LOCUS HUMFALD 1791 bp mRNA linear HUM 29-MAY-1996
DEFINITION Human fatty aldehyde dehydrogenase (FALDH) mRNA, complete cds.
ACCESSION L47162
VERSION L47162.1
KEYWORDS Sjogren-Larsson syndrome; aldehyde dehydrogenase; fatty aldehyde
dehydrogenase; microsomal.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1791)
AUTHORS De Laurenzi,V., Rogers,G.R., Hamrock,D.J., Marekov,L.N.,
Steinert,P.M., Compton,J.G., Markova,N. and Rizzo,W.B.
TITLE Sjogren-Larsson syndrome is caused by mutations in the fatty
aldehyde dehydrogenase gene
JOURNAL Nat. Genet. 12 (1), 52-57 (1996)
PUBMED 8528251
FEATURES Location/Qualifiers
source 1..1791
/db_xref="H-InvDB:HIT000193910"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="keratinocyte"
gene 1..1791
/gene="FALDH"
mRNA <1..1777
/gene="FALDH"
CDS 164..1621
/gene="FALDH"
/codon_start=1
/product="fatty aldehyde dehydrogenase"
/protein_id="AAB01003.1"
/translation="MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTA
IAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLY
IVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDK
DCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKES
PDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFG
PILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHF
TLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDW
GKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY"
polyA_site 1791
/gene="FALDH"
BASE COUNT 501 a 389 c 435 g 466 t
ORIGIN
1 ggcggacgga gcgagccctg ggcgagtgaa ttgtggctgt gggttgacgg tggagacacc
61 ccccggagag gcggagggaa gggaggcgag gctgcacctg catgcttccc gcctcccact
121 ccccagcgcc cccggaccgt gcagttctct gcaggaccag gccatggagc tcgaagtccg
181 gcgggtccga caggcgttcc tgtccggccg gtcgcgacct ctgcggtttc ggctgcagca
241 gctggaggcc ctgcggagga tggtgcagga gcgcgagaag gatatcctga cggccatcgc
301 cgccgacctg tgcaagagtg aattcaatgt gtacagtcag gaagtcatta ctgtccttgg
361 ggaaattgat tttatgcttg agaatcttcc tgaatgggtt actgctaaac cagttaagaa
421 gaacgtgctc accatgctgg atgaggccta tattcagcca cagcctctgg gagtggtgct
481 gataatcgga gcttggaatt accccttcgt tctcaccatt cagccactga taggagccat
541 cgctgcagga aatgctgtga ttataaagcc ttctgaactg agtgaaaata cagccaagat
601 cttggcaaag cttctccctc agtatttaga ccaggatctc tatattgtta ttaatggtgg
661 tgttgaggaa accacggagc tcctgaagca gcgatttgac cacattttct atacgggaaa
721 cactgcggtt ggcaaaattg tcatggaagc tgctgccaag catctgaccc ctgtgactct
781 tgaactggga gggaaaagtc catgttatat tgataaagat tgtgacctgg acattgtttg
841 cagacgcata acctggggaa aatacatgaa ttgtggccaa acctgcattg cacccgacta
901 tattctctgt gaagcatccc tccaaaatca aattgtatgg aagattaagg aaacagtgaa
961 ggaattttat ggagaaaata taaaagagtc tcctgattat gaaaggatca tcaatcttcg
1021 tcattttaag aggatactaa gtttgcttga aggacaaaag atagcttttg gtggggagac
1081 tgatgaggcc acacgctaca tagccccaac agtacttacc gatgttgatc ctaaaaccaa
1141 ggtgatgcaa gaagaaattt ttggaccaat tcttccaata gtgcctgtga aaaatgtaga
1201 tgaggccata aatttcataa atgaacgtga aaagcctctg gctctttatg tattttcgca
1261 taaccataag ctcatcaaac ggatgattga tgagacatcc agtggaggtg tcacaggcaa
1321 tgacgtcatt atgcacttca cgctcaactc tttcccattt ggaggagtgg gttccagtgg
1381 gatgggagct tatcacggaa aacatagttt tgatactttt tctcatcagc gtccctgttt
1441 attaaaaagt ttaaagagag aaggtgctaa caaactcaga tatcctccca acagccagtc
1501 aaaggtggat tgggggaaat tttttctctt gaaacggttc aacaaagaaa aactcggtct
1561 cctgttgctc actttcctgg gtattgtagc cgctgtgctt gtcaaggcag aatattactg
1621 aagaatgatc ctgttcaacc tcctagtgcc tctactgaat tattcctctt ttaaatggtt
1681 aatgaaccaa taatttttaa atcataccaa aaatagtaag aaaatatgca aacactctgt
1741 gatcaaactt aaaagtcatt gccattcatc attaataaaa gttgccattt c
//