LOCUS HUMIGV3BA 2650 bp DNA linear HUM 30-NOV-1994
DEFINITION Human germline IgH chain (hv3005) V3-region.
ACCESSION M83134
VERSION M83134.1
KEYWORDS V-region; germline; immunoglobulin heavy chain.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2650)
AUTHORS Chen,P.P.
TITLE Structural analyses of human developmentally regulated Vh3 genes
JOURNAL Scand. J. Immunol. 31 (3), 257-267 (1990)
PUBMED 2320951
COMMENT Original source text: Homo sapiens (tissue library: Y79-EMBL-3)
DNA.
FEATURES Location/Qualifiers
source 1..2650
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="14q32.33"
/cell_line="Y79 retinoblastoma"
/tissue_lib="Y79-EMBL-3"
regulatory 1649..1656
/regulatory_class="other"
/gene="IGHV@"
/note="octamer recombination signal; G00-128-528"
CDS join(1782..1827,1929..2233)
/gene="IGHV@"
/codon_start=1
/product="immunoglobulin heavy chain V-region"
/protein_id="AAA56827.1"
/db_xref="GDB:G00-128-528"
/translation="MEFGLSWVFLVALLRGVQCQVQLVESGGGVVQPGRSLRLSCAAS
GFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQM
NSLRAEDTAVYYCAR"
sig_peptide join(1782..1827,1929..1939)
/gene="IGHV@"
/note="G00-128-528"
mat_peptide 1940..2233
/gene="IGHV@"
/product="immunoglobulin heavy chain V-region"
/note="G00-128-528"
gene join(1782..1827,1929..1939)
/gene="IGHV@"
exon 1929..2233
/gene="IGHV@"
/note="G00-128-528"
regulatory 2236..2242
/regulatory_class="other"
/gene="IGHV@"
/note="heptamer recombination signal; G00-128-528"
regulatory 2266..2274
/regulatory_class="other"
/gene="IGHV@"
/note="nonamer recombination signal; G00-128-528"
BASE COUNT 769 a 528 c 591 g 762 t
ORIGIN chromosome 14.
1 agatctttta tattccccat cgctttttgt ttcttctggg ctgtagcaga gatcattgat
61 tggcgctcag gaataagcag agttagtcta aaatgcaggc aaatacttaa acaactgagg
121 agattagaat ttaaagacaa gtgtatgata tgttttgaaa tataatgttt ctctttccag
181 ttttggtttt tgtcagcagc aaataatgat aagactgagc tgtttgcaaa ataaacttta
241 gtcttaaact tggcctgatt atttgcataa agtgcagcaa gaatattaat aataattctg
301 taggaaaagc ctgctagcac caggagtttc acagtctaat accatgagca cgtgcatcct
361 cacgcaactc actgaatatg tccaagccag cctattccaa tcttaaatgc catccagtgg
421 tatctgcccc aggtacacta atatatgggt cctgcttctc tctgcagctc ctctctcctc
481 agatttcagg ttttgtttat tgtttgtttt ctctctgata taaactcaga tatgttgaag
541 gttttctttt ttgtatttgt agtagttcag ctttgttgtt actgaggtca gaataagctc
601 atagtttaca catttttaca ttcccatgtc gagtagctgc ttttctctat caaatccatt
661 aactgagaga acaatcacat ttcgttacag gtgaacaatt aaatagtttg gcatatattt
721 atgtactgga atctaatgca gcttgaaatc aagtcatgcc tcactcattg aaaaaaacat
781 ggctaaattc tcaaagaact gtgctgagtg aaagaaacta aggaattaag agtaaatttt
841 acgtgataca tttgtagaaa ttttagaaga tgccactatt ataaattaac atggagaaga
901 tttaaatatt tctgagaata tgctattggg agtaatgggg atgtgagtta aatttcagag
961 gaataagaga aagatttagg gattaattta ttcaaacctt gattgaagtg ctgagtaaat
1021 ggttgcaaac ataggtctac gtttttcaaa tcattcacca taaatttgaa ttatttatta
1081 attacactcg aataaagcaa taacaaagaa actgatgaga taatatttga ctgaattgca
1141 gcaataaata gatcgatatt aacacaagga atataactga cttccaaaaa catacacatg
1201 aaccgtggtt cactctgcat atttagataa attacagaaa gtcgtcataa cagatgggga
1261 atcctgcaga cttcactagg catgggccat gctgccctgg agttgtctca ggggagctgc
1321 ctcctccagt ggttagagca caggcccaga taataggact gattgttttt agatgtgtta
1381 tcttagacac gctgcacaac tgctgtgttc tctatgtaaa ttatctcctg taaaatataa
1441 cattgaagcc tgcgttaaat atattgtgta aatatgtaag aataaaataa agttatgaga
1501 gctaagtgtt aatcaaggca caatcatata ataatatatt ttcctgaatg atggaattat
1561 taccaatctc ccccagggca cttcatctgc cctgagccca gcctctcctc agatgtccca
1621 ccccagagct tgctatatag tgggggacat gcaaataggg ccctccctct actgatgaaa
1681 accagcccag ccctgaccct gcagctctgg gagaggagcc cagcactgga agtcgccggt
1741 gtttccattc ggtgatcagc actgaacaca gaggactcac catggagttt gggctgagct
1801 gggttttcct cgttgctctt ttaagaggtg attcatggag aaatagagag actgagtgtg
1861 agtgaacatg agtgagaaaa actggatttg tgtggcattt tctgataacg gtgtccttct
1921 gtttgcaggt gtccagtgtc aggtgcagct ggtggagtct gggggaggcg tggtccagcc
1981 tgggaggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gctatgctat
2041 gcactgggtc cgccaggctc caggcaaggg gctagagtgg gtggcagtta tatcatatga
2101 tggaagtaat aaatactacg cagactccgt gaagggccga ttcaccatct ccagagacaa
2161 ttccaagaac acgctgtatc tgcaaatgaa cagcctgaga gctgaggaca cggctgtgta
2221 ttactgtgcg agagacacag tgaggggaag tcattgtgcg cccagacaca aacctccctg
2281 caggaacgct ggggggaaat cagcggcagg gggcgctcag gagccactga tcagagtcag
2341 ccctggaggc aggtgcagat ggaggctgtt tcctgtcagg atgtgggact ttgtcttctt
2401 ctgacagttc cccagggaac ctcttaaatt tagaaaactg tgcctaacaa tgtcttctct
2461 atgcatatga ggaccttttc tccctggcac aaaatgcaga ttgacgctga cacggatgaa
2521 aattcctcaa ccatggtcac aaggatcaga gtcctgagta acctcagggc ttcctggtga
2581 ttcttctcaa atcagaccca ggacagggac ctccgtgaga ttccctgact ggaacagtct
2641 ttatggatcc
//