LOCUS HUMVINC 5102 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human vinculin mRNA, complete cds.
ACCESSION M33308
VERSION M33308.1
KEYWORDS cytoskeletal protein; vinculin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5102)
AUTHORS Weller,P.A., Ogryzko,E.P., Corben,E.B., Zhidkova,N.I., Patel,B.,
Price,G.J., Spurr,N.K., Koteliansky,V.E. and Critchley,D.R.
TITLE Complete sequence of human vinculin and assignment of the gene to
chromosome 10
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (15), 5667-5671 (1990)
PUBMED 2116004
COMMENT Original source text: Human endothelial cells, cDNA to mRNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by P.A.Weller, 28-MAR-1990.
FEATURES Location/Qualifiers
source 1..5102
/db_xref="H-InvDB:HIT000195504"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="10q22-q23"
gene 1..5102
/gene="VCL"
CDS 51..3251
/gene="VCL"
/note="vinculin"
/codon_start=1
/protein_id="AAA61283.1"
/db_xref="GDB:G00-125-348"
/translation="MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV
AAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSV
PARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTY
TKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNS
KNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSK
LNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ
VADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ
NWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRR
QGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPT
VDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGES
PQARALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREE
VFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARIL
LRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVA
MANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMV
MDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTD
ELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSS
KGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQC
TDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNL
MQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ"
BASE COUNT 1379 a 1248 c 1273 g 1202 t
ORIGIN Chromosome 10.
1 gaattccact tctctgtcgc ccgcggttcg ccgccccgct cgccgccgcg atgccagtgt
61 ttcatacgcg cacgatcgag agcatcctgg agccggtggc acagcagatc tcccacctgg
121 tgataatgca cgaggagggc gaggtggacg gcaaagccat tcctgacctc accgcgcccg
181 tggccgccgt gcaggcggcc gtcagcaacc tcgtccgggt tggaaaagag actgttcaaa
241 ccactgagga tcagattttg aagagagata tgccaccagc atttattaag gttgagaatg
301 cttgcaccaa gcttgtccag gcagctcaga tgcttcagtc agacccttac tcagtgcctg
361 ctcgagatta tctaattgat gggtcaaggg gcatcctctc tggaacatca gacctgctcc
421 ttaccttcga tgaggctgag gtccgtaaaa ttattagagt ttgcaaagga attttggaat
481 atcttacagt ggcagaggtg gtggagacta tggaagattt ggtcacttac acaaagaatc
541 ttgggccagg aatgactaag atggccaaga tgattgacga gagacagcag gagctcactc
601 accaggagca ccgagtgatg ttggtgaact cgatgaacac cgtgaaagag ttgctgccag
661 ttctcatttc agctatgaag atttttgtaa caactaaaaa ctcaaaaaac caaggcatag
721 aggaagcttt aaaaaatcgc aattttactg tagaaaaaat gagtgctgaa attaatgaga
781 taattcgtgt gttacaactc acctcttggg atgaagatgc ctgggccagc aaggacactg
841 aagccatgaa gagagcattg gcctccatag actccaaact gaaccaggcc aaaggttggc
901 tccgtgaccc tagtgcctcc ccaggggatg ctggtgagca ggccatcaga cagatcttag
961 atgaagctgg aaaagttggt gaactctgtg caggcaaaga acgcagggag attctgggaa
1021 cttgcaaaat gctagggcag atgactgatc aagtggctga cctccgtgcc agaggacaag
1081 gatcctcacc ggtggccatg cagaaagctc agcaggtatc tcagggtctg gatgtgctca
1141 cagcaaaagt ggaaaatgca gctcgcaagc tggaagccat gaccaactca aagcagagca
1201 ttgcaaagaa gatcgatgct gctcagaact ggcttgcaga tccaaatggt ggaccggaag
1261 gagaagagca gattcgaggt gctttggctg aagctcggaa aatagcagaa ttatgtgatg
1321 atcctaaaga aagagatgac attctacgtt cccttgggga aatatctgct ctgacttcta
1381 aattagcaga tctacgaaga caggggaaag gagattctcc agaggctcga gccttggcca
1441 aacaggtggc cacggccctg cagaacctgc agaccaaaac caaccgggct gtggccaaca
1501 gcagaccggc caaagcagct gtacaccttg agggcaagat tgagcaagca cagcggtgga
1561 ttgataatcc cacagtggat gaccgtggag tcggtcaggc tgccatccgg gggcttgtgg
1621 ccgaagggca tcgtctggct aatgttatga tggggcctta tcggcaagat cttctcgcca
1681 agtgtgaccg agtggaccag ctgacagccc agctggctga cctggctgcc agaggggaag
1741 gggagagtcc tcaggcacga gcacttgcat ctcagctcca agactcctta aaggatctaa
1801 aagctcggat gcaggaggcc atgactcagg aagtgtcaga tgttttcagc gataccacaa
1861 ctcccatcaa gctgttggca gtggcagcca cggcgcctcc tgatgcgcct aacagggaag
1921 aggtatttga tgagagggca gctaactttg aaaaccattc aggaaagctt ggtgctacgg
1981 ccgagaaggc ggctgcggtt ggtactgcta ataaatcaac agtggaaggc attcaggcct
2041 cagtgaagac ggcccgagaa ctcacacccc aggtggtctc ggctgctcgt atcttactta
2101 ggaaccctgg aaatcaagct gcttatgaac attttgagac catgaagaac cagtggatcg
2161 ataatgttga aaaaatgaca gggctggtgg acgaagccat tgataccaaa tctctgttgg
2221 atgcttcaga agaagcaatt aaaaaagacc tggacaagtg caaggtagct atggccaaca
2281 ttcagcctca gatgctggtt gctggggcaa ccagtattgc tcgtcgggcc aaccggatcc
2341 tgctggtggc taagagggag gtggagaatt ccgaggatcc caagttccgt gaggctgtga
2401 aagctgcctc tgatgaattg agcaaaacca tctccccaat ggtgatggat gcaaaagctg
2461 tggctggaaa catttccgac cctggactgc aaaagagctt cctggactca ggatatcgga
2521 tcctgggagc tgtggccaag gtcagagaag ccttccaacc tcaggagcct gacttcccgc
2581 cgcctccacc agaccttgaa caactccgac taacagatga gcttgctcct cccaaaccac
2641 ctctgcctga aggtgaggtc cctccaccta ggcctccacc accagaggaa aaggatgaag
2701 agttccctga gcagaaggcc ggggaggtga ttaaccagcc aatgatgatg gctgccagac
2761 agctccatga tgaagctcgc aaatggtcca gcaagggcaa tgacatcatt gcagcagcca
2821 agcgcatggc tctgctgatg gctgagatgt ctcggctggt aagagggggc agtggtacca
2881 agcgggcact cattcagtgt gccaaggaca tcgccaaggc ctcagatgag gtgactcggt
2941 tggccaagga ggttgccaag cagtgcacag ataaacggat tagaaccaac ctcttacagg
3001 tatgtgagcg aatcccaacc ataagcaccc agctcaaaat cctgtccaca gtgaaggcca
3061 ccatgctggg ccggaccaac atcagtgatg aggagtctga gcaggccaca gagatgctgg
3121 ttcacaatgc ccagaacctc atgcagtctg tgaaggagac tgtgcgggaa gctgaagctg
3181 cttcaatcaa aattcgaaca gatgctggat ttacactgcg ctgggttaga aagactccct
3241 ggtaccagta ggcacctggc tgagcctggc tggcacagaa acctctacta aaaagaagga
3301 aaatgatctg agtcccagga gctgcccaga gttgctggga gctgaaaaat cacatcctgg
3361 cctggcacat cagaaaggaa tgggggcctc ttcaaattag aagacattta tactcttttt
3421 tcatggacac tttgaaatgt gtttctgtat aaagcctgta ttctcaaaca cagttacact
3481 tgtgcaccct ctatcccaat aggcagactg ggtttctagc ccatggactt cacataagct
3541 cagaatccaa gtgaacacta gccagacact ctgctctgcc cttgttccct aggggacact
3601 tccctctgtt tctctttcct tggctcccat tcactcttcc agaatcccaa gacccagggc
3661 ccaggcaaat cagttactaa gaagaaaatt gctgtgcctc ccaaaattgt tttgagcttt
3721 ccatgttgct gccaaccata ccttccttcc ctgggctgtg ctacctgggt ccttttcaga
3781 agtgagcttt gctgctacag gggaaggtgg cctctgtgga gccccagcat atgggggcct
3841 ggattcattt cctgcccttc ctcagtttaa tccttctagt ttcccacaat ataaaactgt
3901 acttcactgt caggaagaaa tcacagaatc atatgattct gcttttacca tgcccctgag
3961 caatgtctgt gctagggaaa ctccccgtcc catatcctgc ctcagcccgc caaggtagcc
4021 atcccatgaa cacactgtgt cctggtgctc tctgccactg gaagggcaga gtagccaggg
4081 tgtggccctg ccatcttccc agcagggcca ctcccggcac tccatgctta gtcactgcct
4141 gcagaggtct gtgctgaggc cttatcattc attcttagct cttaattgtt cattttgagc
4201 tgaaatgctg cattttaatt ttaaccaaaa catgtctcct atatcctggt ttttgtagcc
4261 ttcctccaca tcctttctaa acaagatttt aaagacatgt aggtgtttgt tcatctgtaa
4321 ctctaaaaga tcctttttaa attcagtcct aagaaagagg agtgcttgtc ccctaagagt
4381 gtttaatggc aaggcagccc tgtctgaagg acacttcctg cctaagggag agtggtattt
4441 gcagactaga attctagtgc tgctgaagat gaatcaatgg gaaatactac tcctgtaatt
4501 cctacctccc tgcaaccaac tacaaccaag ctctctgcat ctactcccaa gtatggggtt
4561 caagagagta atgggtttca tatttcttat caccacagta agttcctact aggcaaaatg
4621 agagggcagt gtttcctttt tggtacttat tactgctaag tatttcccag cacatgaaac
4681 cttatttttt ccaaagccag aaccagatga gtaaaggagt aagaaccttg cctgaacatc
4741 cttccttccc acccatcgct gtgtgttagt tcccaacatc gaatgtgtac aacttaagtt
4801 ggtcctttac actcaggctt tcactatttc ctttaaaatg aggatgatta ttttcaaggc
4861 cctcagcata tttgtatagt tgcttgcctg atataaatgc aatattaatg cctttaaagt
4921 atgaatctat gccaaagatc acttgttgtt ttactaaaga aagattactt agaggaaata
4981 agaaaaatca tgtttgctct cccggttctt ccagtggttt gagacactgg tttacacttt
5041 atgccggatg tgcttttctc caatatcagt gctcgagaca cagtgaagca aattaaaaaa
5101 aa
//