LOCUS BC063044 2603 bp mRNA linear HUM 23-DEC-2003 DEFINITION Homo sapiens NIMA (never in mitosis gene a)-related kinase 4, mRNA (cDNA clone MGC:65120 IMAGE:5169184), complete cds. ACCESSION BC063044 VERSION BC063044.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2603) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2603) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (02-DEC-2003) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Genome Sequence Centre, BC Cancer Agency, Vancouver, BC, Canada info@bcgsc.bc.ca Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield, Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott, Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy, George Yang, Scott Zuyderduyn, Marco Marra. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 119 Row: c Column: 18 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 4507276. FEATURES Location/Qualifiers source 1..2603 /db_xref="H-InvDB:HIT000260751" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:65120 IMAGE:5169184" /tissue_type="Brain, adult medulla" /clone_lib="NIH_MGC_119" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..2603 /gene="NEK4" /gene_synonym="NRK2" /gene_synonym="STK2" /db_xref="GeneID:6787" /db_xref="MIM:601959" CDS 194..2539 /gene="NEK4" /gene_synonym="NRK2" /gene_synonym="STK2" /codon_start=1 /product="NEK4 protein" /protein_id="AAH63044.1" /db_xref="GeneID:6787" /db_xref="MIM:601959" /translation="MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASS RERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQL LPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHC DMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRI IEGKLPAMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKT SKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRA SGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLD ASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKE QKPKDQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVR RDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRP LSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQER KQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVP VANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDV IRGLGVQLLEQVYDLLEEEDEFDREVSVSLTVSRCLCYRIF" misc_feature 209..976 /gene="NEK4" /gene_synonym="NRK2" /gene_synonym="STK2" /note="S_TKc; Region: Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation segment of the catalytic domain, sometimes combined with reversible conformational changes in the C-terminal autoregulatory tail" /db_xref="CDD:cd00180" BASE COUNT 782 a 601 c 649 g 571 t ORIGIN 1 gaactgctcc cggcccggat cgctatggca gcggcgtcgt cgcgggccgg gccccagcaa 61 tcccgcccgg gcccggctgc ctcaacagcc gcccccactg ccccctctcg ggcatgaacc 121 gagcttcttg ttgccgcccg ctgccctacc cgccgctgcc gccgcatccc gactctgggc 181 cagcgctggg aacatgcccc tggccgccta ctgctacctg cgggtcgtgg gcaaggggag 241 ctatggagag gtgacgcttg tgaagcaccg gcgggacggc aagcagtatg tcatcaaaaa 301 actgaacctc cgaaatgcct ctagccgaga gcggcgagct gctgaacagg aagcccagct 361 cttgtctcag ttgaagcatc ccaacattgt cacctacaag gagtcatggg aaggaggaga 421 tggtctgctc tacattgtca tgggcttctg tgaaggaggt gatttgtacc gaaagctcaa 481 ggagcagaaa gggcagcttc tgccggagaa tcaggtggta gagtggtttg tacagatcgc 541 catggctttg cagtatttac atgaaaaaca catccttcat cgagatctga aaactcaaaa 601 tgtcttccta acaagaacaa acatcatcaa agtaggggac ctaggaattg cccgagtgtt 661 ggagaaccac tgtgacatgg ctagcaccct cattggcaca ccctactaca tgagccctga 721 attgttctca aacaaaccct acaactataa gtctgatgtt tgggctctag gatgctgtgt 781 ctatgaaatg gccaccttga agcatgcttt caatgcaaaa gatatgaatt ctttagttta 841 tcggattatt gaaggaaagc tgccagcaat gccaagagat tacagcccag agctggcaga 901 actgataaga acaatgctga gcaaaaggcc tgaagaaagg ccgtctgtga ggagcatcct 961 gaggcagcct tatataaagc ggcaaatctc cttctttttg gaggccacaa agataaaaac 1021 ctccaaaaat aacattaaaa atggtgactc tcaatccaag ccttttgcta cagtggtttc 1081 tggagaggca gaatcaaatc atgaagtaat ccacccccaa ccactctctt ctgagggctc 1141 ccagacatat ataatgggtg aaggcaaatg tttgtcccag gagaaaccca gggcctctgg 1201 tctcttgaag tcacctgcca gtctgaaagc ccatacctgc aaacaggact tgagcaatac 1261 cacagaacta gccacaatca gtagcgtaaa tattgacatc ttacctgcaa aagggaggga 1321 ttcagtgagt gatggctttg ttcaggagaa tcagccaaga tatttggatg cctctaatga 1381 gttaggaggt atatgcagta tttctcaagt ggaagaggag atgctgcagg acaacactaa 1441 atccagtgcc cagcctgaaa acctgattcc catgtggtcc tctgacattg tcactgggga 1501 aaagaatgaa ccagtgaagc ctctgcagcc cctaatcaaa gaacaaaagc caaaggacca 1561 ggatcaagtt gctggtgaat gtattataga aaaacagggc agaatccacc cagatttaca 1621 gccacacaac tctgggtctg aaccttccct gtctcgacag cgacggcaaa agaggagaga 1681 acagactgag cacagagggg aaaagagaca ggtccgcaga gatctctttg ctttccaaga 1741 gtcgcctcct cgatttttgc cttctcatcc cattgttggg aaagtggatg tcacatcaac 1801 acaaaaagag gctgaaaacc aacgtagagt ggtcactggg tctgtgagca gttcaaggag 1861 cagtgagatg tcatcatcaa aggatcgacc attatcagcc agagagagga ggcgactaaa 1921 gcagtcacag gaagaaatgt cctcttcagg cccttcagtg aggaaagcgt ctctgagtgt 1981 agcagggcca ggaaaacccc aggaagaaga ccagcccttg cctgcccgac ggctctcctc 2041 tgactgcagc gtcactcagg aaaggaaaca gattcattgt ctgtctgagg atgagttaag 2101 ttcttctaca agttcaactg ataagtcaga tggggattac ggggaaggga aaggtcagac 2161 aaatgaaatt aatgccttgg tacaattgat gactcagacc ctgaaactgg attctaaaga 2221 gagctgtgaa gatgtcccgg tagcaaaccc agtgtcagaa ttcaaacttc atcggaaata 2281 tcgggacaca ctgatacttc atgggaaggt tgcagaagag gcagaggaaa tccattttaa 2341 agagctacct tcagctatta tgccaggttc tgaaaagatc aggagactag ttgaagtctt 2401 gagaactgat gtaattcgtg gcctgggagt tcagctttta gagcaggtgt atgatctttt 2461 ggaggaggag gatgaatttg atagagaggt gagtgtctca ttaactgtat caagatgctt 2521 atgttataga attttttaaa caaccttttg aaatataaat cacacataac aattcaaaaa 2581 aaaaaaaaaa aaaaaaaaaa aaa //