LOCUS HUMHER3A 4975 bp mRNA linear HUM 11-JUN-1993 DEFINITION Human epidermal growth factor receptor (HER3) mRNA, complete cds. ACCESSION M34309 VERSION M34309.1 KEYWORDS HER3 gene; epidermal growth factor receptor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4975) AUTHORS Plowman,G.D., Whitney,G.S., Neubauer,M.G., Green,J.M., McDonald,V.L., Todaro,G.J. and Shoyab,M. TITLE Molecular cloning and expression of an additional epidermal growth factor receptor-related gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 4905-4909 (1990) PUBMED 2164210 COMMENT Original source text: Human cell line MDA-MB-361, cDNA to mRNA. Draft entry and computer-readable sequence for [1] kindly submitted by G.D.Plowman, 16-MAY-1990, for release after publication. FEATURES Location/Qualifiers source 1..4975 /db_xref="H-InvDB:HIT000195575" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 199..4227 /note="HER3 protein precursor" /codon_start=1 /protein_id="AAA35979.1" /translation="MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAEN QYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNL RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDT IDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHC FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNP HTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGT GSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVRE ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGG CWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMGGTATCN GSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGP ELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLE RGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVC IKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDH VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP PRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSA LSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGGSCQESAVSGSSERCPRPVSLHPMP RGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPL SPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRR RHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEY MNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD SAFDNPDYWHSRLFPKANAQRT" sig_peptide 199..255 /note="HER3 signal peptide" mat_peptide 256..4224 /product="HER3 protein" BASE COUNT 1195 a 1309 c 1327 g 1144 t ORIGIN Chromosome 12q13. 1 ctctcacaca cacacacccc tcccctgcca tccctccccg gactccggct ccggctccga 61 ttgcaatttg caacctccgc tgccgtcgcc gcagcagcca ccaattcgcc agcggttcag 121 gtggctcttg cctcgatgtc ctagcctagg ggcccccggg ccggacttgg ctgggctccc 181 ttcaccctct gcggagtcat gagggcgaac gacgctctgc aggtgctggg cttgcttttc 241 agcctggccc ggggctccga ggtgggcaac tctcaggcag tgtgtcctgg gactctgaat 301 ggcctgagtg tgaccggcga tgctgagaac caataccaga cactgtacaa gctctacgag 361 aggtgtgagg tggtgatggg gaaccttgag attgtgctca cgggacacaa tgccgacctc 421 tccttcctgc agtggattcg agaagtgaca ggctatgtcc tcgtggccat gaatgaattc 481 tctactctac cattgcccaa cctccgcgtg gtgcgaggga cccaggtcta cgatgggaag 541 tttgccatct tcgtcatgtt gaactataac accaactcca gccacgctct gcgccagctc 601 cgcttgactc agctcaccga gattctgtca gggggtgttt atattgagaa gaacgataag 661 ctttgtcaca tggacacaat tgactggagg gacatcgtga gggaccgaga tgctgagata 721 gtggtgaagg acaatggcag aagctgtccc ccctgtcatg aggtttgcaa ggggcgatgc 781 tggggtcctg gatcagaaga ctgccagaca ttgaccaaga ccatctgtgc tcctcagtgt 841 aatggtcact gctttgggcc caaccccaac cagtgctgcc atgatgagtg tgccgggggc 901 tgctcaggcc ctcaggacac agactgcttt gcctgccggc acttcaatga cagtggagcc 961 tgtgtacctc gctgtccaca gcctcttgtc tacaacaagc taactttcca gctggaaccc 1021 aatccccaca ccaagtatca gtatggagga gtttgtgtag ccagctgtcc ccataacttt 1081 gtggtggatc aaacatcctg tgtcagggcc tgtcctcctg acaagatgga agtagataaa 1141 aatgggctca agatgtgtga gccttgtggg ggactatgtc ccaaagcctg tgagggaaca 1201 ggctctggga gccgcttcca gactgtggac tcgagcaaca ttgatggatt tgtgaactgc 1261 accaagatcc tgggcaacct ggactttctg atcaccggcc tcaatggaga cccctggcac 1321 aagatccctg ccctggaccc agagaagctc aatgtcttcc ggacagtacg ggagatcaca 1381 ggttacctga acatccagtc ctggccgccc cacatgcaca acttcagtgt tttttccaat 1441 ttgacaacca ttggaggcag aagcctctac aaccggggct tctcattgtt gatcatgaag 1501 aacttgaatg tcacatctct gggcttccga tccctgaagg aaattagtgc tgggcgtatc 1561 tatataagtg ccaataggca gctctgctac caccactctt tgaactggac caaggtgctt 1621 cgggggccta cggaagagcg actagacatc aagcataatc ggccgcgcag agactgcgtg 1681 gcagagggca aagtgtgtga cccactgtgc tcctctgggg gatgctgggg cccaggccct 1741 ggtcagtgct tgtcctgtcg aaattatagc cgaggaggtg tctgtgtgac ccactgcaac 1801 tttctgaatg gggagcctcg agaatttgcc catgaggccg aatgcttctc ctgccacccg 1861 gaatgccaac ccatgggggg cactgccaca tgcaatggct cgggctctga tacttgtgct 1921 caatgtgccc attttcgaga tgggccccac tgtgtgagca gctgccccca tggagtccta 1981 ggtgccaagg gcccaatcta caagtaccca gatgttcaga atgaatgtcg gccctgccat 2041 gagaactgca cccaggggtg taaaggacca gagcttcaag actgtttagg acaaacactg 2101 gtgctgatcg gcaaaaccca tctgacaatg gctttgacag tgatagcagg attggtagtg 2161 attttcatga tgctgggcgg cacttttctc tactggcgtg ggcgccggat tcagaataaa 2221 agggctatga ggcgatactt ggaacggggt gagagcatag agcctctgga ccccagtgag 2281 aaggctaaca aagtcttggc cagaatcttc aaagagacag agctaaggaa gcttaaagtg 2341 cttggctcgg gtgtctttgg aactgtgcac aaaggagtgt ggatccctga gggtgaatca 2401 atcaagattc cagtctgcat taaagtcatt gaggacaaga gtggacggca gagttttcaa 2461 gctgtgacag atcatatgct ggccattggc agcctggacc atgcccacat tgtaaggctg 2521 ctgggactat gcccagggtc atctctgcag cttgtcactc aatatttgcc tctgggttct 2581 ctgctggatc atgtgagaca acaccggggg gcactggggc cacagctgct gctcaactgg 2641 ggagtacaaa ttgccaaggg aatgtactac cttgaggaac atggtatggt gcatagaaac 2701 ctggctgccc gaaacgtgct actcaagtca cccagtcagg ttcaggtggc agattttggt 2761 gtggctgacc tgctgcctcc tgatgataag cagctgctat acagtgaggc caagactcca 2821 attaagtgga tggcccttga gagtatccac tttgggaaat acacacacca gagtgatgtc 2881 tggagctatg gtgtgacagt ttgggagttg atgaccttcg gggcagagcc ctatgcaggg 2941 ctacgattgg ctgaagtacc agacctgcta gagaaggggg agcggttggc acagccccag 3001 atctgcacaa ttgatgtcta catggtgatg gtcaagtgtt ggatgattga tgagaacatt 3061 cgcccaacct ttaaagaact agccaatgag ttcaccagga tggcccgaga cccaccacgg 3121 tatctggtca taaagagaga gagtgggcct ggaatagccc ctgggccaga gccccatggt 3181 ctgacaaaca agaagctaga ggaagtagag ctggagccag aactagacct agacctagac 3241 ttggaagcag aggaggacaa cctggcaacc accacactgg gctccgccct cagcctacca 3301 gttggaacac ttaatcggcc acgtgggagc cagagccttt taagtccatc atctggatac 3361 atgcccatga accagggtaa tcttgggggg tcttgccagg agtctgcagt ttctgggagc 3421 agtgaacggt gcccccgtcc agtctctcta cacccaatgc cacggggatg cctggcatca 3481 gagtcatcag aggggcatgt aacaggctct gaggctgagc tccaggagaa agtgtcaatg 3541 tgtagaagcc ggagcaggag ccggagccca cggccacgcg gagatagcgc ctaccattcc 3601 cagcgccaca gtctgctgac tcctgttacc ccactctccc cacccgggtt agaggaagag 3661 gatgtcaacg gttatgtcat gccagataca cacctcaaag gtactccctc ctcccgggaa 3721 ggcacccttt cttcagtggg tctcagttct gtcctgggta ctgaagaaga agatgaagat 3781 gaggagtatg aatacatgaa ccggaggaga aggcacagtc cacctcatcc ccctaggcca 3841 agttcccttg aggagctggg ttatgagtac atggatgtgg ggtcagacct cagtgcctct 3901 ctgggcagca cacagagttg cccactccac cctgtaccca tcatgcccac tgcaggcaca 3961 actccagatg aagactatga atatatgaat cggcaacgag atggaggtgg tcctgggggt 4021 gattatgcag ccatgggggc ctgcccagca tctgagcaag ggtatgaaga gatgagagct 4081 tttcaggggc ctggacatca ggccccccat gtccattatg cccgcctaaa aactctacgt 4141 agcttagagg ctacagactc tgcctttgat aaccctgatt actggcatag caggcttttc 4201 cccaaggcta atgcccagag aacgtaactc ctgctccctg tggcactcag ggagcattta 4261 atggcagcta gtgcctttag agggtaccgt cttctcccta ttccctctct ctcccaggtc 4321 ccagcccctt ttccccagtc ccagacaatt ccattcaatc tttggaggct tttaaacatt 4381 ttgacacaaa attcttatgg tatgtagcca gctgtgcact ttcttctctt tcccaacccc 4441 aggaaaggtt ttccttattt tgtgtgcttt cccagtccca ttcctcagct tcttcacagg 4501 cactcctgga gatatgaagg attactctcc atatcccttc ctctcaggct cttgactact 4561 tggaactagg ctcttatgtg tgcctttgtt tcccatcaga ctgtcaagaa gaggaaaggg 4621 aggaaaccta gcagaggaaa gtgtaatttt ggtttatgac tcttaacccc ctagaaagac 4681 agaagcttaa aatctgtgaa gaaagaggtt aggagtagat attgattact atcataattc 4741 agcacttaac tatgagccag gcatcatact aaacttcacc tacattatct cacttagtcc 4801 tttatcatcc ttaaaacaat tctgtgacat acatattatc tcattttaca caaagggaag 4861 tcgggcatgg tggctcatgc ctgtaatctc agcactttgg gaggctgagg cagaaggatt 4921 acctgaggca aggagtttga gaccagctta gccaacatag taagaccccc atctc //