LOCUS HSU49260 1812 bp mRNA linear HUM 17-APR-1996
DEFINITION Human mevalonate pyrophosphate decarboxylase (MPD) mRNA, complete
cds.
ACCESSION U49260
VERSION U49260.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1812)
AUTHORS Toth,M.J. and Huwyler,L.
TITLE Molecular cloning and expression of the cDNAs encoding human and
yeast mevalonate pyrophosphate decarboxylase
JOURNAL J. Biol. Chem. 271 (14), 7895-7898 (1996)
PUBMED 8626466
REFERENCE 2 (bases 1 to 1812)
AUTHORS Toth,M.J.
TITLE Direct Submission
JOURNAL Submitted (15-FEB-1996) Matthew J. Toth, Research-CV, Ciba-Geigy,
556 Morris Ave, Summit, NJ 07901, USA
FEATURES Location/Qualifiers
source 1..1812
/db_xref="H-InvDB:HIT000220088"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
gene 1..1812
/gene="MPD"
CDS 8..1210
/gene="MPD"
/EC_number="4.1.1.33"
/function="cholesterol biosynthesis pathway enzyme"
/codon_start=1
/product="mevalonate pyrophosphate decarboxylase"
/protein_id="AAC50440.1"
/translation="MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLH
QDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPL
PSSLSCKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSAC
RSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRAS
VETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISY
LNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGS
NGDTFLKGLQVRPAPLSAELQAALAMEPTPGGVKYIIVTQVGPGPQILDDPCAHLLGP
DGLPKPAA"
BASE COUNT 327 a 563 c 610 g 312 t
ORIGIN
1 tgggaccatg gcctcggaga agccgctggc ggcagtcact tgtacagcgc cggtcaacat
61 cgcggtcatc aagtactggg gcaagcgcga tgaagagctg gttctgccca tcaactcctc
121 cctgagcgtc actctgcacc aggaccagtt aaaaaccacc acaacagccg tcatcagcaa
181 ggacttcacc gaggaccgga tttggctgaa tggccgggag gaggatgtgg ggcagccgag
241 gctgcaggcc tgcctgcggg agatccgctg cctggcccgg aagcggagga actcacggga
301 tggggacccg ctgccctcca gcctcagctg caaggtgcac gtggcatcgg tgaacaactt
361 ccccacggct gcgggcctgg cctcctcagc ggcgggctat gcctgcctag cctacaccct
421 ggcccgtgtc tacggcgtgg agagtgacct ctcagaagtg gctcgccggg gctcaggcag
481 cgcctgccgg agcctgtatg ggggctttgt ggagtggcag atgggagagc aggccgacgg
541 gaaggacagc atcgctcggc aagtggcccc cgagtcacac tggcctgaac tccgcgtgct
601 catccttgtg gtgagcgctg agaagaagct gacaggcagt accgtgggca tgcgggccag
661 tgtggagacc agccccctgc ttcggttccg ggccgagtcc gtggtgcccg cgcgcatggc
721 ggagatggcc cgctgcatcc gggagcgaga cttccccagc ttcgcccagc tgaccatgaa
781 ggacagcaac cagttccacg ccacctgcct cgacaccttc ccgcccatct cttacctcaa
841 tgccatctcc tggcgcatca tccacctggt gcaccgcttc aacgcccacc acggggacac
901 caaggtggcg tacacctttg acgcgggccc caatgccgtg atcttcaccc tggacgacac
961 tgtggctgag tttgtggctg ctgtgtggca cggctttccc ccaggctcga atggagacac
1021 gtttctgaag gggctgcagg tgaggccggc ccctctctca gctgagcttc aggctgcgct
1081 ggccatggag ccgacccccg gtggggtcaa atacatcatt gtcactcagg tggggccagg
1141 gcctcaaatc ctggatgacc cctgcgccca cctcctgggt cctgacggcc tgccgaagcc
1201 agctgcctga ctgcctcagc agggaccgca tgccgcttgg agaaggggtg gcctcgccgg
1261 agctagggag cggatgtggt gggctggccg gactcctggg acatgtgggt ggtggcttga
1321 ccccgggccc atgggcagct tgctgtgggg cagtgcaggg agtcctgcgg ccgcccaggt
1381 gtcaggagag gtccccgccg agtgcttcag ctgccctaag ctgcaccagc gctttgccaa
1441 gatgggatgg ggagggggta tgagaactgg cagagcctcg gtgcagcagg gctgaagggc
1501 tttctcaccc cagctctggc tatgcccagt tctctgagaa aggagctcag tggggaggtg
1561 gtccctccag cggaccaggg aaggggtcac tgtgctggga gcagcctcct tgggcctcag
1621 gaaaccacca agtgcctcgg atggtggctg cccacggcgc ttctgctgag accctgcccc
1681 cggcccaggt gtctcggagg gtggctgccc acggcctggg tgtggctgga atggtggcag
1741 gagtgggcac cagtgcggcc ccggtggcca tggggaataa accagcattg ctgccaaaaa
1801 aaaaaaaaaa aa
//