LOCUS BC095408 3743 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens cathepsin B, mRNA (cDNA clone MGC:110901
IMAGE:30334082), complete cds.
ACCESSION BC095408
VERSION BC095408.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3743)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3743)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (06-MAY-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Stefan Hansson
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 198 Row: g Column: 5
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 66346646.
FEATURES Location/Qualifiers
source 1..3743
/db_xref="H-InvDB:HIT000335201"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:110901 IMAGE:30334082"
/tissue_type="Placenta, pre-eclamptic"
/clone_lib="NIH_MGC_148"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..3743
/gene="CTSB"
/gene_synonym="APPS"
/gene_synonym="CPSB"
/db_xref="GeneID:1508"
/db_xref="HGNC:HGNC:2527"
/db_xref="MIM:116810"
CDS 113..1132
/gene="CTSB"
/gene_synonym="APPS"
/gene_synonym="CPSB"
/codon_start=1
/product="cathepsin B"
/protein_id="AAH95408.1"
/db_xref="GeneID:1508"
/db_xref="HGNC:HGNC:2527"
/db_xref="MIM:116810"
/translation="MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAG
HNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQ
GSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWN
FWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPT
YKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMG
GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQ
YWEKI"
BASE COUNT 919 a 981 c 967 g 876 t
ORIGIN
1 ggctgcaggg ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg
61 gctgcaggct ctcggctgca gcgctgggtg gatctaggat ccggcttcca acatgtggca
121 gctctgggcc tccctctgct gcctgctggt gttggccaat gcccggagca ggccctcttt
181 ccatcccctg tcggatgagc tggtcaacta tgtcaacaaa cggaatacca cgtggcaggc
241 cgggcacaac ttctacaacg tggacatgag ctacttgaag aggctatgtg gtaccttcct
301 gggtgggccc aagccacccc agagagttat gtttaccgag gacctgaagc tgcctgcaag
361 cttcgatgca cgggaacaat ggccacagtg tcccaccatc aaagagatca gagaccaggg
421 ctcctgtggc tcctgctggg ccttcggggc tgtggaagcc atctctgacc ggatctgcat
481 ccacaccaat gcgcacgtca gcgtggaggt gtcggcggag gacctgctca catgctgtgg
541 cagcatgtgt ggggacggct gtaatggtgg ctatcctgct gaagcttgga acttctggac
601 aagaaaaggc ctggtttctg gtggcctcta tgaatcccat gtagggtgca gaccgtactc
661 catccctccc tgtgagcacc acgtcaacgg ctcccggccc ccatgcacgg gggagggaga
721 tacccccaag tgtagcaaga tctgtgagcc tggctacagc ccgacctaca aacaggacaa
781 gcactacgga tacaattcct acagcgtctc caatagcgag aaggacatca tggccgagat
841 ctacaaaaac ggccccgtgg agggagcttt ctctgtgtat tcggacttcc tgctctacaa
901 gtcaggagtg taccaacacg tcaccggaga gatgatgggt ggccatgcca tccgcatcct
961 gggctgggga gtggagaatg gcacacccta ctggctggtt gccaactcct ggaacactga
1021 ctggggtgac aatggcttct ttaaaatact cagaggacag gatcactgtg gaatcgaatc
1081 agaagtggtg gctggaattc cacgcaccga tcagtactgg gaaaagatct aatctgccgt
1141 gggcctgtcg tgccagtcct gggggcgaga tcggggtaga aatgcatttt attctttaag
1201 ttcacgtaag atacaagttt caggcagggt ctgaaggact ggattggcca aacatcagac
1261 ctgtcttcca aggagaccaa gtcctggcta catcccagcc tgtggttaca gtgcagacag
1321 gccatgtgag ccaccgctgc cagcacagag cgtccttccc cctgtagact agtgccgtag
1381 ggagtacctg ctgccccagc tgactgtggc cccctccgtg atccatccat ctccagggag
1441 caagacagag acgcaggaat gggaagcgga gttcctaaca ggatgaaagt tcccccatca
1501 gttcccccag tacctccaag caagtagctt tccacatttg tcacagaaat cagaggagag
1561 atggtgttgg gagccctttg gagaacgcca gtctcccagg ccccctgcat ctatcgagtt
1621 tgcaatgtca caacctctct gatgttgtgc tcagcatgat tctttaatag aagttttatt
1681 ttttcgtgca ctctgctaat catgtgggtg agccagtgga acagcgggag acctgtgcta
1741 gttttacaga ttgcctccta atgacgcggc tcaaaaggaa accaagtggt caggagttgt
1801 ttctgaccca ctgatctcta ctaccacaag gaaaatagtt taggagaaac cagcttttac
1861 tgtttttgaa aaattacagc ttcaccctgt caagttaaca aggaatgcct gtgccaataa
1921 aaggtttctc caacttgaag tctactctga tgggatctca gatcctttgt cactgcctat
1981 agacttgtag ctgctgtctc tctttgtccc tgcagagaat cacgtcctgg aactgcatgt
2041 tcttgcgact cttgggactt catcttaact tctcgctgcc ccagccatgt tttcaaccat
2101 ggcatccctc ccccaattag ttccctgtca tcctcgtcaa ccttcactgt aagtgcctgg
2161 taagcttgcc cttgcttaag aactcaaaac atagctgtgc tctatttttt tgttgttgtt
2221 gtgactgaca gagtgagatt ccgtctccca ggctggagtg cagtggcgcc ttctcggctc
2281 actgcaacct gcagcctcct agattcaagc gattctcctg cttcagcctt ccgagtagct
2341 gggatgacag gcactcacca atatgcctgg gtagtttttg tgtttttaag tacatacagg
2401 atttcaccat gttggccagg ctagtttcga actcctggcc tcaggtggtc tgcctgcctc
2461 ggcctcccaa ggtgttggga ttacaggcgt gagccactgg gccctgcctg tattttttat
2521 cagccacaaa tccagcaaca agctgaggat tcagctcata aaacaggctt ggtgtcttgg
2581 tgatctcaca taaccaagat gctaccccgt ggggaaccac atccccctgg atgccctcca
2641 gccttggttt gggctggagt cagggcctgg atacagtatt ttgaatttgt atgccactgg
2701 tttgcattgc tggtcaggaa ctctagtgct ttgcatagcc ctggtttaga aacatgttat
2761 agcagttctt ggtatagagc aaactagaag aaccagcaat cattccactg tcctgccaag
2821 gtacacctca gtactcccct tcccaactga agtggtatga ggctagctct ttccaaaagc
2881 attcaagttt ggcttctgat gtgactcaga atttaggaac cagatgctag atcaaataag
2941 ctctgaaaat ctgaggaaca ttgtaggaaa ggtttgttaa gcatctctta agtgccatga
3001 tgagcataac agccggccgt ggtggctcac gcctgtaagc ccagcacttt gggaggccga
3061 ggtgggaaga tgacaaggtc aggagttcgg gaccagcctg gccaacatgc tgaaacctca
3121 cctctactga agatacaaga attggctggg catggtggca catgcctgtg atcccagcta
3181 cttgggaggc tgaggcagga gaatcgcttg agcccgggag gcggaggttg cagtgagccg
3241 agacagtgcc agtgcactcc agcctcggtg acagcgcaag gctccgtctc aataattaaa
3301 aaaaaaaaaa aaaaagaggc cgggcgcagt ggctcaagcc tgtaatccca gcactttggg
3361 aggctgaggc gggcagatca cctgaggtca ggagttttga gatcagcctt ggcaacacgg
3421 tgaaacccca tctctactaa aaatacaaaa ttagccaagc atgctggcac atgcctgtaa
3481 tcccagctac tcgtgaggct gaggtacgag aatcgcttga acctgggagg cagaggatgc
3541 agtgagccga gatcacgcca ttgcactcca gcctggggga caagagtgaa tctgtgtctc
3601 accaaaaaaa aaaagaaaaa gaaagatgct taacaaaggt taccataagc cacaaattca
3661 tgaccactta tccttccagt ttcaagtaga atatattcat aacctcaata aagttctccc
3721 tgctcccaaa aaaaaaaaaa aaa
//