LOCUS HUMSQAUSYN 1320 bp mRNA linear HUM 13-JAN-1995
DEFINITION Human squalene synthetase (ERG9) mRNA, complete cds.
ACCESSION L06070
VERSION L06070.1
KEYWORDS squalene; squalene synthetase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1320)
AUTHORS Robinson,G.W., Tsay,Y.H., Kienzle,B.K., Smith-Monroy,C.A. and
Bishop,R.W.
TITLE Conservation between human and fungal squalene synthetases:
similarities in structure, function, and regulation
JOURNAL Mol. Cell. Biol. 13 (5), 2706-2717 (1993)
PUBMED 8474436
COMMENT Original source text: Homo sapiens (tissue library: Stratagene
Uni-Zap XR) Male Liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1320
/db_xref="H-InvDB:HIT000191694"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/haplotype="WT"
/sex="male"
/tissue_type="Liver"
/tissue_lib="Stratagene Uni-Zap XR"
gene 1..1320
/gene="ERG9"
5'UTR 1..9
/gene="ERG9"
CDS 10..1263
/gene="ERG9"
/EC_number="2.5.1.21"
/codon_start=1
/product="squalene synthetase"
/protein_id="AAA60582.1"
/translation="MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCY
KYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDK
HVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIR
DYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITY
LSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAV
KAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVML
LAALSWQYLTTLSQVTEDYVQTGEH"
3'UTR 1264..1320
/gene="ERG9"
BASE COUNT 347 a 323 c 326 g 324 t
ORIGIN
1 tgcgccagga tggagttcgt gaaatgcctt ggccaccccg aagagttcta caacctggtg
61 cgcttccgga tcgggggcaa gcggaaggtg atgcccaaga tggaccagga ctcgctcagc
121 agcagcctga aaacttgcta caagtatctc aatcagacca gtcgcagttt cgcagctgtt
181 atccaggcgc tggatgggga aatgcgcaac gcagtgtgca tattttatct ggttctccga
241 gctctggaca cactggaaga tgacatgacc atcagtgtgg aaaagaaggt cccgctgtta
301 cacaactttc actctttcct ttaccaacca gactggcggt tcatggagag caaggagaag
361 gatcgccagg tgctggagga cttcccaacg atctcccttg agtttagaaa tctggctgag
421 aaataccaaa cagtgattgc cgacatttgc cggagaatgg gcattgggat ggcagagttt
481 ttggataagc atgtgacctc tgaacaggag tgggacaagt actgccacta tgttgctggg
541 ctggtcggaa ttggcctttc ccgtcttttc tcagcctcag agtttgaaga ccccttagtt
601 ggtgaagata cagaacgtgc caactctatg ggcctgtttc tgcagaaaac aaacatcatc
661 cgtgactatc tggaagacca gcaaggagga agagagttct ggcctcaaga ggtttggagc
721 aggtatgtta agaagttagg ggattttgct aagccggaga atattgactt ggccgtgcag
781 tgcctgaatg aacttataac caatgcactg caccacatcc cagatgtcat cacctacctt
841 tcgagactca gaaaccagag tgtgtttaac ttctgcgcta ttccacaggt gatggccatt
901 gccactttgg ctgcctgtta taataaccag caggtgttca aaggggcagt gaagattcgg
961 aaagggcaag cagtgaccct gatgatggat gccaccaata tgccagctgt caaagccatc
1021 atatatcagt atatggaaga gatttatcat agaatccccg actcagaccc atcttctagc
1081 aaaacaaggc agatcatctc caccatccgg acgcagaatc ttcccaactg tcagctgatt
1141 tcccgaagcc actactcccc catctacctg tcgtttgtca tgcttttggc tgccctgagc
1201 tggcagtacc tgaccactct ctcccaggta acagaagact atgttcagac tggagaacac
1261 tgatcccaaa tttgtccata gctgaagtcc accataaagt ggatttactt tttttcttta
//