LOCUS HUMBCL2C 6030 bp mRNA linear HUM 27-APR-1993
DEFINITION Human bcl-2 mRNA.
ACCESSION M14745
VERSION M14745.1
KEYWORDS c-myc proto-oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6030)
AUTHORS Cleary,M.L., Smith,S.D. and Sklar,J.
TITLE Cloning and structural analysis of cDNAs for bcl-2 and a hybrid
bcl-2/immunoglobulin transcript resulting from the t(14;18)
translocation
JOURNAL Cell 47 (1), 19-28 (1986)
PUBMED 2875799
COMMENT Original source text: Human common acute lymphoblastic leukemia
cell line cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..6030
/db_xref="H-InvDB:HIT000194357"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 32..751
/note="bcl-2 protein"
/codon_start=1
/protein_id="AAA35591.1"
/translation="MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAP
APGIFSSQPGHTPHTAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGD
DFSRRYRRDFAEMSRQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVE
SVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLK
TLLSLALVGACITLGAYLGHK"
BASE COUNT 1668 a 1247 c 1386 g 1729 t
ORIGIN Chromosome 18.
1 gttggccccc gttacttttc ctctgggaaa tatggcgcac gctgggagaa cagggtacga
61 taaccgggag atagtgatga agtacatcca ttataagctg tcgcagaggg gctacgagtg
121 ggatgcggga gatgtgggcg ccgcgccccc gggggccgcc cccgcgccgg gcatcttctc
181 ctcgcagccc gggcacacgc cccatacagc cgcatcccgg gacccggtcg ccaggacctc
241 gccgctgcag accccggctg cccccggcgc cgccgcgggg cctgcgctca gcccggtgcc
301 acctgtggtc cacctgaccc tccgccaggc cggcgacgac ttctcccgcc gctaccgccg
361 cgacttcgcc gagatgtcca ggcagctgca cctgacgccc ttcaccgcgc ggggacgctt
421 tgccacggtg gtggaggagc tcttcaggga cggggtgaac tgggggagga ttgtggcctt
481 ctttgagttc ggtggggtca tgtgtgtgga gagcgtcaac cgggagatgt cgcccctggt
541 ggacaacatc gccctgtgga tgactgagta cctgaaccgg cacctgcaca cctggatcca
601 ggataacgga ggctgggatg cctttgtgga actgtacggc cccagcatgc ggcctctgtt
661 tgatttctcc tggctgtctc tgaagactct gctcagtttg gccctggtgg gagcttgcat
721 caccctgggt gcctatctgg gccacaagtg aagtcaacat gcctgcccca aacaaatatg
781 caaaaggttc actaaagcag tagaaataat atgcattgtc agtgatgttc catgaaacaa
841 agctgcaggc tgtttaagaa aaaataacac acatataaac atcacacaca cagacagaca
901 cacacacaca caacaattaa cagtcttcag gcaaaacgtc gaatcagcta tttactgcca
961 aagggaaata tcatttattt tttacattat taagaaaaaa agatttattt atttaagaca
1021 gtcccatcaa aactcctgtc tttggaaatc cgaccactaa ttgccaagca ccgcttcgtg
1081 tggctccacc tggatgttct gtgcctgtaa acatagattc gctttccatg ttgttggccg
1141 gatcaccatc tgaagagcag acggatggaa aaaggacctg atcattgggg aagctggctt
1201 tctggctgct ggaggctggg gagaaggtgt tcattcactt gcatttcttt gccctggggg
1261 ctgtgatatt aacagaggga gggttcctgt ggggggaagt ccatgcctcc ctggcctgaa
1321 gaagagactc tttgcatatg actcacatga tgcatacctg gtgggaggaa aagagttggg
1381 aacttcagat ggacctagta cccactgaga tttccacgcc gaaggacagc gatgggaaaa
1441 atgcccttaa atcataggaa agtatttttt taagctacca attgtgccga gaaaagcatt
1501 ttagcaattt atacaatatc atccagtacc ttaagccctg attgtgtata ttcatatatt
1561 ttggatacgc accccccaac tcccaatact ggctctgtct gagtaagaaa cagaatcctc
1621 tggaacttga ggaagtgaac atttcggtga cttccgcatc aggaaggcta gagttaccca
1681 gagcatcagg ccgccacaag tgcctgcttt taggagaccg aagtccgcag aacctgcctg
1741 tgtcccagct tggaggcctg gtcctggaac tgagccgggg ccctcactgg cctcctccag
1801 ggatgatcaa cagggcagtg tggtctccga atgtctggaa gctgatggag ctcagaattc
1861 cactgtcaag aaagagcagt agaggggtgt ggctgggcct gtcaccctgg ggccctccag
1921 gtaggcccgt tttcacgtgg agcatgggag ccacgaccct tcttaagaca tgtatcactg
1981 tagagggaag gaacagaggc cctgggccct tcctatcaga aggacatggt gaaggctggg
2041 aacgtgagga gaggcaatgg ccacggccca ttttggctgt agcacatggc acgttggctg
2101 tgtggccttg gcccacctgt gagtttaaag caaggcttta aatgactttg gagagggtca
2161 caaatcctaa aagaagcatt gaagtgaggt gtcatggatt aattgacccc tgtctatgga
2221 attacatgta aaacattatc ttgtcactgt agtttggttt tatttgaaaa cctgacaaaa
2281 aaaaagttcc aggtgtggaa tatgggggtt atctgtacat cctggggcat taaaaaaaaa
2341 atcaatggtg gggaactata aagaagtaac aaaagaagtg acatcttcag caaataaact
2401 aggaaatttt tttttcttcc agtttagaat cagccttgaa acattgatgg aataactctg
2461 tggcattatt gcattatata ccatttatct gtattaactt tggaatgtac tctgttcaat
2521 gtttaatgct gtggttgata tttcgaaagc tgctttaaaa aaatacatgc atctcagcgt
2581 ttttttgttt ttaattgtat ttagttatgg cctatacact atttgtgagc aaaggtgatc
2641 gttttctgtt tgagattttt atctcttgat tcttcaaaag cattctgaga aggtgagata
2701 agccctgagt ctcagctacc taagaaaaac ctggatgtca ctggccactg aggagctttg
2761 tttcaaccaa gtcatgtgca tttccacgtc aacagaattg tttattgtga cagttatatc
2821 tgttgtccct ttgaccttgt ttcttgaagg tttcctcgtc cctgggcaat tccgcattta
2881 attcatggta ttcaggatta catgcatgtt tggttaaacc catgagattc attcagttaa
2941 aaatccagat ggcaaatgac cagcagattc aaatctatgg tggtttgacc tttagagagt
3001 tgctttacgt ggcctgtttc aacacagacc cacccagagc cctcctgccc tccttccgcg
3061 ggggctttct catggctgtc cttcagggtc ttcctgaaat gcagtggtgc ttacgctcca
3121 ccaagaaagc aggaaacctg tggtatgaag ccagacctcc ccggcgggcc tcagggaaca
3181 gaatgatcag acctttgaat gattctaatt tttaagcaaa atattatttt atgaaaggtt
3241 tacattgtca aagtgatgaa tatggaatat ccaatcctgt gctgctatcc tgccaaaatc
3301 attttaatgg agtcagtttg cagtatgctc cacgtggtaa gatcctccaa gctgctttag
3361 aagtaacaat gaagaacgtg gacgctttta atataaagcc tgttttgtct tctgttgttg
3421 ttcaaacggg attcacagag tatttgaaaa atgtatatat attaagaggt cacgggggct
3481 aattgctggc tggctgcctt ttgctgtggg gttttgttac ctggttttaa taacagtaaa
3541 tgtgcccagc ctcttggccc cagaactgta cagtattgtg gctgcacttg ctctaagagt
3601 agttgatgtt gcattttcct tattgttaaa aacatgttag aagcaatgaa tgtatataaa
3661 agcctcaact agtcattttt ttctcctctt cttttttttc attatatcta attattttgc
3721 agttgggcaa cagagaacca tccctatttt gtattgaaga gggattcaca tctgcatctt
3781 aactgctctt tatgaatgaa aaaacagtcc tctgtatgta ctcctcttta cactggccag
3841 ggtcagagtt aaatagagta tatgcacttt ccaaattggg gacaagggct ctaaaaaaag
3901 ccccaaaagg agaagaacat ctgagaacct cctcggccct cccagtccct cgctgcacaa
3961 atactccgca agagaggcca gaatgacagc tgacagggtc tatggccatc gggtcgtctc
4021 cgaagatttg gcaggggcag aaaactctgg caggcttaag atttggaata aagtcacaga
4081 atcaaggaag cacctcaatt tagttcaaac aagacgccaa cattctctcc acagctcact
4141 tacctctctg tgttcagatg tggccttcca tttatatgtg atctttgttt tattagtaaa
4201 tgcttatcat ctaaagatgt agctctggcc cagtgggaaa aattaggaag tgattataaa
4261 tcgagaggag ttataataat caagattaaa tgtaaataat cagggcaatc ccaacacatg
4321 tctagctttc acctccagga tctattgagt gaacagaatt gcaaatagtc tctatttgta
4381 attgaactta tcctaaaaca aatagtttat aaatgtgaac ttaaactcta attaattcca
4441 actgtacttt taaggcagtg gctgttttta gactttctta tcacttatag ttagtaatgt
4501 acacctactc tatcagagaa aaacaggaaa ggctcgaaat acaagccatt ctaaggaaat
4561 tagggagtca gttgaaattc tattctgatc ttattctgtg gtgtcttttg cagcccagac
4621 aaatgtggtt acacactttt taagaaatac aattctacat tgtcaagctt atgaaggttc
4681 caatcagatc tttattgtta ttcaatttgg atctttcagg gatttttttt ttaaattatt
4741 atgggacaaa ggacatttgt tggaggggtg ggagggagga acaattttta aatataaaac
4801 attcccaagt ttggatcagg gagttggaag ttttcagaat aaccagaact aagggtatga
4861 aggacctgta ttggggtcga tgtgatgcct ctgcgaagaa ccttgtgtga caaatgagaa
4921 acattttgaa gtttgtggta cgacctttag attccagaga catcagcatg gctcaaagtg
4981 cagctccgtt tggcagtgca atggtataaa tttcaagctg gatatgtcta atgggtattt
5041 aaacaataaa tgtgcagttt taactaacag gatatttaat gacaaccttc tggttggtag
5101 ggacatctgt ttctaaatgt ttattatgta caatacagaa aaaaatttta taaaattaag
5161 caatgtgaaa ctgaattgga gagtgataat acaagtcctt tagtcttacc cagtgaatca
5221 ttctgttcca tgtctttgga caaccatgac cttggacaat catgaaatat gcatctcact
5281 ggatgcaaag aaaatcagat ggagcatgaa tggtactgta ccggttcatc tggactgccc
5341 cagaaaaata acttcaagca aacatcctat caacaacaag gttgttctgc ataccaagct
5401 gagcacagaa gatgggaaca ctggtggagg atggaaaggc tcgctcaatc aagaaaattc
5461 tgagactatt aataaataag actgtagtgt agatactgag taaatccatg cacctaaacc
5521 ttttggaaaa tctgccgtgg gccctccaga tagctcattt cattaagttt ttccctccaa
5581 ggtagaattt gcaagagtga cagtggattg catttctttt ggggaagctt tcttttggtg
5641 gttttgttta ttataccttc ttaagttttc aaccaaggtt tgcttttgtt ttgagttact
5701 ggggttattt ttgttttaaa taaaaataag tgtacaataa gtgtttttgt attgaaagct
5761 tttgttatca agattttcat acttttacct tccatggctc tttttaagat tgatactttt
5821 aagaggtggc tgatattctg caacactgta cacataaaaa atacggtaag gatactttac
5881 atggttaagg taaagtaagt ctccagttgg ccaccattag ctataatggc actttgtttg
5941 tgttgttgga aaaagtcaca ttgccattaa actttccttg tctgtctagt taatattgtg
6001 aagaaaaata aagtacagtg tgagatactg
//