LOCUS HUMGDF1 2510 bp mRNA linear HUM 31-DEC-1994
DEFINITION Human growth/differentiation factor 1 (GDF-1) mRNA, complete cds.
ACCESSION M62302
VERSION M62302.1
KEYWORDS growth/differentiation factor 1; transforming growth factor-beta.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2510)
AUTHORS Lee,S.J.
TITLE Expression of growth/differentiation factor 1 in the nervous
system: conservation of a bicistronic structure
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (10), 4250-4254 (1991)
PUBMED 2034669
COMMENT Original source text: Homo sapiens (tissue library: Stratagene)
adult cerebellum and fetal brain (17-18 week abortus) cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2510
/db_xref="H-InvDB:HIT000196006"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="adult cerebellum and fetal brain (17-18 week
abortus)"
/tissue_lib="Stratagene"
gene 25..1077
/gene="UOG-1"
CDS 25..1077
/gene="UOG-1"
/note="ORF"
/codon_start=1
/protein_id="AAA58500.1"
/translation="MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGL
ARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPES
AWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYG
HSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEF
TKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVP
DIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPS
KAEKPLRNGLVKDKRF"
gene 1347..2465
/gene="GDF-1"
CDS 1347..2465
/gene="GDF-1"
/codon_start=1
/product="growth/differentiation factor 1"
/protein_id="AAA58501.1"
/translation="MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALG
LRDEPQGAPRLRPVPPVMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIV
RHIPDRGAPTRASEPVSAAGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPE
GGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALA
LRPRAPAACARLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSF
REVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADL
PCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR"
BASE COUNT 313 a 968 c 814 g 415 t
ORIGIN
1 ggacacggcg ggcgagcggg cggtatggcg gcggcggggc ccgcggcggg gccgacgggg
61 cccgagccca tgccgagcta cgcgcagcta gtgcagcgcg gctggggcag cgcgctggcg
121 gcggcgcggg gctgcacgga ctgcggctgg gggctggcgc gtcgcggcct ggctgagcac
181 gcgcacctgg cgccgcccga gctgctgctg ctggcgctcg gcgcgctggg ctggaccgcg
241 ctgcgctccg cggccactgc gcgcctcttt cggcccctgg cgaagcggtg ctgcctccag
301 cccagagatg ccgccaagat gcccgagagc gcttggaagt ttctcttcta cctgggcagc
361 tggagctaca gtgcctacct gctgtttggc accgactacc ccttcttcca tgacccacca
421 tctgtcttct acgactggac gccgggcatg gcagtgccac gggacattgc agccgcctac
481 ctgctccagg gaagcttcta tggccactcc atctacgcta cgctatacat ggacacctgg
541 cgcaaggact cggtggtcat gctgctccac cacgtggtca ctctcatcct catcgtctcc
601 tcctacgcct tccggtacca caatgtgggc atccttgtgc tcttcctgca cgatatcagt
661 gacgtgcagc ttgagttcac caagctcaac atttacttca agtcccgcgg cggctcctac
721 catcggctgc atgccttggc agcagacttg ggctgcctca gcttcggctt cagctggttc
781 tggttccgcc tctactggtt cccgctcaag gtcctgtatg ccaccagtca ctgcagtctg
841 cgcacggtgc ctgacatccc cttctacttc ttcttcaatg cgctcctgct gctgctcacc
901 cttatgaacc tctactggtt cctgtacatc gtggcgtttg cagccaaggt gttgacaggc
961 caggtgcacg agctgaagga cctgcgggag tatgacacag ccgaggccca gagcctgaag
1021 cccagcaaag ccgagaagcc actgaggaac ggcctggtga aggacaagcg cttctgaacc
1081 cctcggcccc gcccccgtgg acccggcccc accccgaata ccccggccac gctccccgtc
1141 cttggccgcc cctccacccc ctccaactct gctcctctag ggccgccgcc acctcccctg
1201 ggaccccgcc ccctcatcct gcctccattt cccggccacg ccccccagga cccctgcccc
1261 tccggggaca ccggccccgc cctcagccca ctggtcccgg gccgccgcgg accctgcgca
1321 ctctctggtc atcgcctggg aggaagatgc caccgccgca gcaaggtccc tgcggccacc
1381 acctcctcct cctcctggcc ctgctgctgc cctcgctgcc cctgacccgc gcccccgtgc
1441 ccccaggccc agccgccgcc ctgctccagg ctctaggact gcgcgatgag ccccagggtg
1501 cccccaggct ccggccggtt cccccggtca tgtggcgcct gtttcgacgc cgggaccccc
1561 aggagaccag gtctggctcg cggcggacgt ccccaggggt caccctgcaa ccgtgccacg
1621 tggaggagct gggggtcgcc ggaaacatcg tgcgccacat cccggaccgc ggtgcgccca
1681 cccgggcctc ggagcctgtc tcggccgcgg ggcattgccc tgagtggaca gtcgtcttcg
1741 acctgtcggc tgtggaaccc gctgagcgcc cgagccgggc ccgcctggag ctgcgtttcg
1801 cggcggcggc ggcggcagcc ccggagggcg gctgggagct gagcgtggcg caagcgggcc
1861 agggcgcggg cgcggacccc gggccggtgc tgctccgcca gttggtgccc gccctggggc
1921 cgccagtgcg cgcggagctg ctgggcgccg cttgggctcg caacgcctca tggccgcgca
1981 gcctccgcct ggcgctggcg ctacgccccc gggcccctgc cgcctgcgcg cgcctggccg
2041 aggcctcgct gctgctggtg accctcgacc cgcgcctgtg ccaccccctg gcccggccgc
2101 ggcgcgacgc cgaacccgtg ttgggcggcg gccccggggg cgcttgtcgc gcgcggcggc
2161 tgtacgtgag cttccgcgag gtgggctggc accgctgggt catcgcgccg cgcggcttcc
2221 tggccaacta ctgccagggt cagtgcgcgc tgcccgtcgc gctgtcgggg tccggggggc
2281 cgccggcgct caaccacgct gtgctgcgcg cgctcatgca cgcggccgcc ccgggagccg
2341 ccgacctgcc ctgctgcgtg cccgcgcgcc tgtcgcccat ctccgtgctc ttctttgaca
2401 acagcgacaa cgtggtgctg cggcagtatg aggacatggt ggtggacgag tgcggctgcc
2461 gctaacccgg ggcgggcagg gacgcgggcc caacaataaa tgccgcgtgg
//