LOCUS       HUMPF4V1A               1468 bp    DNA     linear   HUM 07-JAN-1995
DEFINITION  Human platelet factor 4 varation 1 (PF4var1) gene, complete cds.
ACCESSION   M26167
VERSION     M26167.1
KEYWORDS    platelet factor 4.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Green,C.J., Charles,R.S., Edwards,B.F. and Johnson,P.H.
  TITLE     Identification and characterization of PF4varl, a human gene
            variant of platelet factor 4
  JOURNAL   Mol. Cell. Biol. 9 (4), 1445-1451 (1989)
   PUBMED   2725510
FEATURES             Location/Qualifiers
     source          1..1468
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
     misc_feature    58..66
                     /gene="PF4var1"
                     /note="T-rich region"
     promoter        184..190
                     /gene="PF4var1"
     gene            join(214..380,699..825,951..1411)
                     /gene="PF4var1"
     mRNA            join(214..380,699..825,951..1411)
                     /gene="PF4var1"
                     /product="platelet factor 4"
     prim_transcript 214..1411
                     /gene="PF4var1"
                     /note="exons and introns"
     exon            214..380
                     /gene="PF4var1"
                     /product="platelet factor 4"
                     /number=1
     CDS             join(281..380,699..825,951..1038)
                     /gene="PF4var1"
                     /note="precursor protein"
                     /codon_start=1
                     /product="platelet factor 4"
                     /protein_id="AAA60067.1"
                     /db_xref="GI:292390"
                     /translation="MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQC
                     LCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHL
                     ES"
     sig_peptide     join(281..380,699..700)
                     /gene="PF4var1"
                     /note="leader sequence"
     mat_peptide     join(701..825,951..1035)
                     /gene="PF4var1"
                     /product="platelet factor 4"
     intron          381..698
                     /gene="PF4var1"
                     /number=1
     exon            699..825
                     /gene="PF4var1"
                     /product="platelet factor 4"
                     /number=2
     intron          826..950
                     /gene="PF4var1"
                     /number=2
     exon            951..1411
                     /gene="PF4var1"
                     /product="platelet factor 4"
                     /number=3
     polyA_signal    1126..1131
                     /gene="PF4var1"
     polyA_signal    1258..1263
                     /gene="PF4var1"
     misc_feature    1303..1308
                     /gene="PF4var1"
                     /note="GT cluster"
     polyA_signal    1371..1377
                     /gene="PF4var1"
BASE COUNT          363 a          380 c          333 g          392 t
ORIGIN      
        1 gaggttggag gtatgcatct ttgtaccacc tcctagccaa ggcaggtgcc cccagccttt
       61 tgttttgtaa tcttggctgg ccagagtctg agtcttcata gcagtgtctt agctcctgca
      121 ccacagttcc tcgctgtcca caccaggctt ccggactgga aggacagtgg gacagtgacg
      181 ggggataaaa gaagcctggt gaggccagga gtcactgcct gcagaacccc agcccgactt
      241 tccctgcgca ctgggatcct gctggaacct cagctgcaac atgagctccg cagccaggtc
      301 ccgcctcacc cgcgccaccc gccaggagat gctgttcttg gcgttgctgc tcctgccagt
      361 tgtggtcgcc ttcgccagag gtgagagcag aaaccaggct gggagggcca gcagcggcga
      421 gggggagtcc gggaagccct ggggctggga ggaatcctct aggatcatga tcgcagctgc
      481 tcttattgcg cgcgtgctga gtctgcgggt acagtgccag gcactgcacg tgcacctcgc
      541 cacctgctca gcacaacctc tgtctgagag aggtctgatt tacggctaag gaaaagaaag
      601 ctgaaggtag tggaaaaggt ccctaaagta tctctggcta ctcaggagtc acaactccca
      661 cccctcctcc tctcttactc cctccctttc cccctcagct gaagctgaag aagatgggga
      721 cctgcagtgc ctgtgtgtga agaccacctc ccaggtccgt cccaggcaca tcaccagcct
      781 ggaggtgatc aaggccggac cccactgccc cactgcccaa ctcatgtgag tcctcgcact
      841 gcatcagtta gtgctcccgc tccgtgcctc ctctgcccat ccctccccct tctaatgcca
      901 tttgcaaacc caaggactga aagtcacgtc tcttctcttt tccctgccag agccacgctg
      961 aagaatggga ggaaaatttg cttggatctg caagccctgc tgtacaagaa aatcattaag
     1021 gaacatttgg agagttagct actagctgcc taagtgtgca ctttcaatct aactgtgaaa
     1081 gaatcttctg atgtttgtat tatccttctt atattatatt aacaaaataa atcaagttgt
     1141 ggtatagtca atctatttct taataatact gcaaaaataa tgctgacaca tcacaatttc
     1201 atattttaaa atttccagaa ttttaagcaa aaagcattat gaaggaaggc ttggtttaat
     1261 aaagactgat tttgttcagt gttatatgtt agctgataca tatttgttca tttatgtgat
     1321 tgcagtactt tatagctaca tatttacctt gaatgttaca attagcttgc caataaatat
     1381 tagtagctct taagcattac atctgcaaag atatatatat atatatatat atatatattt
     1441 tttttttttg ccatgttaag caacacat
//