LOCUS BC020216 1235 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens aldo-keto reductase family 1, member C1 (dihydrodiol
dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase),
mRNA (cDNA clone MGC:31890 IMAGE:4662654), complete cds.
ACCESSION BC020216
VERSION BC020216.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1235)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1235)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (19-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 40 Row: h Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 56121816.
FEATURES Location/Qualifiers
source 1..1235
/db_xref="H-InvDB:HIT000038757"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:31890 IMAGE:4662654"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_18"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1235
/gene="AKR1C1"
/gene_synonym="2-ALPHA-HSD"
/gene_synonym="20-ALPHA-HSD"
/gene_synonym="C9"
/gene_synonym="DD1"
/gene_synonym="DDH"
/gene_synonym="H-37"
/gene_synonym="HAKRC"
/gene_synonym="MBAB"
/gene_synonym="MGC8954"
/db_xref="GeneID:1645"
/db_xref="HGNC:HGNC:384"
/db_xref="MIM:600449"
CDS 17..988
/gene="AKR1C1"
/gene_synonym="2-ALPHA-HSD"
/gene_synonym="20-ALPHA-HSD"
/gene_synonym="C9"
/gene_synonym="DD1"
/gene_synonym="DDH"
/gene_synonym="H-37"
/gene_synonym="HAKRC"
/gene_synonym="MBAB"
/gene_synonym="MGC8954"
/codon_start=1
/product="aldo-keto reductase family 1, member C1
(dihydrodiol dehydrogenase 1; 20-alpha
(3-alpha)-hydroxysteroid dehydrogenase)"
/protein_id="AAH20216.1"
/db_xref="GeneID:1645"
/db_xref="HGNC:HGNC:384"
/db_xref="MIM:600449"
/translation="MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEA
GFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERS
LKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLA
KSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSA
LGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR
IRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY"
BASE COUNT 366 a 268 c 300 g 301 t
ORIGIN
1 caggctagtg acagaaatgg attcgaaata tcagtgtgtg aagctgaatg atggtcactt
61 catgcctgtc ctgggatttg gcacctatgc gcctgcagag gttcctaaaa gtaaagcttt
121 agaggccacc aaattggcaa ttgaagctgg cttccgccat attgattctg ctcatttata
181 caataatgag gagcaggttg gactggccat ccgaagcaag attgcagatg gcagtgtgaa
241 gagagaagac atattctaca cttcaaagct ttggtgcaat tcccatcgac cagagttggt
301 ccgaccagcc ttggaaaggt cactgaaaaa tcttcaattg gattatgttg acctctacct
361 tattcatttt ccagtgtctg taaagccagg tgaggaagtg atcccaaaag atgaaaatgg
421 aaaaatacta tttgacacag tggatctctg tgccacgtgg gaggccgtgg agaagtgtaa
481 agatgcagga ttggccaagt ccatcggggt gtccaacttc aaccgcaggc agctggagat
541 gatcctcaac aagccagggc tcaagtacaa gcctgtctgc aaccaggtgg aatgtcatcc
601 ttacttcaac cagagaaaac tgctggattt ctgcaagtca aaagacattg ttctggttgc
661 ctatagtgct ctgggatccc accgagaaga accatgggtg gacccgaact ccccggtgct
721 cttggaggac ccagtccttt gtgccttggc aaaaaagcac aagcgaaccc cagccctgat
781 tgccctgcgc taccagctac agcgtggggt tgtggtcctg gccaagagct acaatgagca
841 gcgcatcaga cagaacgtgc aggtgtttga attccagttg acttcagagg agatgaaagc
901 catagatggc ctaaacagaa atgtgcgata tttgaccctt gatatttttg ctggcccccc
961 taattatcca ttttctgatg aatattaaca tggagggcat tgcatgaggt ctgccagaag
1021 gccctgcgtg tggatggtga cacagaggat ggctctatgc tggtgactgg acacatcgcc
1081 tctggttaaa tctctcctgc ttggtgattt cagcaagcta cagcaaagcc cattggccag
1141 aaaggaaaga caataatttt gttttttcat tttgaaaaaa ttaaatgctc tctcctaaaa
1201 aaaaaaaaaa acaaaaaaaa aaaaaaaaaa aaaaa
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