LOCUS HSU47742 7869 bp mRNA linear HUM 31-AUG-1996
DEFINITION Human monocytic leukaemia zinc finger protein (MOZ) mRNA, complete
cds.
ACCESSION U47742
VERSION U47742.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7869)
AUTHORS Borrow,J., Stanton,V.P., Andresen,J.M., Becher,R., Behm,F.G.,
Chaganti,R.S.K., Civin,C.I., Disteche,C., Dube,I., Frischauf,A.M.,
Horsman,D., Mitelman,F., Volinia,S., Watmore,A.E. and Housman,D.E.
TITLE The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses
a putative acetyltransferase to the CREB-binding protein
JOURNAL Nat. Genet. 14 (1), 33-41 (1996)
PUBMED 8782817
REFERENCE 2 (bases 1 to 7869)
AUTHORS Borrow,J., Stanton,V.P., Andresen,J.M., Becher,R., Behm,F.G.,
Chaganti,R.S.K., Civin,C.I., Disteche,C., Dube,I., Frischauf,A.M.,
Horsman,D., Mitelman,F., Volinia,S., Watmore,A.E. and Housman,D.E.
TITLE Direct Submission
JOURNAL Submitted (30-JAN-1996) Julian Borrow, Center for Cancer Research,
E17-540, Massachusetts Institute of Technology, 77 Massachusetts
Avenue, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..7869
/db_xref="H-InvDB:HIT000220036"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11"
/cell_line="U937"
gene 1..7869
/gene="MOZ"
CDS 394..6408
/gene="MOZ"
/codon_start=1
/product="monocytic leukaemia zinc finger protein"
/protein_id="AAC50662.1"
/translation="MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDR
KTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKL
IKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRL
LKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQ
NREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNAD
NMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNP
IGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDF
CRDSNVSLRFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRC
PSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPP
ANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVK
GCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKP
LSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFR
SDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGE
NEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSL
PANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYT
ESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRR
YSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHN
SSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRL
SSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPL
KKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKI
QESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE
TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQP
SHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEES
SEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSV
RSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSD
LGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMA
SMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQP
APQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGST
GNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSV
SLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHT
QRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMG
VNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMM
GSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR"
misc_feature 1018..1323
/gene="MOZ"
/note="encodes C4HC3 zinc finger domains; known as LAP,
PHD and TTC domains"
misc_feature 1957..2502
/gene="MOZ"
/note="encodes MYST domain; homologous to C2HC zinc finger
acetyltransferase"
misc_feature 2755..4827
/gene="MOZ"
/note="encodes acidic domain"
misc_feature 5033..5034
/gene="MOZ"
/note="breakpoint position in MOZ-CBP t(8;16) AML fusion
message"
misc_feature 5332..5496
/gene="MOZ"
/note="encodes proline/glutamine domain"
misc_feature 5512..6405
/gene="MOZ"
/note="encodes methionine-rich domain"
BASE COUNT 2323 a 1833 c 1857 g 1856 t
ORIGIN
1 ggcacgaggt ttggggcatc tccgcggtcc ggcccggggc cccgggatct cggctgtcct
61 tcctcccggc ataagatgca catttttctg ctctggagcc gggaatgaaa tattcttgag
121 ttcttacaac tttatgacga gacccatgtg tggtgctatt gagaaattca ttgggaagtt
181 ggaagacatt tcaaacaaca ggttgttttg gtttctatag tacaattggg gtggcattct
241 gttttgtgaa aggaggaagg acttaggcca gaaaactcat atgctatggt taactggttc
301 ccagcctccg agaatcttgt tttccatggt gtaaaactta ctcagcatca ggataaggga
361 taacgactct atggatatac agaatccttc accatggtaa aactcgcaaa cccgctttat
421 actgagtgga ttttggaggc catcaaaaaa gtgaaaaagc agaaacagcg tccttcagaa
481 gaaaggatat gcaatgctgt gtcttcatcc catggcttgg atcgtaaaac tgttttagaa
541 caattggagt tgagtgttaa agatggaaca attttaaaag tctcaaataa aggactcaat
601 tcctataaag atcctgataa tcctgggcga atagcacttc ctaagcctcg gaaccatgga
661 aaattggata ataaacaaaa tgtggattgg aataaactga taaagcgggc agttgagggc
721 ttggcagagt ctggtggctc aactttgaaa agcattgaac gttttttgaa aggtcagaag
781 gatgtgtctg cattattcgg aggcagtgct gcctctggct ttcaccagca gttacgattg
841 gctatcaaac gtgccattgg ccacggcaga ctccttaaag atggacctct ttatcggctc
901 aacactaaag caaccaacgt ggatgggaaa gagagttgtg agtctctttc ctgtttacct
961 ccagtgtccc ttcttccaca tgaaaaggat aagccggttg ctgaaccaat ccccatctgt
1021 agtttctgtc ttggtacaaa agaacaaaac cgagaaaaga agccagagga actcatctcc
1081 tgtgccgact gtggcaacag tggccatcca tcctgtttaa agttttcccc tgaactaacg
1141 gttcgagtga aggccttacg gtggcagtgc atcgagtgta aaacatgcag ctcctgtcga
1201 gatcaaggca aaaatgcgga taacatgctc ttttgtgatt catgtgaccg aggttttcac
1261 atggagtgtt gtgatccgcc actcacccgt atgccaaaag gcatgtggat atgtcaaata
1321 tgtcgaccta ggaaaaaagg acgaaaactt ctacaaaaga aggcagcaca gataaaacgg
1381 cgctatacta atccaatagg acgtccaaaa aacaggttaa agaaacaaaa cacggtatca
1441 aaaggtccct tcagcaaagt tcgaactggc cctggaaggg gtaggaaacg aaaaatcact
1501 ctttccagcc aatcagcatc atcatcatca gaagaaggat atttagagcg gatagatggc
1561 ttggacttct gcagagatag caatgtctcc ttgaggttca acaagaaaac caaagggctc
1621 attgatggcc ttaccaaatt ttttacccct tcccctgatg ggcggaaagc tcggggggaa
1681 gtggtggact actctgagca atatcgaatc agaaagaggg gcaacaggaa atcaagcact
1741 tcagattggc ccacagacaa tcaggatggc tgggatggca aacaagaaaa tgaggagcga
1801 ctttttggga gccaggaaat catgactgag aaagatatgg aattatttcg tgatatccaa
1861 gaacaagcac tgcagaaagt tggagtgact ggtccccctg atccacaagt ccgctgtccc
1921 tctgtcattg agtttgggaa gtatgaaatt cacacctggt actcctcccc atatcctcaa
1981 gaatactcaa ggctgcccaa attgtatctt tgtgaatttt gtctaaaata tatgaaaagt
2041 agaactattc tgcagcagca catgaagaaa tgtggttggt tccatcctcc tgccaatgag
2101 atttacagaa agaataatat ttctgtcttt gaggttgatg ggaatgtgag taccatttat
2161 tgtcaaaacc tgtgtctttt ggcaaagttg tttcttgacc acaaaaccct ctattacgat
2221 gtggagccat ttctttttta tgtactaaca cagaatgatg tcaagggctg ccaccttgtt
2281 ggctactttt ctaaggaaaa gcactgccaa cagaagtaca atgtttcctg tataatgatt
2341 cttcctcaat accagcgtaa gggctatggc aggtttctca tcgatttcag ttatttgtta
2401 tcaaagcgtg aaggccaagc agggtctcca gagaaaccgt tatctgatct gggtcgtctt
2461 tcctacatgg catattggaa aagtgtaata ttggagtgcc tttatcacca aaatgacaag
2521 cagatcagca ttaagaagtt aagcaagttg actggaatct gccctcaaga catcacttcc
2581 acactccacc acctacgaat gctggacttc cgtagtgacc aatttgtgat tatccgccgg
2641 gaaaaactta tccaggatca catggcaaag cttcagctga atttgcgacc tgtagatgta
2701 gatccagaat gtttgcgctg gactccagtc atagtgtcca actctgtggt ctcagaggag
2761 gaagaagagg aggctgagga aggagaaaac gaagagccac agtgccagga aagagaatta
2821 gagatcagtg tgggaaagtc tgtgtctcat gagaacaaag aacaagattc ttattcagta
2881 gaaagtgaaa agaaaccaga agttatggct ccagtcagtt ctacacgttt gagcaaacaa
2941 gtccttcctc atgatagtct tcctgcaaat agccagccat ctcggagggg ccgctggggg
3001 aggaagaaca gaaaaaccca ggaacgtttt ggtgataaag attctaaact gctcttggaa
3061 gagacgtctt cagctcctca ggaacaatat ggagaatgtg gggagaaatc agaagccacc
3121 caggaacaat acactgaaag tgaagaacag ctggtggctt ctgaggagca gccaagccag
3181 gacgggaaac ctgaccttcc caagagaaga ctcagtgagg gggttgagcc ctggcgagga
3241 cagctcaaga aaagccctga ggctctgaag tgcagattaa cagaaggaag tgagaggctg
3301 ccccgtcgct acagtgaggg tgacagggct gtcctcaggg gcttcagtga gagcagcgag
3361 gaggaggagg agccggaaag ccctcggtca agctcgccac caattctcac aaagcccacg
3421 ctgaagcgaa agaaaccatt tctccaccga aggaggagag tccgaaagcg caaacaccac
3481 aatagcagtg tagtcacaga aactatttct gagaccactg aagtgttaga tgaacctttt
3541 gaagattctg actccgagag gccaatgcca agattagaac ccacatttga gatcgatgaa
3601 gaagaggagg aagaggatga aaatgaactt ttccctagag aatacttccg tcgtttgtct
3661 tcgcaggatg tactcaggtg tcagtcctct tctaagagga agtctaaaga tgaagaagaa
3721 gatgaagagt cagatgatgc tgatgacact cctatcttaa agccagtatc tcttttgcga
3781 aaacgtgatg tgaagaattc tcctcttgag ccagatacat ccacaccttt gaaaaagaaa
3841 aagggatggc ccaaaggcaa gagccgcaaa ccaatccact ggaagaaaag acctggtcga
3901 aaaccaggat ttaagttgag tcgggaaatc atgccagttt ctactcaagc atgcgtcatt
3961 gagcccatcg tttccattcc taaagctgga cgtaaaccca agatccagga gagtgaagaa
4021 actgttgagc caaaagaaga catgccccta cccgaggaga ggaaggagga ggaggagatg
4081 caagcagagg cagaagaggc tgaagagggt gaggaagagg atgcagccag cagtgaagtc
4141 ccagcagcct ctccagcaga cagcagcaat agtcctgaga ccgaaaccaa ggagcctgag
4201 gtggaggagg aagaagagaa gccccgtgtc tcagaggagc agaggcagtc agaggaggag
4261 cagcaggaat tagaggagcc agagccagag gaggaggaag atgcagctgc agagactgcc
4321 cagaatgacg accacgacgc tgatgatgag gatgatggcc acctggagtc cacaaagaaa
4381 aaggagctag aggaacagcc cacgagggaa gatgtcaagg aggagcctgg tgttcaagag
4441 tcttttttag atgctaatat gcagaagagt agggaaaaga taaaggataa agaggaaacc
4501 gagctggatt ccgaagagga gcagccttcc catgacacgt ccgtggtgtc agagcagatg
4561 gctgggtctg aggacgacca cgaagaagac tcccacacta aggaagagtt aatcgaatta
4621 aaagaggagg aagagattcc tcatagtgag ctggatctgg aaactgtaca ggcagtgcag
4681 tctttgactc aagaagaaag cagtgagcat gagggcgcct accaggactg tgaggaaact
4741 cttgcggcgt gtcagaccct gcagagttac acccaggctg acgaggaccc tcagatgtcc
4801 atggttgaag actgtcatgc gtcagaacat aatagcccta tctcctccgt tcagtctcac
4861 cccagccagt cagtccgttc ggtcagcagt cccaacgtgc ctgcccttga gagtggctac
4921 acccagatca gcccagaaca aggatccctg tccgcaccct ctatgcagaa catggagacc
4981 agccccatga tggatgtgcc ttccgtatca gaccactctc agcaggtggt ggacagcggc
5041 ttcagtgacc tgggcagcat tgagagcacc actgaaaact atgagaaccc aagcagttac
5101 gactccacga tgggcggcag catctgtggg aacagctctt cccagagcag ctgctcctac
5161 ggtgggctgt cgtcctccag cagcctcacc cagagcagct gtgtggtcac tcagcagatg
5221 gccagcatgg gcagcagctg cagcatgatg cagcagagca gcgtccagcc tgctgccaac
5281 tgcagcatca agtcacctca gagctgcgtg gtggagaggc ctcccagtaa ccagcagcag
5341 cagccgccac caccgcctcc acagcagcca cagccgccgc cgccacaacc acaaccagca
5401 ccacagcctc caccacccca gcagcagccg caacagcagc cgcagcctca gccccagcag
5461 cctccacccc caccccctcc ccagcagcag cccccgctgt cacagtgtag tatgaataac
5521 agtttcaccc cagctcctat gatcatggag ataccagaat ctggaagcac tgggaacata
5581 agtatctatg agaggattcc aggggatttt ggtgccggca gctactctca accatcagcc
5641 accttcagcc tagccaagct gcagcagctg accaacacca ttatggaccc tcatgccatg
5701 ccttatagcc attctcctgc tgtgacttcc tatgcaacca gtgtttctct gtccaataca
5761 ggactggctc agctggctcc atctcatccc ttagctggga ctcctcaagc acaagccacc
5821 atgacgccac ccccaaactt ggcatccact accatgaacc tcacatctcc tctgcttcag
5881 tgcaacatgt ctgccaccaa cattggcatt cctcacacgc agagattgca agggcaaatg
5941 ccagtgaagg ggcacatttc catccgctcc aagtctgcgc cactgccctc tgcggctgct
6001 caccagcagc agctgtatgg ccgtagccca tcggcagttg ccatgcaggc tggccctcgc
6061 gcactggctg ttcagcgtgg catgaacatg ggggttaatc tgatgcctac tcccgcctat
6121 aatgtcaatt ccatgaatat gaacaccttg aatgccatga acagctatcg aatgacacag
6181 cccatgatga acagcagtta ccatagtaac cctgcctaca tgaaccagac agcacagtat
6241 cctatgcaga tgcagatggg aatgatgggg agccaggcct atacccagca gcctatgcag
6301 cctaaccctc atgggaacat gatgtacaca ggcccctccc atcacagcta catgaacgct
6361 gctggcgtgc ccaagcagtc actcaacgga ccttacatga gaagatgagc aagatgaact
6421 tgcaatcaaa aacttaaata tatataaata aaggaacctt ttatactgac aaaccagaga
6481 aaaatggacc tttttccagt taaaatattg ctgtagattt agaggaattt ttctttggtt
6541 tattttattt tttagaaaac ctgatcttct cttttttttg ggttcatttt gttgtgggtt
6601 ttggttttct tcacaatctt gaacatttta cagtagaact catctaaaaa tggatttggg
6661 gatggggaaa catgcacaaa atcttttcat aattaaaaag agccttactt tctttacata
6721 ccacatggac agaatttgtg taaaagtgaa ttatctttat tttaaaatgt atgtttcccc
6781 tcactgtttg cagctcccaa tgttgtcatt tttaaatgtt atatacatct caagggttaa
6841 ccagaccctt tcctccaaac ccaacctttc atttcctact tcattccagc aggaggcact
6901 taggggagac tcggatgggg acatggagaa caacccaagc tccttaaact tattattatt
6961 gttaatatta ttattattat tattaataaa gtgaggcagg aaaatgcttc tccttttaaa
7021 atcccctcca ctcctcacac acacacacct cttgaaaccc ttccccaaga atgtttcttt
7081 atagacggac ttcattgaaa tctttgttgt tcttgaatca agtgtaatat aatttttttc
7141 ttctttttta aaatattccc actcagcact cagagacaca aaaatactgt aagtctcaat
7201 taacagcaga atctcagaga aaagctgttt gcaatccaaa tccagccttt ggaggaatag
7261 agatggtcaa ttaacaatca aaaagaggag attaacctct tgttttttta ccacctggtg
7321 aatcagccat aacgcacaca cacgccaccc agcctcttgt ttctagtatg tactttgaaa
7381 tgctaactga gggtcttgat gcttgagcct ttgactgata aaactcaaat agcagtcccc
7441 agtgatttgc ctcttaggtt ctttcttaaa ttgttggtgg atgactgtac attttagtga
7501 tttgaaaaat aactgacaaa ccattgaaac agtttatttt atgttggaag agatggcgca
7561 gatgtgtgtc agaagggaga tcacggtgtg agtttcgtag ctatttaagt gatacatacc
7621 tctagttttt gtatgtcttt tgagatcctg agttcatccc ctgtgaatca gagtgcacaa
7681 gcacctctcc tgtgagtggc taatgagaag agggacagac cgaccaccag cacagtaggg
7741 cagatctgga cagcagaatg ttataacgca agttcatgtg ttgctcccaa ctccattctc
7801 ttttctctcg tgcaaccagt ttgcccattc tcttcctatt acttgctcca gggataggta
7861 aaaaaaaaa
//