LOCUS BC028210 2651 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens inducible T-cell co-stimulator, mRNA (cDNA clone
MGC:40066 IMAGE:5215237), complete cds.
ACCESSION BC028210
VERSION BC028210.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2651)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2651)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 62 Row: h Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 32483379.
FEATURES Location/Qualifiers
source 1..2651
/db_xref="H-InvDB:HIT000040488"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:40066 IMAGE:5215237"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2651
/gene="ICOS"
/gene_synonym="AILIM"
/gene_synonym="CD278"
/gene_synonym="MGC39850"
/db_xref="GeneID:29851"
/db_xref="HGNC:HGNC:5351"
/db_xref="MIM:604558"
CDS 36..635
/gene="ICOS"
/gene_synonym="AILIM"
/gene_synonym="CD278"
/gene_synonym="MGC39850"
/codon_start=1
/product="inducible T-cell co-stimulator"
/protein_id="AAH28210.1"
/db_xref="GeneID:29851"
/db_xref="HGNC:HGNC:5351"
/db_xref="MIM:604558"
/translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY
PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS
HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL
ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL"
BASE COUNT 776 a 548 c 509 g 818 t
ORIGIN
1 ctgaacgcga ggactgttaa ctgtttctgg caaacatgaa gtcaggcctc tggtatttct
61 ttctcttctg cttgcgcatt aaagttttaa caggagaaat caatggttct gccaattatg
121 agatgtttat atttcacaac ggaggtgtac aaattttatg caaatatcct gacattgtcc
181 agcaatttaa aatgcagttg ctgaaagggg ggcaaatact ctgcgatctc actaagacaa
241 aaggaagtgg aaacacagtg tccattaaga gtctgaaatt ctgccattct cagttatcca
301 acaacagtgt ctcttttttt ctatacaact tggaccattc tcatgccaac tattacttct
361 gcaacctatc aatttttgat cctcctcctt ttaaagtaac tcttacagga ggatatttgc
421 atatttatga atcacaactt tgttgccagc tgaagttctg gttacccata ggatgtgcag
481 cctttgttgt agtctgcatt ttgggatgca tacttatttg ttggcttaca aaaaagaagt
541 attcatccag tgtgcacgac cctaacggtg aatacatgtt catgagagca gtgaacacag
601 ccaaaaaatc tagactcaca gatgtgaccc tataatatgg aactctggca cccaggcatg
661 aagcacgttg gccagttttc ctcaacttga agtgcaagat tctcttattt ccgggaccac
721 ggagagtctg acttaactac atacatcttc tgctggtgtt ttgttcaatc tggaagaatg
781 actgtatcag tcaatgggga ttttaacaga ctgccttggt actgccgagt cctctcaaaa
841 caaacaccct cttgcaacca gctttggaga aagcccagct cctgtgtgct cactgggagt
901 ggaatccctg tctccacatc tgctcctagc agtgcatcag ccagtaaaac aaacacattt
961 acaagaaaaa tgttttaaag atgccagggg tactgaatct gcaaagcaaa tgagcagcca
1021 aggaccagca tctgtccgca tttcactatc atactacctc ttctttctgt agggatgaga
1081 attcctcttt taatcagtca agggagatgc ttcaaagctg gagctatttt atttctgaga
1141 tgttgatgtg aactgtacat tagtacatac tcagtactct ccttcaattg ctgaacccca
1201 gttgaccatt ttaccaagac tttagatgct ttcttgtgcc ctcaattttc tttttaaaaa
1261 tacttctaca tgactgcttg acagcccaac agccactctc aatagagagc tatgtcttac
1321 attctttcct ctgctgctca atagttttat atatctatgc atacatatat acacacatat
1381 gtatataaaa ttcataatga atatatttgc ctatattctc cctacaagaa tatttttgct
1441 ccagaaagac atgttctttt ctcaaattca gttaaaatgg tttactttgt tcaagttagt
1501 ggtaggaaac attgcccgga attgaaagca aatttatttt attatcctat tttctaccat
1561 tatctatgtt ttcatggtgc tattaattac aagtttagtt ctttttgtag atcatattaa
1621 aattgcaaac aaaatcatct ttaatgggcc agcattctca tggggtagag cagaatattc
1681 atttagcctg aaagctgcag ttactatagg ttgctgtcag actataccca tggtgcctct
1741 gggcttgaca ggtcaaaatg gtccccatca gcctggagca gccctccaga cctgggtgga
1801 attccagggt tgagagactc ccctgagcca gaggccacta ggtattcttg ctcccagagg
1861 ctgaagtcac cctgggaatc acagtggtct acctgcattc ataattccag gatctgtgaa
1921 gagcacatat gtgtcagggc acaattccct ctcataaaaa ccacacagcc tggaaattgg
1981 ccctggccct tcaagatagc cttctttaga atatgatttg gctagaaaga ttcttaaata
2041 tgtggaatat gattattctt agctggaata ttttctctac ttcctgtctg catgcccaag
2101 gcttctgaag cagccaatgt cgatgcaaca acatttgtaa ctttaggtaa actgggatta
2161 tgttgtagtt taacattttg taactgtgtg cttatagttt acaagtgaga cccgatatgt
2221 cattatgcat acttatatta tcttaagcat gtgtaatgct ggatgtgtac agtacagtac
2281 tgaacttgta atttgaatct agtatggtgt tctgttttca gctgacttgg acaacctgac
2341 tggctttgca caggtgttcc ctgagttgtt tgcaggtttc tgtgtgtggg gtggggtatg
2401 gggaggagaa ccttcatggt ggcccacctg gcctggttgt ccaagctgtg cctcgacaca
2461 tcctcatccc cagcatggga cacctcaaga tgaataataa ttcacaaaat ttctgtgaaa
2521 tcaaatccag ttttaagagg agccacttat caaagagatt ttaacagtag taagaaggca
2581 aagaataaac atttgatatt cagcaactga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2641 aaaaaaaaaa a
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