                     /gene="MMAC1"
                     /note="mutated in multiple advanced cancers"
     CDS             1035..2246
                     /gene="MMAC1"
                     /codon_start=1
                     /product="MMAC1"
                     /protein_id="AAC51182.1"
                     /db_xref="GI:1916328"
                     /translation="MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEG
                     VYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK
                     PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT
                     RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC
                     QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVN
                     TFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN
                     RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
                     DEDQHTQITKV"
BASE COUNT          853 a          742 c          788 g          777 t
ORIGIN      
        1 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc
       61 ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt
      121 gatgtggcag gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact
      181 gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc
      241 tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga
      301 gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct
      361 gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct
      421 cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg
      481 aggcgcggcg gcggcggcgg cggcacctcc cgctcctgga gcggggggga gaagcggcgg
      541 cggcggcggc cgcggcggct gcagctccag ggagggggtc tgagtcgcct gtcaccattt
      601 ccagggctgg gaacgccgga gagttggtct ctccccttct actgcctcca acacggcggc
      661 ggcggcggcg gcacatccag ggacccgggc cggttttaaa cctcccgtcc gccgccgccg
      721 caccccccgt ggcccgggct ccggaggccg ccggcggagg cagccgttcg gaggattatt
      781 cgtcttctcc ccattccgct gccgccgctg ccaggcctct ggctgctgag gagaagcagg
      841 cccagtcgct gcaaccatcc agcagccgcc gcagcagcca ttacccggct gcggtccaga
      901 gccaagcggc ggcagagcga ggggcatcag ctaccgccaa gtccagagcc atttccatcc
      961 tgcagaagaa gccccgccac cagcagcttc tgccatctct ctcctccttt ttcttcagcc
     1021 acaggctccc agacatgaca gccatcatca aagagatcgt tagcagaaac aaaaggagat
     1081 atcaagagga tggattcgac ttagacttga cctatattta tccaaacatt attgctatgg
     1141 gatttcctgc agaaagactt gaaggcgtat acaggaacaa tattgatgat gtagtaaggt
     1201 ttttggattc aaagcataaa aaccattaca agatatacaa tctttgtgct gaaagacatt
     1261 atgacaccgc caaatttaat tgcagagttg cacaatatcc ttttgaagac cataacccac
     1321 cacagctaga acttatcaaa cccttttgtg aagatcttga ccaatggcta agtgaagatg
     1381 acaatcatgt tgcagcaatt cactgtaaag ctggaaaggg acgaactggt gtaatgatat
     1441 gtgcatattt attacatcgg ggcaaatttt taaaggcaca agaggcccta gatttctatg
     1501 gggaagtaag gaccagagac aaaaagggag taactattcc cagtcagagg cgctatgtgt
     1561 attattatag ctacctgtta aagaatcatc tggattatag accagtggca ctgttgtttc
     1621 acaagatgat gtttgaaact attccaatgt tcagtggcgg aacttgcaat cctcagtttg
     1681 tggtctgcca gctaaaggtg aagatatatt cctccaattc aggacccaca cgacgggaag
     1741 acaagttcat gtactttgag ttccctcagc cgttacctgt gtgtggtgat atcaaagtag
     1801 agttcttcca caaacagaac aagatgctaa aaaaggacaa aatgtttcac ttttgggtaa
     1861 atacattctt cataccagga ccagaggaaa cctcagaaaa agtagaaaat ggaagtctat
     1921 gtgatcaaga aatcgatagc atttgcagta tagagcgtgc agataatgac aaggaatatc
     1981 tagtacttac tttaacaaaa aatgatcttg acaaagcaaa taaagacaaa gccaaccgat
     2041 acttttctcc aaattttaag gtgaagctgt acttcacaaa aacagtagag gagccgtcaa
     2101 atccagaggc tagcagttca acttctgtaa caccagatgt tagtgacaat gaacctgatc
     2161 attatagata ttctgacacc actgactctg atccagagaa tgaacctttt gatgaagatc
     2221 agcatacaca aattacaaaa gtctgaattt ttttttatca agagggataa aacaccatga
     2281 aaataaactt gaataaactg aaaatggacc tttttttttt taatggcaat aggacattgt
     2341 gtcagattac cagttatagg aacaattctc ttttcctgac caatcttgtt ttaccctata
     2401 catccacagg gttttgacac ttgttgtcca gttgaaaaaa ggttgtgtag ctgtgtcatg
     2461 tatatacctt tttgtgtcaa aaggacattt aaaattcaat taggattaat aaagatggca
     2521 ctttcccgtt ttattccagt tttataaaaa gtggagacag actgatgtgt atacgtagga
     2581 attttttcct tttgtgttct gtcaccaact gaagtggcta aagagctttg tgatatactg
     2641 gttcacatcc tacccctttg cacttgtggc aacagataag tttgcagttg gctaagagag
     2701 gtttccgaaa ggttttgcta ccattctaat gcatgtattc gggttagggc aatggagggg
     2761 aatgctcaga aaggaaataa ttttatgctg gactctggac catataccat ctccagctat
     2821 ttacacacac ctttctttag catgctacag ttattaatct ggacattcga ggaattggcc
     2881 gctgtcactg cttgttgttt gcgcattttt ttttaaagca tattggtgct agaaaaggca
     2941 gctaaaggaa gtgaatctgt attggggtac aggaatgaac cttctgcaac atcttaagat
     3001 ccacaaatga agggatataa aaataatgtc ataggtaaga aacacagcaa caatgactta
     3061 accatataaa tgtggaggct atcaacaaag aatgggcttg aaacattata aaaattgaca
     3121 atgatttatt aaatatgttt tctcaattgt aaaaaaaaaa
//