LOCUS       BC014482                3347 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens signal transducer and activator of transcription 3
            (acute-phase response factor), mRNA (cDNA clone MGC:23173
            IMAGE:4909141), complete cds.
ACCESSION   BC014482
VERSION     BC014482.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3347)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-SEP-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 34 Row: p Column: 2.
FEATURES             Location/Qualifiers
     source          1..3347
                     /db_xref="H-InvDB:HIT000036730"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:23173 IMAGE:4909141"
                     /tissue_type="Pancreas, epithelioid carcinoma"
                     /clone_lib="NIH_MGC_42"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..3347
                     /gene="STAT3"
                     /gene_synonym="APRF"
                     /gene_synonym="FLJ20882"
                     /gene_synonym="MGC16063"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
     CDS             133..2445
                     /gene="STAT3"
                     /gene_synonym="APRF"
                     /gene_synonym="FLJ20882"
                     /gene_synonym="MGC16063"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     3 (acute-phase response factor)"
                     /protein_id="AAH14482.1"
                     /db_xref="GI:15680254"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:HGNC:11364"
                     /db_xref="MIM:102582"
                     /translation="MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWA
                     YAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIA
                     RIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQ
                     KMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIV
                     SELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQ
                     TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
                     RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTK
                     VMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
                     KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
                     SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLD
                     NIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWV
                     EKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEA
                     FGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNN
                     GEGAEPSAGGQFESLTFDMELTSECATSPM"
BASE COUNT          909 a          829 c          859 g          750 t
ORIGIN      
        1 cgctgtctct ccccctcggc tcggagaggc ccttcggcct gagggagcct cgccgcccgt
       61 ccccggcaca cgcgcagccc cggcctctcg gcctctgccg gagaaacagt tgggacccct
      121 gattttagca ggatggccca atggaatcag ctacagcagc ttgacacacg gtacctggag
      181 cagctccatc agctctacag tgacagcttc ccaatggagc tgcggcagtt tctggcccct
      241 tggattgaga gtcaagattg ggcatatgcg gccagcaaag aatcacatgc cactttggtg
      301 tttcataatc tcctgggaga gattgaccag cagtatagcc gcttcctgca agagtcgaat
      361 gttctctatc agcacaatct acgaagaatc aagcagtttc ttcagagcag gtatcttgag
      421 aagccaatgg agattgcccg gattgtggcc cggtgcctgt gggaagaatc acgccttcta
      481 cagactgcag ccactgcggc ccagcaaggg ggccaggcca accaccccac agcagccgtg
      541 gtgacggaga agcagcagat gctggagcag caccttcagg atgtccggaa gagagtgcag
      601 gatctagaac agaaaatgaa agtggtagag aatctccagg atgactttga tttcaactat
      661 aaaaccctca agagtcaagg agacatgcaa gatctgaatg gaaacaacca gtcagtgacc
      721 aggcagaaga tgcagcagct ggaacagatg ctcactgcgc tggaccagat gcggagaagc
      781 atcgtgagtg agctggcggg gcttttgtca gcgatggagt acgtgcagaa aactctcacg
      841 gacgaggagc tggctgactg gaagaggcgg caacagattg cctgcattgg aggcccgccc
      901 aacatctgcc tagatcggct agaaaactgg ataacgtcat tagcagaatc tcaacttcag
      961 acccgtcaac aaattaagaa actggaggag ttgcagcaaa aagtttccta caaaggggac
     1021 cccattgtac agcaccggcc gatgctggag gagagaatcg tggagctgtt tagaaactta
     1081 atgaaaagtg cctttgtggt ggagcggcag ccctgcatgc ccatgcatcc tgaccggccc
     1141 ctcgtcatca agaccggcgt ccagttcact actaaagtca ggttgctggt caaattccct
     1201 gagttgaatt atcagcttaa aattaaagtg tgcattgaca aagactctgg ggacgttgca
     1261 gctctcagag gatcccggaa atttaacatt ctgggcacaa acacaaaagt gatgaacatg
     1321 gaagaatcca acaacggcag cctctctgca gaattcaaac acttgaccct gagggagcag
     1381 agatgtggga atgggggccg agccaattgt gatgcttccc tgattgtgac tgaggagctg
     1441 cacctgatca cctttgagac cgaggtgtat caccaaggcc tcaagattga cctagagacc
     1501 cactccttgc cagttgtggt gatctccaac atctgtcaga tgccaaatgc ctgggcgtcc
     1561 atcctgtggt acaacatgct gaccaacaat cccaagaatg taaacttttt taccaagccc
     1621 ccaattggaa cctgggatca agtggccgag gtcctgagct ggcagttctc ctccaccacc
     1681 aagcgaggac tgagcatcga gcagctgact acactggcag agaaactctt gggacctggt
     1741 gtgaattatt cagggtgtca gatcacatgg gctaaatttt gcaaagaaaa catggctggc
     1801 aagggcttct ccttctgggt ctggctggac aatatcattg accttgtgaa aaagtacatc
     1861 ctggcccttt ggaacgaagg gtacatcatg ggctttatca gtaaggagcg ggagcgggcc
     1921 atcttgagca ctaagcctcc aggcaccttc ctgctaagat tcagtgaaag cagcaaagaa
     1981 ggaggcgtca ctttcacttg ggtggagaag gacatcagcg gtaagaccca gatccagtcc
     2041 gtggaaccat acacaaagca gcagctgaac aacatgtcat ttgctgaaat catcatgggc
     2101 tataagatca tggatgctac caatatcctg gtgtctccac tggtctatct ctatcctgac
     2161 attcccaagg aggaggcatt cggaaagtat tgtcggccag agagccagga gcatcctgaa
     2221 gctgacccag gtagcgctgc cccatacctg aagaccaagt ttatctgtgt gacaccaacg
     2281 acctgcagca ataccattga cctgccgatg tccccccgca ctttagattc attgatgcag
     2341 tttggaaata atggtgaagg tgctgaaccc tcagcaggag ggcagtttga gtccctcacc
     2401 tttgacatgg agttgacctc ggagtgcgct acctccccca tgtgaggagc tgagaacgga
     2461 agctgcagaa agatacgact gaggcgccta cctgcattct gccacccctc acacagccaa
     2521 accccagatc atctgaaact actaactttg tggttccaga ttttttttaa tctcctactt
     2581 ctgctatctt tgagcaatct gggcactttt aaaaatagag aaatgagtga atgtgggtga
     2641 tctgctttta tctaaatgca aataaggatg tgttctctga gacccatgat caggggatgt
     2701 ggcggggggt ggctagaggg agaaaaagga aatgtcttgt gttgttttgt tcccctgccc
     2761 tcctttctca gcagcttttt gttattgttg ttgttgttct tagacaagtg cctcctggtg
     2821 cctgcggcat ccttctgcct gtttctgtaa gcaaatgcca caggccacct atagctacat
     2881 actcctggca ttgcactttt taaccttgct gacatccaaa tagaagatag gactatctaa
     2941 gccctaggtt tctttttaaa ttaagaaata ataacaatta aagggcaaaa aacactgtat
     3001 cagcatagcc tttctgtatt taagaaactt aagcagccgg gcatggttgc tcacgcctgt
     3061 aatcccagca ctttgggagg ccgaggcgga tcataaggtc aggagatcaa gaccatcctg
     3121 gctaacacgg tgaaaccccg tctctactaa aagtacaaaa aattagctgg gtgtggtggt
     3181 gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatcgctt gaacctgaga
     3241 ggcggaggtt gcagtgagcc aaaattgcac cactgcacac tgcactccat cctgggcgac
     3301 agtctgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//