LOCUS EU921893 1789 bp mRNA linear HUM 27-AUG-2008 DEFINITION Homo sapiens uridine monophosphate synthetase isoform H (UMPS) mRNA, complete cds. ACCESSION EU921893 VERSION EU921893.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1789) AUTHORS Griffith,M., Pugh,T.J., Tang,M.J., Asano,J.K., Ally,A., Chan,S.Y., Taylor,G., Morin,G.B., Tai,I.T. and Marra,M.A. TITLE Genomic analysis of UMPS expression and sequence reveals novel isoforms and sequence polymorphisms associated with 5-FU resistance JOURNAL Unpublished REFERENCE 2 (bases 1 to 1789) AUTHORS Griffith,M., Pugh,T.J., Tang,M.J., Asano,J.K., Ally,A., Chan,S.Y., Taylor,G., Morin,G.B., Tai,I.T. and Marra,M.A. TITLE Direct Submission JOURNAL Submitted (24-JUL-2008) Genome Sciences Centre, British Columbia Cancer Agency, BC Cancer Research Centre, 675 West 10th Avenue, 7th Floor, Vancouver, BC V5Z 1L3, Canada COMMENT Created by TOPO TA cloning. Direction is forward with respect to M13F site. PCR primers used to generate clone were 5'-CAAACAGGCAGCGCGCGACA-3' (forward) and 5'-GCTGACTTTAGCCTCTTGGTGCCC-3' (reverse). FEATURES Location/Qualifiers source 1..1789 /db_xref="H-InvDB:HIT000558357" /organism="Homo sapiens" /mol_type="mRNA" /isolation_source="colorectal cancer cell line" /db_xref="taxon:9606" /clone="RKO_1800_5" /cell_line="RKO" /PCR_primers="fwd_seq: caaacaggcagcgcgcgaca, rev_seq: gctgactttagcctcttggtgccc" gene 1..1789 /gene="UMPS" /gene_synonym="OPRT" CDS 208..1116 /gene="UMPS" /gene_synonym="OPRT" /codon_start=1 /product="uridine monophosphate synthetase isoform H" /protein_id="ACH48231.1" /translation="MQASVLTPCVECLIQLCHWLQLSVQPIKFQCLLEGKKQRIMEAP KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICML KTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWAD LVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEF VVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGII SAADRLEAAEMYRKAAWEAYLSRLGV" BASE COUNT 447 a 387 c 448 g 507 t ORIGIN 1 caaacaggca gcgcgcgaca atggcggtcg ctcgtgcagc tttggggcca ttggtgacgg 61 gtctgtacga cgtgcaggct ttcaagtttg gggacttcgt gctgaagagc gggctttcct 121 cccccatcta catcgatctg cggggcatcg tgtctcgacc gcgtcttctg agtcaggttg 181 cagatatttt attccaaact gcccaaaatg caggcatcag ttttgacacc gtgtgtggag 241 tgccttatac agctttgcca ttggctacag ttatctgttc aaccaatcaa attccaatgc 301 ttattagaag gaaagaaaca aaggattatg gaagcaccca aagaactcag cttcggtgca 361 cgtgcagagc tgcccaggat ccacccagtt gcatcgaagc ttctcaggct tatgcaaaag 421 aaggagacca atctgtgtct atctgctgat gtttcactgg ccagagagct gttgcagcta 481 gcagatgctt taggacctag tatctgcatg ctgaagactc atgtagatat tttgaatgat 541 tttactctgg atgtgatgaa ggagttgata actctggcaa aatgccatga gttcttgata 601 tttgaagacc ggaagtttgc agatatagga aacacagtga aaaagcagta tgaaggaggt 661 atctttaaaa tagcttcctg ggcagatcta gtaaatgctc acgtggtgcc aggctcagga 721 gttgtgaaag gcctgcaaga agtgggcctg cctttgcatc gggggtgcct ccttattgcg 781 gaaatgagct ccaccggctc cctggccact ggggactaca ctagagcagc ggttagaatg 841 gctgaggagc actctgaatt tgttgttggt tttatttctg gctcccgagt aagcatgaaa 901 ccagaatttc ttcacttgac tccaggagtt cagttggaag caggaggaga taatcttggc 961 caacagtaca atagcccaca agaagttatt ggtaaacgag gttccgatat catcattgta 1021 ggtcgtggca taatctcagc agctgatcgt ctggaagcag cagagatgta cagaaaagct 1081 gcttgggaag cgtatttgag tagacttggt gtttgagtgc ttcagataca tttttcagat 1141 acaatgtgaa gacattgaag atatgtggtc ctcctgaaag tcactggctg gaaataatcc 1201 aattattcct gcttggattc ttccacaggg cctgtgtaag aatgggttct ggagttctca 1261 tggtctttag gaaatattga gtaatttgta atcaccgcat tgatactata ataagttcat 1321 tcttaagctt gctttttttg agactggtgt ttgttagaca gccacagtcc tgtctgggtt 1381 agggtcttcc acatttgagg atccttccta tctctccatg ggactagact gctttgttat 1441 tctatttatt ttttaatttt tttcgagaca ggatctcact ctgttgccca ggatggagtg 1501 cagtggtgag atcacggctc attgcagcct cgacctccca ggtgatcctc ccacctcagc 1561 ttccagatta gctggtgcta taggcatgca ccaccacgtc catctaaatt tctttattat 1621 ttgtagagat gaggtcttgc catgttaccc aggctggtct caactcctgg gctcaagcga 1681 tcctcctgcc tcagtctctc aaagtgctgg gattacaggt gtgagccact gtgcccagcc 1741 taattgcagt aagacaaaaa ttctagggca ccaagaggct aaagtcagc //