LOCUS BC136421 3623 bp mRNA linear HUM 12-MAY-2008
DEFINITION Homo sapiens intestinal cell (MAK-like) kinase, mRNA (cDNA clone
MGC:168032 IMAGE:9020409), complete cds.
ACCESSION BC136421
VERSION BC136421.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3623)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3623)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: LLDM Plate: 670 Row: h Column: 7.
FEATURES Location/Qualifiers
source 1..3623
/db_xref="H-InvDB:HIT000500443"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:168032 IMAGE:9020409"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_362"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: AGTGACAG"
gene 1..3623
/gene="ICK"
/gene_synonym="LCK2"
/gene_synonym="MRK"
/db_xref="GeneID:22858"
/db_xref="HGNC:HGNC:21219"
CDS 41..1939
/gene="ICK"
/gene_synonym="LCK2"
/gene_synonym="MRK"
/codon_start=1
/product="intestinal cell (MAK-like) kinase"
/protein_id="AAI36422.1"
/db_xref="GeneID:22858"
/db_xref="HGNC:HGNC:21219"
/translation="MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE
CMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
RNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYV
STRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT
PKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTAS
QALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRIS
SRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEH
KNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFE
SVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSN
PGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGS
AMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDW
ASKYASRR"
BASE COUNT 1050 a 829 c 748 g 996 t
ORIGIN
1 ttcggccgtg agatgagtgt ccggcctgag caggcacacc atgaatagat acacaacaat
61 caggcagctc ggggatggaa cctacggttc cgtcctgctg ggaagaagca ttgagtctgg
121 ggagctgatc gctattaaaa aaatgaaaag aaaattttat tcctgggagg aatgcatgaa
181 ccttcgggag gttaagtctt taaagaagct caaccatgcc aatgtagtca aattaaaaga
241 agttatcagg gaaaatgatc atctttattt tatcttcgag tacatgaagg aaaatcttta
301 ccagctcatt aaagagagaa ataagttgtt tcctgagtct gctataagga atatcatgta
361 tcagatatta caaggactcg catttattca caaacacggc ttctttcatc gagacttaaa
421 gcctgagaac ctcctctgca tgggaccaga acttgtgaaa attgcagact ttggtttggc
481 ccgagaaata cgatcaaaac ctccatatac agattatgta tctaccagat ggtacagggc
541 tccagaagta ctcctgaggt ctaccaacta cagctccccc attgacgtct gggcggtggg
601 ctgcatcatg gcagaagttt acaccctcag gccactcttc cctggagcca gtgaaattga
661 cacaatattc aaaatttgcc aagtgctggg gacaccaaaa aagactgact ggcctgaagg
721 ctatcaactt tcaagtgcaa tgaacttccg ttggccacag tgtgtaccca ataacttaaa
781 gaccttgatt cccaatgcta gcagtgaagc agtccagctc ctgagagaca tgcttcagtg
841 ggatcccaag aaacgaccaa cagctagtca ggcacttcga tatccttact tccaagttgg
901 acacccacta ggcagcacca cacaaaacct tcaggattca gaaaaaccac agaaaggcat
961 cctggaaaag gcaggcccac ctccttatat taagccagtc ccacctgccc agccaccagc
1021 caagccacac acacgaattt cttcacgaca gcatcaagcc agccagcccc ctctgcatct
1081 cacgtacccc tacaaagcag aggtctccag gacagatcac ccaagccatc tccaggagga
1141 caagccaagc ccgttgcttt tcccatccct ccacaacaag catccacagt cgaaaatcac
1201 agctggcctg gagcacaaaa atggtgagat aaagccaaag agtaggagaa ggtggggtct
1261 tatttccagg tcaacaaagg attcagatga ttgggctgac ttggatgact tggatttcag
1321 tccatccctc agcaggattg acctgaaaaa caagaaaaga cagagtgatg acactctctg
1381 caggtttgag agtgttttgg acctgaagcc ctctgagcct gtgggcacag gaaacagtgc
1441 ccccacccag acgtcatatc agcggcgaga cacgcccacc ctgagatctg cagccaagca
1501 gcactatttg aagcactctc gatacttgcc tgggatcagt ataagaaatg gcatactctc
1561 gaatccaggc aaggaattta ttccacctaa tccatggtct agttctggct tgtctggaaa
1621 atcttcaggg acaatgtcag taatcagcaa agtaaattca gttggttcca gctctacaag
1681 ttctagtgga ctgactggaa actatgtccc ttcctttctg aaaaaagaaa tcggttctgc
1741 tatgcagagg gtacacctag cacctattcc agacccttcc cctggttatt cctccctgaa
1801 ggccatgaga cctcatcctg ggcgaccatt cttccacacc cagcctagaa gcactcctgg
1861 gttgatacca cggcctccag ccgcccagcc agtgcatggc cggacagact gggcttccaa
1921 gtacgcatct cggcgatgac tgtctgcctt ggtgatgaat ctcttcctag ggagaagcag
1981 gatactttcc ctcagctgac tggtgttcta cctgcaagat gtgcagaggg cataaaagca
2041 aatcaacact ttatagttat tcttctgaac taagacatgt caatattctt ttttaaagtt
2101 tttttttaaa atattgattt gaatgcagta ggcttttttg tataaaatta ttttattcta
2161 aaactgggtc ccattatttt cttaaacaac agcattttgt atatatggat tatgttttag
2221 cattttatac agtcaacttt gtaatgaact ttttaaaaat taattgattt tcctttgggg
2281 ttccagataa tattttctac agattttgaa aaatgtaata atattaatgc agtattgcaa
2341 caggggtgca atttaaggct atgtgataga gggttattta ctcagtgtgt gcagatattt
2401 atgaagtggt gaaatttcaa gtgtggctca ctaggtactt caggccttct tggactgttg
2461 ttagaaaagt gatcctctgc ttttcttagt aggtcattgg tttgattttt ggataccact
2521 ctgctgttct aaaaggacta ttatattata taattcactt tgttttactt ttgttcccca
2581 gatgaaagaa ctctaagtaa atacatttta aaaaattttt ctgacaccct ttaatgtggt
2641 tgcagatctc agatgaaacc aagcttaatt atactatgcc attatattct aatttattcc
2701 atttttgaaa tcaagttgta tgtgtaccaa taaaagagat ttctgcttca aaaggctctc
2761 aacatgaagg ttaacacagt caatcaaact tacattcctg ccaagatgca tggccaaaaa
2821 actaagtatc aaagcagcag aaggtttttg attatagtaa ctgagatgga attttgtgcc
2881 tagctcagtt ctccagatct ggctaggagc agtcaatgac taatgttctg tcctagccaa
2941 attctcagga caatttgggg agcagaaaga gttatggcag aggttccact catctacaaa
3001 gtcacagtca catgccacat ttgatctcct aaccctggtg tagtttcttt caagagtgag
3061 aactttattt gttgggcaga ggctgttcca ttgagaggaa tgtttacagc agtttcaaaa
3121 atgacaaagt cagtttggag acagaaaaag acaaaaggtc cagtctcatc catctctata
3181 tggtacattt gcctcactta tggttgcctt aaaggcaaga gggaaggtca ccatcagtga
3241 acgcaatgca atctcaacag tgtattgatt catattctcc tagggctcaa actactctct
3301 attggttcca ggataatgac aaattgaacc atatgtaagt aatcttttat tttttatttt
3361 ttttttgaga cagagtctca ctctgtcacc caggctggag tgcagtggcg cgatcttagc
3421 tctctgcaac ctctgcctcc caggttcaag cctcctgagt aactgggact acaggcgccc
3481 gccaccacgc ccagctaatt ttttgtattt ttagtagaga cggggtttca ctgtgttagc
3541 caggacggcc tcgatctcct gacctcgtga tccaccctcc tccacctccc aaagtactgg
3601 gattacaggc atgagccact gca
//