LOCUS HUMTGFBIG 2691 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human transforming growth factor-beta induced gene product (BIGH3)
mRNA, complete cds.
ACCESSION M77349
VERSION M77349.1
KEYWORDS transforming growth factor-beta induced protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2691)
AUTHORS Skonier,J., Neubauer,M., Madisen,L., Bennett,K., Plowman,G.D. and
Purchio,A.F.
TITLE cDNA cloning and sequence analysis of beta ig-h3, a novel gene
induced in a human adenocarcinoma cell line after treatment with
transforming growth factor-beta
JOURNAL DNA Cell Biol. 11 (7), 511-522 (1992)
PUBMED 1388724
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2691
/db_xref="H-InvDB:HIT000196398"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="A549"
/cell_type="adenocarcinoma"
gene 1..2691
/gene="BIGH3"
CDS 48..2099
/gene="BIGH3"
/note="putative"
/codon_start=1
/product="transforming growth factor induced protein"
/protein_id="AAA61163.1"
/translation="MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQH
GPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALP
LSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLV
SNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLL
KADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYT
LLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTT
LEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAI
DLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLY
HGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDV
LKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELA
NILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGV
VHVITNVLQPPANRPQERGDELADSALEIFKQASAFSRASQRSVRLAPVYQKLLERMK
H"
sig_peptide 48..92
/gene="BIGH3"
/note="putative"
mat_peptide 93..2096
/gene="BIGH3"
/product="transforming growth factor-beta induced protein"
BASE COUNT 679 a 729 c 695 g 588 t
ORIGIN
1 gcttgcccgt cggtcgctag ctcgctcggt gcgcgtcgtc ccgctccatg gcgctcttcg
61 tgcggctgct ggctctcgcc ctggctctgg ccctgggccc cgccgcgacc ctggcgggtc
121 ccgccaagtc gccctaccag ctggtgctgc agcacagcag gctccggggc cgccagcacg
181 gccccaacgt gtgtgctgtg cagaaggtta ttggcactaa taggaagtac ttcaccaact
241 gcaagcagtg gtaccaaagg aaaatctgtg gcaaatcaac agtcatcagc tacgagtgct
301 gtcctggata tgaaaaggtc cctggggaga agggctgtcc agcagcccta ccactctcaa
361 acctttacga gaccctggga gtcgttggat ccaccaccac tcagctgtac acggaccgca
421 cggagaagct gaggcctgag atggaggggc ccggcagctt caccatcttc gcccctagca
481 acgaggcctg ggcctccttg ccagctgaag tgctggactc cctggtcagc aatgtcaaca
541 ttgagctgct caatgccctc cgctaccata tggtgggcag gcgagtcctg actgatgagc
601 tgaaacacgg catgaccctc acctctatgt accagaattc caacatccag atccaccact
661 atcctaatgg gattgtaact gtgaactgtg cccggctcct gaaagccgac caccatgcaa
721 ccaacggggt ggtgcacctc atcgataagg tcatctccac catcaccaac aacatccagc
781 agatcattga gatcgaggac acctttgaga cccttcgggc tgctgtggct gcatcagggc
841 tcaacacgat gcttgaaggt aacggccagt acacgctttt ggccccgacc aatgaggcct
901 tcgagaagat ccctagtgag actttgaacc gtatcctggg cgacccagaa gccctgagag
961 acctgctgaa caaccacatc ttgaagtcag ctatgtgtgc tgaagccatc gttgcggggc
1021 tgtctgtaga gaccctggag ggcacgacac tggaggtggg ctgcagcggg gacatgctca
1081 ctatcaacgg gaaggcgatc atctccaata aagacatcct agccaccaac ggggtgatcc
1141 actacattga tgagctactc atcccagact cagccaagac actatttgaa ttggctgcag
1201 agtctgatgt gtccacagcc attgaccttt tcagacaagc cggcctcggc aatcatctct
1261 ctggaagtga gcggttgacc ctcctggctc ccctgaattc tgtattcaaa gatggaaccc
1321 ctccaattga tgcccataca aggaatttgc ttcggaacca cataattaaa gaccagctgg
1381 cctctaagta tctgtaccat ggacagaccc tggaaactct gggcggcaaa aaactgagag
1441 tttttgttta tcgtaatagc ctctgcattg agaacagctg catcgcggcc cacgacaaga
1501 gggggaggta cgggaccctg ttcacgatgg accgggtgct gaccccccca atggggactg
1561 tcatggatgt cctgaaggga gacaatcgct ttagcatgct ggtagctgcc atccagtctg
1621 caggactgac ggagaccctc aaccgggaag gagtctacac agtctttgct cccacaaatg
1681 aagccttccg agccctgcca ccaagagaac ggagcagact cttgggagat gccaaggaac
1741 ttgccaacat cctgaaatac cacattggtg atgaaatcct ggttagcgga ggcatcgggg
1801 ccctggtgcg gctaaagtct ctccaaggtg acaagctgga agtcagcttg aaaaacaatg
1861 tggtgagtgt caacaaggag cctgttgccg agcctgacat catggccaca aatggcgtgg
1921 tccatgtcat caccaatgtt ctgcagcctc cagccaacag acctcaggaa agaggggatg
1981 aacttgcaga ctctgcgctt gagatcttca aacaagcatc agcgttttcc agggcttccc
2041 agaggtctgt gcgactagcc cctgtctatc aaaagttatt agagaggatg aagcattagc
2101 ttgaagcact acaggaggaa tgcaccacgg cagctctccg ccaatttctc tcagatttcc
2161 acagagactg tttgaatgtt ttcaaaacca agtatcacac tttaatgtac atgggccgca
2221 ccataatgag atgtgagcct tgtgcatgtg ggggaggagg gagagagatg tactttttaa
2281 atcatgttcc ccctaaacat ggctgttaac ccactgcatg cagaaacttg gatgtcactg
2341 cctgacattc acttccagag aggacctatc ccaaatgtgg aattgactgc ctatgccaag
2401 tccctggaaa aggagcttca gtattgtggg gctcataaaa catgaatcaa gcaatccagc
2461 ctcatgggaa gtcctggcac agtttttgta aagcccttgc acagctggag aaatggcatc
2521 attataagct atgagttgaa atgttctgtc aaatgtgtct cacatctaca cgtggcttgg
2581 aggcttttat ggggccctgt ccaggtagaa aagaaatggt atgtagagct tagatttccc
2641 tattgtgaca gagccatggt gtgtttgtaa taataaaacc aaagaaacat a
//