LOCUS HUMOTC 1464 bp mRNA linear HUM 07-JAN-1995 DEFINITION Human ornithine transcarbamylase (OTC) mRNA, complete coding sequence. ACCESSION K02100 VERSION K02100.1 KEYWORDS nuclear matrix protein; ornithine transcarbamylase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1464) AUTHORS Horwich,A.L., Fenton,W.A., Williams,K.R., Kalousek,F., Kraus,J.P., Doolittle,R.F., Konigsberg,W. and Rosenberg,L.E. TITLE Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase JOURNAL Science 224 (4653), 1068-1074 (1984) PUBMED 6372096 COMMENT Original source text: Human cDNA to adult liver mRNA, clones pHO-1, pHO-7, and pHO-31. The structural gene for ornithine transcarbamylase (OTC) is a nuclear-coded polypeptide encoded on the X chromosome. OTC consists of 3 identical subunits. The precursor for each subunit is synthesized in the cytoplasm and then processed posttranslationally to its mature form during mitochondrial import. Comparison of the human mature OTC subunit sequence with that of the rat revealed 90% amino acid homology, and 95% DNA sequence homology. The cDNA sequence of OTC was derived from three overlapping sequences from plasmids pHO-1, pHO-7, and pHO-31. FEATURES Location/Qualifiers source 1..1464 /db_xref="H-InvDB:HIT000191380" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="Xp21.1" /tissue_type="liver" /dev_stage="adult" gene 1..1464 /gene="OTC" mRNA <1..>1464 /gene="OTC" /product="OTC mRNA" CDS 136..1200 /gene="OTC" /codon_start=1 /product="ornithine transcarbamylase" /protein_id="AAA59975.1" /db_xref="GDB:G00-119-468" /translation="MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLT LKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFA LLGGHPCFPTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPII NGLSDLYHPIQILADYLTLQEHYSSLKGLTLSCFGDGNNILHSIMMSAAKFGMHLQAA TPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGREEEKKK RLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTI MAVMVSLLTDYSPQLQKPKF" sig_peptide 136..231 /gene="OTC" /note="G00-119-468" mat_peptide 232..1197 /gene="OTC" /product="ornithine transcarbamylase" /note="G00-119-468" BASE COUNT 445 a 297 c 323 g 399 t ORIGIN 243 bp upstream of PvuII site on X chromosome. 1 aagctgaagg gtgatattac ctttgctccc tcactgcaac tgaacacatt tcttagtttt 61 taggtggccc ccgctggcta acttgctgtg gagttttcaa gggcatagaa tcgtccttta 121 cacaattaaa agaagatgct gtttaatctg aggatcctgt taaacaatgc agcttttaga 181 aatggtcaca acttcatggt tcgaaatttt cggtgtggac aaccactaca aaataaagtg 241 cagctgaagg gccgtgacct tctcactcta aaaaacttta ccggagaaga aattaaatat 301 atgctatggc tatcagcaga tctgaaattt aggataaaac agaaaggaga gtatttgcct 361 ttattgcagg ggaagtcctt aggcatgatt tttgagaaaa gaagtactcg aacaagattg 421 tctacagaaa caggctttgc acttctggga ggacatcctt gttttcctac cacacaagat 481 attcatttgg gtgtgaatga aagtctcacg gacacggccc gtgtattgtc tagcatggca 541 gatgcagtat tggctcgagt gtataaacaa tcagatttgg acacccttgc taaagaagca 601 tccatcccaa ttatcaatgg gctgtcagat ttgtaccatc ctatccagat cctggctgat 661 tacctcacgc tccaggaaca ctatagctct ctgaaaggtc ttaccctcag ctgtttcggg 721 gatgggaaca atatcctgca ctccatcatg atgagcgcag cgaaattcgg aatgcacctt 781 caggcagcta ctccaaaggg ttatgagccg gatgctagtg taaccaagtt ggcagagcag 841 tatgccaaag agaatggtac caagctgttg ctgacaaatg atccattgga agcagcgcat 901 ggaggcaatg tattaattac agacacttgg ataagcatgg gacgagaaga ggagaagaaa 961 aagcggctcc aagctttcca aggttaccaa gttacaatga agactgctaa agttgctgcc 1021 tctgactgga catttttaca ctgcttgccc agaaagccag aagaagtgga tgatgaagtc 1081 ttttattctc ctcgatcact agtgttccca gaggcagaaa acagaaagtg gacaatcatg 1141 gctgtcatgg tgtccctgct gacagattac tcacctcagc tccagaagcc taaattttga 1201 tgttgtgtta cttgtcaaga aagaagcaat gttggtcagt aacagaatga gttggtttat 1261 ggggaaaaga gaagagaatc taaaaaataa accaatccct aacacgtggt atgggcgaat 1321 cgtacgatat gctttgccat tgtgaaactt tccttaagcc ttcaatttaa gtgctgatgc 1381 actgtaatac gtgcttaact ttgcttaaac tctctaattc ccaatttctg agttacattt 1441 agatatcata ttaactatca tata //