LOCUS HSU26592 1964 bp mRNA linear HUM 18-NOV-1996
DEFINITION Human clone IS4 diabetes mellitus type I autoantigen (ICAp69) mRNA,
complete cds.
ACCESSION U26592
VERSION U26592.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1964)
AUTHORS Pietropaolo,M., Castano,L., Babu,S., Buelow,R., Kuo,Y.-L.S.,
Martin,S., Martin,A., Powers,A.C., Prochazka,M., Naggert,J.,
Leiter,E.H. and Eisenbarth,G.S.
TITLE Islet cell autoantigen 69 kD (ICA69). Molecular cloning and
characterization of a novel diabetes-associated autoantigen
JOURNAL J. Clin. Invest. 92 (1), 359-371 (1993)
PUBMED 8326004
REFERENCE 2 (bases 1 to 1964)
AUTHORS Gaedigk,R., Duncan,A.M., Miyazaki,I., Robinson,B.H. and Dosch,H.M.
TITLE ICA1 encoding p69, a protein linked to the development of type 1
diabetes, maps to human chromosome 7p22
JOURNAL Cytogenet. Cell Genet. 66 (4), 274-276 (1994)
PUBMED 8162706
REFERENCE 3 (bases 1 to 1964)
AUTHORS Miyazaki,I., Gaedigk,R., Hui,M.F., Cheung,R.K., Morkowski,J.,
Rajotte,R.V. and Dosch,H.M.
TITLE Cloning of human and rat p69 cDNA, a candidate autoimmune target in
type 1 diabetes
JOURNAL Biochim. Biophys. Acta 1227 (1-2), 101-104 (1994)
PUBMED 7918678
REFERENCE 4 (bases 1 to 1964)
AUTHORS Miyazaki,I., Cheung,R.K., Gaedigk,R., Hui,M.F., Van der Meulen,J.,
Rajotte,R.V. and Dosch,H.M.
TITLE T cell activation and anergy to islet cell antigen in type I
diabetes
JOURNAL J. Immunol. 154 (3), 1461-1469 (1995)
PUBMED 7822811
REFERENCE 5 (bases 1 to 1964)
AUTHORS Karges,W.J.P., Gaedigk,R., Hui,M.F., Cheung,R.K. and Dosch,H.M.
TITLE Direct Submission
JOURNAL Submitted (08-MAY-1995) Hans-Michael Dosch, Immunology and Cancer,
The Hospital for Sick Children, 555 University Ave., Toronto,
Ontario M5G 1X8, Canada
FEATURES Location/Qualifiers
source 1..1964
/db_xref="H-InvDB:HIT000218806"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p22"
/clone="IS4"
/cell_type="islet cell"
gene 1..1964
/gene="ICAp69"
CDS 125..388
/gene="ICAp69"
/codon_start=1
/product="diabetes mellitus type I autoantigen"
/protein_id="AAB19034.1"
/translation="MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKK
EDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICSF"
BASE COUNT 616 a 436 c 471 g 441 t
ORIGIN
1 gcgctccgac ctcggccggg aggctcctgg ggccggggct ccgaggttat aatataactt
61 atcctctcat gcttttttcc tgccccttct ccccaaatca tcaacaatag aagaagaaga
121 aaacatgtca ggacacaaat gcagttatcc ctgggactta caggatcgat atgctcaaga
181 taagtcagtt gtaaataaga tgcaacagaa atattgggag acgaagcagg cctttattaa
241 agccacaggg aagaaggaag atgaacatgt tgttgcctct gacgcggacc tggatgccaa
301 gctagagctg tttcattcaa ttcagagaac ctgtctggac ttatcgaaag caattgtact
361 ctatcaaaag aggatatgtt cattttagga ggccaaggca ggaggatcac ttggagccag
421 gagtttgaga ccagcctggg caacaaagtg agacccccat ctctacaaaa aataaaaaca
481 cttaaaaatt atccgggtac cgtgcatgtg cagtcccagc tactcaggag gctgaggcag
541 gaggatcaca gtgacctata atgagccgtt gtgctccagc ctgggcgaca gaagtcttgt
601 ctcaagaaga aaacgaactg ggaaaatttc ttcgatccca aggtttccaa gataaaacca
661 gagcaggaaa gatgatgcaa gcgacaggaa aggccctctg cttttcttcc cagcaaaggt
721 tggccttacg aaatcctttg tgtcgatttc accaagaagt ggagactttt cggcatcggg
781 ccatctcaga tacttggctg acggtgaacc gcatggaaca gtgcaggacg gaatatagag
841 gagcactatt atggatgaag gacgtgtctc aggagcttga tccagacctc tacaagcaaa
901 tggagaagtt caggaaggta caaacacaag tgcgccttgc aaaaaaaaac tttgacaaat
961 tgaagatgga tgtttgtcaa aaagtggatc ttcttggagc gagcagatgc aatctcttgt
1021 ctcacatgct agcaacatac cagaccactc tgcttcattt ttgggagaaa acttctcaca
1081 ctatggcagc catccatgag agtttcaaag gttatcaacc atatgaattt actactttaa
1141 agagcttaca agaccctatg aaaaaattag ttgagaaaga agagaagaag aaaatcaacc
1201 agcaggaaag tacagatgca gccgtgcagg agccgagcca attaatttca ttagaggaag
1261 aaaaccagcg caaggaatcc tctagtttta agactgaaga tggaaaaagt attttatctg
1321 ccttagacaa aggctctaca catactgcat gctcaggacc catagatgaa ctattagaca
1381 tgaaatctga ggaaggtgct tgcctgggac cagtggcagg gaccccggaa cctgaaggtg
1441 ctgacaaaga tgacctgctg ctgttgagtg agatcttcaa tgcttcctcc ttggaagagg
1501 gcgagttcag caaagagtgg gccgctgtgt ttggagacgg ccaagtgaag gagccagtgc
1561 ccactatggc cctgggagag ccagacccca aggcccagac aggctcaggt ttccttcctt
1621 cgcagctttt agaccaaaat atgaaagact tacaggcctc gctacaagaa cctgctaagg
1681 ctgcctcaga cctgactgcc tggttcagcc tcttcgctga cctcgaccca ctctcaaatc
1741 ctgatgctgt tgggaaaacc gataaagaac acgaattgct caatgcatga atctgtaccc
1801 ttcgggaggg cactcacatg ccgcccccag cagctcccct gggggctagc agaagtataa
1861 agtgatcagt atgctgtttt aataattatg tgccatttta ataaaatgaa agggtcaacg
1921 gccctgttta tattggtata aaaaaaaaaa aaaaaaaaaa aaaa
//