LOCUS BC063519 2860 bp mRNA linear HUM 19-APR-2005
DEFINITION Homo sapiens PH domain and leucine rich repeat protein phosphatase,
mRNA (cDNA clone IMAGE:4341956), partial cds.
ACCESSION BC063519
VERSION BC063519.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2860)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2860)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Lou Staudt
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 134 Row: e Column: 11.
FEATURES Location/Qualifiers
source 1..2860
/db_xref="H-InvDB:HIT000260977"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4341956"
/tissue_type="Lymph, lymphoma"
/clone_lib="NIH_MGC_85"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..2860
/gene="PHLPP"
/gene_synonym="PLEKHE1"
/gene_synonym="SCOP"
/db_xref="GeneID:23239"
CDS <1..1844
/gene="PHLPP"
/gene_synonym="PLEKHE1"
/gene_synonym="SCOP"
/codon_start=3
/product="PHLPP protein"
/protein_id="AAH63519.1"
/db_xref="GeneID:23239"
/translation="LPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKT
LELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREAL
YGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGG
AAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQ
HKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDS
LSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAG
GAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTAS
DEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPI
EGVFTNGSRVEVEVDIHCSRAKEKEKQHLLQVPAEASDEGIVISANEDEPGLPRKADF
SAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPEL
EEEVKEIMKHHQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL"
BASE COUNT 714 a 748 c 707 g 691 t
ORIGIN
1 agctcccaga gatcaagtgt gtggacctga gctgtaatga gctaagtgaa gtcacattac
61 cagaaaacct gcctcccaaa ctgcaggagc tagacctgac tggaaacccg cgccttgtcc
121 ttgatcacaa aaccctggaa ctactgaata atatccgctg tttcaagatt gatcagcctt
181 ctacaggaga cgcttccgga gccccagctg tatggagtca tggttacact gaagcttcgg
241 gggtaaaaaa caagttgtgt gtcgcagccc tgtcggtgaa taacttctgt gacaaccgcg
301 aagccctgta tggtgtgttt gacggagacc ggaatgtgga ggtgccctac cttctccagt
361 gcactatgag tgacattttg gctgaagagc tgcaaaaaac aaaaaacgaa gaagaataca
421 tggtcaatac attcattgtc atgcaaagga aacttggaac tgctgggcag aagcttggtg
481 gtgccgctgt cctttgtcat atcaagcatg accctgtgga tccaggagga tccttcacct
541 tgacctctgc taatgtgggc aagtgccaaa cagttctctg tcgaaatgga aagccgctgc
601 ctctgtccag atcttacatc atgagctgtg aagaagagct gaagaggatt aaacagcaca
661 aggccattat cactgaggat ggcaaggtga acggagtgac tgagtccacg cgcatcctgg
721 gctacacctt cctccatccc agtgtggtgc ctcgccccca cgtgcagtcc gtgctcctga
781 ctccccagga tgagttcttc atcctaggca gtaaggggtt gtgggacagc ctgtccgtcg
841 aggaggccgt ggaagccgtg cgcaacgtgc ccgatgccct ggctgctgcc aagaagctgt
901 gtaccctggc ccagagctac ggctgccacg acagcatcag cgctgtggtg gtgcagctca
961 gtgtcactga ggacagcttc tgctgctgcg agctcagcgc cggtggggct gtgccaccac
1021 ccagtcctgg catctttcct ccctcagtga acatggtgat caaggatcgg ccctcagatg
1081 ggctgggcgt gccgtcctcc agcagcggca tggcttccga gattagcagt gagctctcca
1141 cttctgagat gagcagcgag gtggggtcaa cagcctccga tgagcccccg cccggagccc
1201 taagcgagaa cagccctgcc taccccagtg agcagcgctg catgctccac cccatctgtc
1261 tgtccaactc cttccagcgc cagctatcca gcgccacgtt ctctagcgcc ttctccgaca
1321 acggccttga cagtgacgat gaggagccca tcgagggcgt cttcaccaac ggcagccggg
1381 tggaggtgga ggtggacatc cactgcagcc gggccaagga gaaggagaaa cagcacctgc
1441 ttcaggtgcc agcagaggcc agtgatgagg gcattgtcat cagcgccaac gaggatgagc
1501 caggtctgcc caggaaggca gacttctctg ccgttgggac cattgggcgc cggagggcca
1561 atggctctgt tgcgccccag gaaaggagcc acaatgtgat agaggtggct acagacgcac
1621 ctcttcgaaa gcctggaggc tattttgctg ccccggctca gccggatcct gatgatcagt
1681 ttatcatacc cccggagctg gaagaggagg tcaaagaaat catgaagcat caccaggagc
1741 aacagcagca gcagcagccg ccaccacccc ctcagctcca gccgcagctg ccgcggcact
1801 accagctgga ccagctgcca gattattacg acacgccact atgacccagc cgagctgttt
1861 aacaaataaa ctaaccacaa aagactgagt tgcaagagtc tcccaggctc acattaaacc
1921 aggggtttta ctccacatcc ttcccccaga cactgttccc aacctgtcat cgcagctaat
1981 ctgtaggttc tctttctttg ggttattttt ttaagtaatc accactttct tctagtgatg
2041 ctttaccaat atgatttaca tttgttaact tctcccccta acatatcaga tatgtaaaga
2101 caaagaacaa aaggtttaat atattacaga gaaacagtta atgataatgt aatatttttt
2161 aaaatggctt tttgttgttt gtttggaagg cagggcaggc tgccgttgct aaatgattta
2221 ataatattgt aattctgtat ttctttgggg ggaaaaggct tttgttttgt tttgttttgt
2281 tttgttttgt ttttgtcttg aaaataatag acatttgtag aatatggaga ctaactccta
2341 ggagttgctt tactctgtca ggtgacttaa gtcactggga ttcactaatt ttctctgaga
2401 gaacagctga ttgagaattt ccattgtaaa tagctcagtg ttgtatagtg aggcttacga
2461 tgttttgtag tcttggcgta aggacacagc ccaagtaact gacgtttccc ctccccctcc
2521 cctctgagga gcctgcctgc ctcacaactc accctcactt cactgaatga ggaggctgag
2581 cagctgcagt gtttctgtcc ggaggaaatg gatcttaggc cactggacaa gaacctgcac
2641 ccaagggccc tgaacccatt ttcctcccct gtcccagcct tcccactttg acagacactt
2701 ttaactgtgt tccttactgc tgccacaatc agcatggttg tatagtgccc cattaggcca
2761 tttacatacc cagagttata ctcaagcaga atgcacaaat ggacatgtca taatttttgt
2821 tacaataaat atgaaattta caagtaaaaa aaaaaaaaaa
//