LOCUS HUMATCT4A 1742 bp DNA linear HUM 24-JAN-1994 DEFINITION Human T4 surface glycoprotein CD4 gene, complete cds. ACCESSION M35160 VERSION M35160.1 KEYWORDS glycoprotein; immunoglobulin super gene family; recognition antigen; surface antigen. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1742) AUTHORS Hodge,T.W., Sasso,D.R. and McDougal,J.S. TITLE Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240 JOURNAL Hum. Immunol. 30 (2), 99-104 (1991) PUBMED 1708753 REFERENCE 2 (bases 1 to 1742) AUTHORS Hodge,T.W. TITLE Direct Submission JOURNAL Submitted (12-JUN-1990) T.W. Hodge, A-25 Bldg. 1, Rm. 1226, Centers for Disease Control, 1600 Clifton Rd. Atlanta, GA 30333 USA COMMENT A cytosine to thymidine transition at nucleotide position 868 results in substitution of TRP-240 for ARG-240. FEATURES Location/Qualifiers source 1..1742 /organism="Homo sapiens" /mol_type="unassigned DNA" /db_xref="taxon:9606" /haplotype="OKT4-negative" gene 76..1452 /gene="CD4" CDS 76..1452 /gene="CD4" /note="T4 surface glycoprotein precursor" /codon_start=1 /protein_id="AAA16069.1" /translation="MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTAS QKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIE DSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRG KNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQ VEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKWVTQDPKLQMGK KLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPT SPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWST PVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHR FQKTCSPI" sig_peptide 76..150 /gene="CD4" /note="T4 surface glycoprotein signal peptide" mat_peptide 151..1449 /gene="CD4" /product="T4 surface glycoprotein mature peptide" variation 792 /gene="CD4" /note="g in OKT4 epitope deficiency; c in wt" BASE COUNT 405 a 491 c 466 g 380 t ORIGIN 1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc 61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa 121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat 181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac 241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag 301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc 361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag 421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag 481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt 541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag 601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc 661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag 721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt 781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac 841 ctgaagaaca aggaagtgtc tgtaaaatgg gttacccagg accctaagct ccagatgggc 901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga 961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg 1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc 1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag 1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg 1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag 1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc 1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc 1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt 1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc 1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt 1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag 1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct 1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat 1741 cc //