LOCUS HUMGHN 2657 bp DNA linear HUM 29-APR-1996
DEFINITION Human growth hormone gene (HGH-N), complete cds.
ACCESSION M13438
VERSION M13438.1
KEYWORDS Alu repeat; growth hormone; hormone; repeat region.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2657)
AUTHORS Seeburg,P.H.
TITLE The human growth hormone gene family: nucleotide sequences show
recent divergence and predict a new polypeptide hormone
JOURNAL DNA 1 (3), 239-249 (1982)
PUBMED 7169009
COMMENT Original source text: Homo sapiens (clone: HGH-N.) (tissue library:
Lawn et al.) DNA.
The Alu family sequences are known to be transcribed by RNA
polymerase III and in [1] is inserted such that transcription would
be from the opposite strand to that of the growth hormone genes.
FEATURES Location/Qualifiers
source 1..2657
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="17q21-qter"
/clone="HGH-N."
/tissue_lib="Lawn et al."
gene 497..2129
/gene="GH-N"
prim_transcript 497..2129
/gene="GH-N"
/note="HGH-N mRNA"
exon 497..568
/gene="GH-N"
/number=1
CDS join(559..568,828..988,1196..1315,1409..1573,1827..2024)
/gene="GH-N"
/note="precursor"
/codon_start=1
/product="growth hormone"
/protein_id="AAA98618.1"
/translation="MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAH
RLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELL
RISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPR
TGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF"
sig_peptide join(559..568,828..895)
/gene="GH-N"
mat_peptide join(896..988,1196..1315,1409..1573,1827..2021)
/gene="GH-N"
/product="growth hormone"
intron 569..827
/gene="GH-N"
/number=1
exon 828..988
/gene="GH-N"
/number=2
intron 989..1195
/gene="GH-N"
/number=2
exon 1196..1315
/gene="GH-N"
/number=3
intron 1316..1408
/gene="GH-N"
/number=3
exon 1409..1573
/gene="GH-N"
/number=4
intron 1574..1826
/gene="GH-N"
/number=4
exon 1827..2129
/gene="GH-N"
/number=5
regulatory 2111..2116
/regulatory_class="polyA_signal_sequence"
/gene="GH-N"
repeat_region complement(2228..2501)
/rpt_family="Alu"
BASE COUNT 598 a 741 c 734 g 584 t
ORIGIN 1 bp upstream of EcoRI site.
1 gaattcagga ctgaatcgtg ctcacaaccc ccacaatcta ttggctgtgc ttggcccctt
61 ttcccaacac acacattctg tctggtgggt ggaggttaaa catgcgggga ggaggaaagg
121 gataggatag agaatgggat gtggtcggta gggggtctca aggactggcc tatcctgaca
181 tccttcgccc gcgtgcaggt tggccaccat ggcctgcggc cagagggcac ccacgtgacc
241 cttaaagaga ggacaagttg ggtggtatct ctggctgaca ctctgtgcac aaccctcaca
301 acactggtga cggtgggaag ggaaagatga caagccaggg ggcatgatcc cagcatgtgt
361 gggaggagct tctaaattat ccattagcac aagcccgtca gtggccccat gcataaatgt
421 agcacagaaa caggtggggt caacagtggg agagaagggg ccagggtata aaaagggccc
481 acaagagacc agctcaagga tcccaaggcc caactccccg aaccactcag ggtcctgtgg
541 acagctcacc tagctgcaat ggctacaggt aagcgcccct aaaatccctt tggcacaatg
601 tgtcctgagg ggagaggcag cgacctgtag atgggacggg ggcactaacc ctcagggttt
661 ggggttctga atgtgagtat cgccatctaa gcccagtatt tggccaatct cagaaagctc
721 ctggctccct ggaggatgga gagagaaaaa caaacagctc ctggagcagg gagagtgttg
781 gcctcttgct ctccggctcc ctctgttgcc ctctggtttc tccccaggct cccggacgtc
841 cctgctcctg gcttttggcc tgctctgcct gccctggctt caagagggca gtgccttccc
901 aaccattccc ttatccaggc tttttgacaa cgctatgctc cgcgcccatc gtctgcacca
961 gctggccttt gacacctacc aggagtttgt aagctcttgg ggaatgggtg cgcatcaggg
1021 gtggcaggaa ggggtgactt tcccccgctg gaaataagag gaggagacta aggagctcag
1081 ggtttttccc gaccgcgaaa atgcaggcag atgagcacac gctgagctag gttcccagaa
1141 aagtaaaatg ggagcaggtc tcagctcaga ccttggtggg cggtccttct cctaggaaga
1201 agcctatatc ccaaaggaac agaagtattc attcctgcag aacccccaga cctccctctg
1261 tttctcagag tctattccga caccctccaa cagggaggaa acacaacaga aatccgtgag
1321 tggatgcctt ctccccaggc ggggatgggg gagacctgta gtcagagccc ccgggcagca
1381 cagccaatgc ccgtccttgc ccctgcagaa cctagagctg ctccgcatct ccctgctgct
1441 catccagtcg tggctggagc ccgtgcagtt cctcaggagt gtcttcgcca acagcctggt
1501 gtacggcgcc tctgacagca acgtctatga cctcctaaag gacctagagg aaggcatcca
1561 aacgctgatg ggggtgaggg tggcgccagg ggtccccaat cctggagccc cactgacttt
1621 gagagactgt gttagagaaa cactggctgc cctcttttta gcagtcaggc cctgacccaa
1681 gagaactcac cttattcttc atttcccctc gtgaatcctc caggcctttc tctacactga
1741 aggggaggga ggaaaatgaa tgaatgagaa agggagggaa cagtacccaa gcgcttggcc
1801 tctccttctc ttccttcact ttgcagaggc tggaagatgg cagcccccgg actgggcaga
1861 tcttcaagca gacctacagc aagttcgaca caaactcaca caacgatgac gcactactca
1921 agaactacgg gctgctctac tgcttcagga aggacatgga caaggtcgag acattcctgc
1981 gcatcgtgca gtgccgctct gtggagggca gctgtggctt ctagctgccc gggtggcatc
2041 cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca gtgcccacca
2101 gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc ttctataata
2161 ttatggggtg gaggggggtg gtatggagca aggggcccaa gttgggaaga caacctgtag
2221 ggcctgcggg gtctattcgg gaaccaagct ggagtgcagt ggcacaatct tggctcactg
2281 caatctccgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag ttgttgggat
2341 tccaggcatg catgaccagg ctcagctaat ttttgttttt ttggtagaga cggggtttca
2401 ccatattggc caggctggtc tccaactcct aatctcaggt gatctaccca ccttggcctc
2461 ccaaattgct gggattacag gcgtgaacca ctgctccctt ccctgtcctt ctgattttaa
2521 aataactata ccagcaggag gacgtccaga cacagcatag gctacctgcc atggcccaac
2581 cggtgggaca tttgagttgc ttgcttggca ctgtcctctc atgcgttggg tccactcagt
2641 agatgcctgt tgaattc
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