LOCUS HUMS182R 2765 bp mRNA linear HUM 04-OCT-1995
DEFINITION Homo sapiens (clone cc33) S182 mRNA, complete cds.
ACCESSION L42110
VERSION L42110.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2765)
AUTHORS Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
Foncin,J.-F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
Polinsky,R.J., Wasco,W., Da Silva,H.A.R., Haines,J.L.,
Pericak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
Rommens,J.M. and St. George-Hyslop,P.H.
TITLE Cloning of a gene bearing missense mutations in early-onset
familial Alzheimer's disease
JOURNAL Nature 375 (6534), 754-760 (1995)
PUBMED 7596406
COMMENT On Jul 25, 1995 this sequence version replaced gi:897613.
Original source text: Homo sapiens (clone: cc33) fetus brain cDNA
to mRNA.
FEATURES Location/Qualifiers
source 1..2765
/db_xref="H-InvDB:HIT000193798"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="14q24.3"
/clone="cc33"
/tissue_type="brain"
/dev_stage="fetus"
/germline
gene 1..2765
/gene="S182"
mRNA 1..2765
/gene="S182"
/note="map location near D14S77, D14S277, and D14S268"
5'UTR 1..248
/gene="S182"
CDS 249..1652
/gene="S182"
/codon_start=1
/protein_id="AAB46416.1"
/translation="MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSL
GHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKS
VSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYK
VIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGP
LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQ
ERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDG
GFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVL
VGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATD
YLVQPFMDQLAFHQFYI"
3'UTR 1650..2765
/gene="S182"
polyA_site 2765
/gene="S182"
BASE COUNT 715 a 624 c 652 g 773 t
ORIGIN
1 tgggacaggc agctccgggg tccgcggttt cacatcggaa acaaaacagc ggctggtctg
61 gaaggaacct gagctacgag ccgcggcggc agcggggcgg cggggaagcg tatacctaat
121 ctgggagcct gcaagtgaca acagcctttg cggtccttag acagcttggc ctggaggaga
181 acacatgaaa gaaagaacct caagaggctt tgttttctgt gaaacagtat ttctatacag
241 ttgctccaat gacagagtta cctgcaccgt tgtcctactt ccagaatgca cagatgtctg
301 aggacaacca cctgagcaat actgtacgta gccagaatga caatagagaa cggcaggagc
361 acaacgacag acggagcctt ggccaccctg agccattatc taatggacga ccccagggta
421 actcccggca ggtggtggag caagatgagg aagaagatga ggagctgaca ttgaaatatg
481 gcgccaagca tgtgatcatg ctctttgtcc ctgtgactct ctgcatggtg gtggtcgtgg
541 ctaccattaa gtcagtcagc ttttataccc ggaaggatgg gcagctaatc tataccccat
601 tcacagaaga taccgagact gtgggccaga gagccctgca ctcaattctg aatgctgcca
661 tcatgatcag tgtcattgtt gtcatgacta tcctcctggt ggttctgtat aaatacaggt
721 gctataaggt catccatgcc tggcttatta tatcatctct attgttgctg ttcttttttt
781 cattcattta cttgggggaa gtgtttaaaa cctataacgt tgctgtggac tacattactg
841 ttgcactcct gatctggaat tttggtgtgg tgggaatgat ttccattcac tggaaaggtc
901 cacttcgact ccagcaggca tatctcatta tgattagtgc cctcatggcc ctggtgttta
961 tcaagtacct ccctgaatgg actgcgtggc tcatcttggc tgtgatttca gtatatgatt
1021 tagtggctgt tttgtgtccg aaaggtccac ttcgtatgct ggttgaaaca gctcaggaga
1081 gaaatgaaac gctttttcca gctctcattt actcctcaac aatggtgtgg ttggtgaata
1141 tggcagaagg agacccggaa gctcaaagga gagtatccaa aaattccaag tataatgcag
1201 aaagcacaga aagggagtca caagacactg ttgcagagaa tgatgatggc gggttcagtg
1261 aggaatggga agcccagagg gacagtcatc tagggcctca tcgctctaca cctgagtcac
1321 gagctgctgt ccaggaactt tccagcagta tcctcgctgg tgaagaccca gaggaaaggg
1381 gagtaaaact tggattggga gatttcattt tctacagtgt tctggttggt aaagcctcag
1441 caacagccag tggagactgg aacacaacca tagcctgttt cgtagccata ttaattggtt
1501 tgtgccttac attattactc cttgccattt tcaagaaagc attgccagct cttccaatct
1561 ccatcacctt tgggcttgtt ttctactttg ccacagatta tcttgtacag ccttttatgg
1621 accaattagc attccatcaa ttttatatct agcatatttg cggttagaat cccatggatg
1681 tttcttcttt gactataacc aaatctgggg aggacaaagg tgattttcct gtgtccacat
1741 ctaacaaagt caagattccc ggctggactt ttgcagcttc cttccaagtc ttcctgacca
1801 ccttgcacta ttggactttg gaaggaggtg cctatagaaa acgattttga acatacttca
1861 tcgcagtgga ctgtgtccct cggtgcagaa actaccagat ttgagggacg aggtcaagga
1921 gatatgatag gcccggaagt tgctgtgccc catcagcagc ttgacgcgtg gtcacaggac
1981 gatttcactg acactgcgaa ctctcaggac taccggttac caagaggtta ggtgaagtgg
2041 tttaaaccaa acggaactct tcatcttaaa ctacacgttg aaaatcaacc caataattct
2101 gtattaactg aattctgaac ttttcaggag gtactgtgag gaagagcagg caccagcagc
2161 agaatgggga atggagaggt gggcaggggt tccagcttcc ctttgatttt ttgctgcaga
2221 ctcatccttt ttaaatgaga cttgttttcc cctctctttg agtcaagtca aatatgtaga
2281 ttgcctttgg caattcttct tctcaagcac tgacactcat taccgtctgt gattgccatt
2341 tcttcccaag gccagtctga acctgaggtt gctttatcct aaaagtttta acctcaggtt
2401 ccaaattcag taaattttgg aaacagtaca gctatttctc atcaattctc tatcatgttg
2461 aagtcaaatt tggattttcc accaaattct gaatttgtag acatacttgt acgctcactt
2521 gcccccagat gcctcctctg tcctcattct tctctcccac acaagcagtc tttttctaca
2581 gccagtaagg cagctctgtc rtggtagcag atggtcccat tattctaggg tcttactctt
2641 tgtatgatga aaagaatgtg ttatgaatcg gtgctgtcag ccctgctgtc agaccttctt
2701 ccacagcaaa tgagatgtat gcccaaagcg gtagaattaa agaagagtaa aatggctgtt
2761 gaagc
//