LOCUS HUMRBSY79 480 bp mRNA linear HUM 22-SEP-2008 DEFINITION Human mutated retinoblastoma susceptibility (RB) mRNA, complete cds. ACCESSION M19701 J03809 VERSION M19701.1 KEYWORDS retinoblastoma susceptibility. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 480) AUTHORS Lee,E.Y., Bookstein,R., Young,L.J., Lin,C.J., Rosenfeld,M.G. and Lee,W.H. TITLE Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (16), 6017-6021 (1988) PUBMED 3413073 COMMENT Draft entry and computer-readable sequence kindly provided by E.Y.-H.P.Lee, 15-JUL-1988 The deletion spans exons 2-6 of the normal gene. FEATURES Location/Qualifiers source 1..480 /db_xref="H-InvDB:HIT000194695" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="13q14.2" gene 1..480 /gene="RB1" CDS 139..300 /gene="RB1" /codon_start=1 /product="mutated retinoblastoma protein" /protein_id="AAA60259.1" /db_xref="GDB:G00-118-734" /translation="MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPL VRGSITNGR" misc_recomb 275..276 /gene="RB1" BASE COUNT 111 a 151 c 125 g 93 t ORIGIN 1 ttccggtttt tctcagggga cgttgaaatt atttttgtaa cgggagtcgg gagaggacgg 61 ggcgtgcccc gcgtgcgcgc gcgtcgtcct ccccggcgct cctccacagc tcgctggctc 121 ccgccgcgga aaggcgtcat gccgcccaaa accccccgaa aaacggccgc caccgccgcc 181 gctgccgccg cggaaccccc ggcaccgccg ccgccgcccc ctcctgagga ggacccagag 241 caggacagcg gcccggagga cctgcctctc gtcaggggaa gtattacaaa tggaagatga 301 tctggtgatt tcatttcagt taatgctatg tgtccttgac tattttatta aactctcacc 361 tcccatgttg ctcaaagaac catataaaac agctgttata cccattaatg gttcacctcg 421 aacacccagg cgaggtcaga acaggagtgc acggatagca aaacaactag aaaatgatac //