LOCUS BC028303 1253 bp mRNA linear HUM 21-OCT-2003
DEFINITION Homo sapiens SAM and SH3 domain containing 1, mRNA (cDNA clone
IMAGE:5001535), partial cds.
ACCESSION BC028303
VERSION BC028303.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1253)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1253)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (10-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 52 Row: f Column: 22.
FEATURES Location/Qualifiers
source 1..1253
/db_xref="H-InvDB:HIT000091562"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5001535"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_10"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..1253
/gene="SASH1"
/gene_synonym="KIAA0790"
/db_xref="GeneID:23328"
/db_xref="MIM:607955"
CDS <1..730
/gene="SASH1"
/gene_synonym="KIAA0790"
/codon_start=2
/product="SASH1 protein"
/protein_id="AAH28303.1"
/db_xref="GeneID:23328"
/db_xref="MIM:607955"
/translation="GPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAP
GSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID
LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGG
LTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGIT
EERHIRKLLSAARLFKLPPGPEAM"
misc_feature 506..703
/gene="SASH1"
/gene_synonym="KIAA0790"
/note="SAM; Region: Sterile alpha motif. Widespread domain
in signalling and nuclear proteins. In EPH-related
tyrosine kinases, appears to mediate cell-cell initiated
signal transduction via the binding of SH2-containing
proteins to a conserved tyrosine that is phosphorylated.
In many cases mediates homodimerisation"
/db_xref="CDD:smart00454"
BASE COUNT 299 a 376 c 331 g 247 t
ORIGIN
1 gggccccagt ggggccctcc ccagtcccga tgcgccatgc ctgccagtga aaaggggcag
61 ccccgccagc cccaccagcc ctagcgactg tcccccagca ctggctccca ggcctctctc
121 agggcaggcg cctggcagcc caccaagcac aaggccgccc ccctggctct cagagctccc
181 cgagaacaca agcctccagg agcacggtgt gaagctgggc ccggctttga ccaggaaggt
241 ctcctgtgcc cggggagtgg atctagaaac gctcactgaa aacaagctgc acgctgaagg
301 catcgatctc acggaggagc cgtattctga taagcatggc cgctgtggga ttcctgaagc
361 cctggtgcag agatacgcag aggacttgga tcagcccgag cgggacgtcg ccgccaacat
421 ggaccagatc cgggtgaagc agcttcggaa gcagcaccgc atggcgattc caagtggtgg
481 actcacggaa atctgccgaa agcccgtctc tcctgggtgc atttcgtctg tgtcagattg
541 gctcatttcc atcggtctgc ccatgtacgc cggcaccctc tccaccgcgg gcttcagcac
601 actgagccaa gtgccttctc tgtctcacac ttgccttcag gaggccggca tcacagagga
661 gagacacata agaaagctcc tatctgcagc cagactcttc aaactgccgc caggccctga
721 ggccatgtag ccaggcccgg aatgggcctc tctggacaag agccaccctt tcactgtgca
781 tatgatgctg atgcaattcc tccatcatct ctggacgtgc agaccagatc cagaagaaag
841 gcctggcgtg tggccaaaca gcgtgaaacc ttggcacagg actgaggatc ctctcctcca
901 gaaaagcccc ctcgaggaaa taaattagtg cggttctctt tgacctccaa agacaagaca
961 agcacttatt tttattttca gaagacaaaa gaaccaagat gccaactggc tgcgaatgct
1021 ctatctccag tctgtctctg tgtactggta gaggctggga ggagtagggg gcagcctgtt
1081 ccatttctga tagtgccctt gctcttctgt ctgtcatctt gcaggatgcc cgagggccag
1141 atgggcttag ctaggccaaa gtaacagact caagagttat tgtacattac tgaccacgct
1201 catttgttca aaagttagaa catctggctg caccaggaaa aaaaaaaaaa aaa
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