LOCUS HUMGGFB 1199 bp mRNA linear HUM 12-JUN-1993 DEFINITION Human recombinant glial growth factor mRNA, complete cds and flanking region. ACCESSION L12261 VERSION L12261.1 KEYWORDS glial growth factor; neuregulin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1199) AUTHORS Marchionni,M.A., Goodearl,A.D.G., Chen,M., Bermingham-McDonogh,O., Kirk,C., Hendricks,M., Danehy,F., Misumi,D., Sudhalter,J., Kobayashi,K., Wroblewski,D., Lynch,C., Baldasarre,M., Hiles,I., Davis,J.B., Hsuan,J., Totty,N.F., Otsu,M., McBurney,R.N., Waterfield,M.D., Stroobant,P. and Gwynne,D. TITLE Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system JOURNAL Nature 362 (6418), 312-318 (1993) PUBMED 8096067 COMMENT Original source text: Homo sapiens fetal brain mRNA. FEATURES Location/Qualifiers source 1..1199 /db_xref="H-InvDB:HIT000192168" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="brain" /dev_stage="fetal" 5'UTR 1..393 CDS 394..1119 /function="Schwann cell mitogen" /standard_name="GGFHFB1" /standard_name="neuregulin" /note="epidermal growth factor (EGF) domain (934..1083); immunoglobulin domain (493..793); expressed in nervous system: spinal cord and brain; same (or homologous) gene produces glial growth factor 2, heregulins, neu differentiation factor and ARIA by alternative splicing" /codon_start=1 /product="recombinant glial growth factor" /protein_id="AAB59358.1" /translation="MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKS QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKA SLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVST EGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG DRCQNYVMASFYSTSTPFLSLPE" variation 506 /note="CGA to CAA variant noted between rhGGF2 and GGFHFB1; and between heregulins alpha and beta(1-3)" /replace="a" 3'UTR 1120..1199 BASE COUNT 308 a 337 c 335 g 219 t ORIGIN 1 gcgcggaggc caggagctga gcggcggcgg ctgccggacg atgggagcgt gagcaggacg 61 gtgataacct ctccccgatc gggttgcgag ggcgccgggc agaggccagg acgcgagccg 121 ccagcggcgg gacccatcga cgacttcccg gggcgacagg agcagccccg agagccaggg 181 cgagcgcccg ttccaggtgg ccggaccgcc cgccgcgtcc gcgccgcgct ccctgcaggc 241 aacgggagac gcccccgcgc agcgcgagcg cctcagcgcg gccgctcgct ctccccatcg 301 agggacaaac ttttcccaaa cccgatccga gcccttggac caaactcgcc tgcgccgaga 361 gccgtccgcg tagagcgctc cgtctccggc gagatgtccg agcgcaaaga aggcagaggc 421 aaagggaagg gcaagaagaa ggagcgaggc tccggcaaga agccggagtc cgcggcgggc 481 agccagagcc cagccttgcc tccccgattg aaagagatga aaagccagga atcggctgca 541 ggttccaaac tagtccttcg gtgtgaaacc agttctgaat actcctctct cagattcaag 601 tggttcaaga atgggaatga attgaatcga aaaaacaaac cacaaaatat caagatacaa 661 aaaaagccag ggaagtcaga acttcgcatt aacaaagcat cactggctga ttctggagag 721 tatatgtgca aagtgatcag caaattagga aatgacagtg cctctgccaa tatcaccatc 781 gtggaatcaa acgagatcat cactggtatg ccagcctcaa ctgaaggagc atatgtgtct 841 tcagagtctc ccattagaat atcagtatcc acagaaggag caaatacttc ttcatctaca 901 tctacatcca ccactgggac aagccatctt gtaaaatgtg cggagaagga gaaaactttc 961 tgtgtgaatg gaggggagtg cttcatggtg aaagaccttt caaacccctc gagatacttg 1021 tgcaagtgcc caaatgagtt tactggtgat cgctgccaaa actacgtaat ggccagcttc 1081 tacagtacgt ccactccctt tctgtctctg cctgaatagg agcatgctca gttggtgctg 1141 ctttcttgtt gctgcatctc ccctcagatt ccacctagag ctagatgtgt cttaccaga //