LOCUS       HUMGHN                  2657 bp    DNA     linear   HUM 29-APR-1996
DEFINITION  Human growth hormone gene (HGH-N), complete cds.
ACCESSION   M13438
VERSION     M13438.1
KEYWORDS    Alu repeat; growth hormone; hormone; repeat region.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Seeburg,P.H.
  TITLE     The human growth hormone gene family: nucleotide sequences show
            recent divergence and predict a new polypeptide hormone
  JOURNAL   DNA 1 (3), 239-249 (1982)
   PUBMED   7169009
COMMENT     Original source text: Homo sapiens (clone: HGH-N.) (tissue library:
            Lawn et al.) DNA.
            The Alu family sequences are known to be transcribed by RNA
            polymerase III and in [1] is inserted such that transcription would
            be from the opposite strand to that of the growth hormone genes.
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="17q21-qter"
                     /clone="HGH-N."
                     /tissue_lib="Lawn et al."
     gene            497..2129
                     /gene="GH-N"
     prim_transcript 497..2129
                     /gene="GH-N"
                     /note="HGH-N mRNA"
     exon            497..568
                     /gene="GH-N"
                     /number=1
     CDS             join(559..568,828..988,1196..1315,1409..1573,1827..2024)
                     /gene="GH-N"
                     /note="precursor"
                     /codon_start=1
                     /product="growth hormone"
                     /protein_id="AAA98618.1"
                     /db_xref="GI:183157"
                     /translation="MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAH
                     RLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELL
                     RISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPR
                     TGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF"
     sig_peptide     join(559..568,828..895)
                     /gene="GH-N"
     mat_peptide     join(896..988,1196..1315,1409..1573,1827..2021)
                     /gene="GH-N"
                     /product="growth hormone"
     intron          569..827
                     /gene="GH-N"
                     /number=1
     exon            828..988
                     /gene="GH-N"
                     /number=2
     intron          989..1195
                     /gene="GH-N"
                     /number=2
     exon            1196..1315
                     /gene="GH-N"
                     /number=3
     intron          1316..1408
                     /gene="GH-N"
                     /number=3
     exon            1409..1573
                     /gene="GH-N"
                     /number=4
     intron          1574..1826
                     /gene="GH-N"
                     /number=4
     exon            1827..2129
                     /gene="GH-N"
                     /number=5
     polyA_signal    2111..2116
                     /gene="GH-N"
     repeat_region   complement(2228..2501)
                     /rpt_family="Alu"
BASE COUNT          598 a          741 c          734 g          584 t
ORIGIN      1 bp upstream of EcoRI site.
        1 gaattcagga ctgaatcgtg ctcacaaccc ccacaatcta ttggctgtgc ttggcccctt
       61 ttcccaacac acacattctg tctggtgggt ggaggttaaa catgcgggga ggaggaaagg
      121 gataggatag agaatgggat gtggtcggta gggggtctca aggactggcc tatcctgaca
      181 tccttcgccc gcgtgcaggt tggccaccat ggcctgcggc cagagggcac ccacgtgacc
      241 cttaaagaga ggacaagttg ggtggtatct ctggctgaca ctctgtgcac aaccctcaca
      301 acactggtga cggtgggaag ggaaagatga caagccaggg ggcatgatcc cagcatgtgt
      361 gggaggagct tctaaattat ccattagcac aagcccgtca gtggccccat gcataaatgt
      421 agcacagaaa caggtggggt caacagtggg agagaagggg ccagggtata aaaagggccc
      481 acaagagacc agctcaagga tcccaaggcc caactccccg aaccactcag ggtcctgtgg
      541 acagctcacc tagctgcaat ggctacaggt aagcgcccct aaaatccctt tggcacaatg
      601 tgtcctgagg ggagaggcag cgacctgtag atgggacggg ggcactaacc ctcagggttt
      661 ggggttctga atgtgagtat cgccatctaa gcccagtatt tggccaatct cagaaagctc
      721 ctggctccct ggaggatgga gagagaaaaa caaacagctc ctggagcagg gagagtgttg
      781 gcctcttgct ctccggctcc ctctgttgcc ctctggtttc tccccaggct cccggacgtc
      841 cctgctcctg gcttttggcc tgctctgcct gccctggctt caagagggca gtgccttccc
      901 aaccattccc ttatccaggc tttttgacaa cgctatgctc cgcgcccatc gtctgcacca
      961 gctggccttt gacacctacc aggagtttgt aagctcttgg ggaatgggtg cgcatcaggg
     1021 gtggcaggaa ggggtgactt tcccccgctg gaaataagag gaggagacta aggagctcag
     1081 ggtttttccc gaccgcgaaa atgcaggcag atgagcacac gctgagctag gttcccagaa
     1141 aagtaaaatg ggagcaggtc tcagctcaga ccttggtggg cggtccttct cctaggaaga
     1201 agcctatatc ccaaaggaac agaagtattc attcctgcag aacccccaga cctccctctg
     1261 tttctcagag tctattccga caccctccaa cagggaggaa acacaacaga aatccgtgag
     1321 tggatgcctt ctccccaggc ggggatgggg gagacctgta gtcagagccc ccgggcagca
     1381 cagccaatgc ccgtccttgc ccctgcagaa cctagagctg ctccgcatct ccctgctgct
     1441 catccagtcg tggctggagc ccgtgcagtt cctcaggagt gtcttcgcca acagcctggt
     1501 gtacggcgcc tctgacagca acgtctatga cctcctaaag gacctagagg aaggcatcca
     1561 aacgctgatg ggggtgaggg tggcgccagg ggtccccaat cctggagccc cactgacttt
     1621 gagagactgt gttagagaaa cactggctgc cctcttttta gcagtcaggc cctgacccaa
     1681 gagaactcac cttattcttc atttcccctc gtgaatcctc caggcctttc tctacactga
     1741 aggggaggga ggaaaatgaa tgaatgagaa agggagggaa cagtacccaa gcgcttggcc
     1801 tctccttctc ttccttcact ttgcagaggc tggaagatgg cagcccccgg actgggcaga
     1861 tcttcaagca gacctacagc aagttcgaca caaactcaca caacgatgac gcactactca
     1921 agaactacgg gctgctctac tgcttcagga aggacatgga caaggtcgag acattcctgc
     1981 gcatcgtgca gtgccgctct gtggagggca gctgtggctt ctagctgccc gggtggcatc
     2041 cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca gtgcccacca
     2101 gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc ttctataata
     2161 ttatggggtg gaggggggtg gtatggagca aggggcccaa gttgggaaga caacctgtag
     2221 ggcctgcggg gtctattcgg gaaccaagct ggagtgcagt ggcacaatct tggctcactg
     2281 caatctccgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag ttgttgggat
     2341 tccaggcatg catgaccagg ctcagctaat ttttgttttt ttggtagaga cggggtttca
     2401 ccatattggc caggctggtc tccaactcct aatctcaggt gatctaccca ccttggcctc
     2461 ccaaattgct gggattacag gcgtgaacca ctgctccctt ccctgtcctt ctgattttaa
     2521 aataactata ccagcaggag gacgtccaga cacagcatag gctacctgcc atggcccaac
     2581 cggtgggaca tttgagttgc ttgcttggca ctgtcctctc atgcgttggg tccactcagt
     2641 agatgcctgt tgaattc
//