LOCUS BC010858 2655 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens enhancer of zeste homolog 2 (Drosophila), mRNA (cDNA
clone MGC:9169 IMAGE:3901250), complete cds.
ACCESSION BC010858
VERSION BC010858.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2655)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2655)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 25, 2003 this sequence version replaced BC010858.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 14 Row: n Column: 6
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 23510382.
FEATURES Location/Qualifiers
source 1..2655
/db_xref="H-InvDB:HIT000035077"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9169 IMAGE:3901250"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_70"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2655
/gene="EZH2"
/gene_synonym="ENX-1"
/gene_synonym="EZH1"
/gene_synonym="MGC9169"
/db_xref="GeneID:2146"
/db_xref="HGNC:HGNC:3527"
/db_xref="MIM:601573"
CDS 123..2378
/gene="EZH2"
/gene_synonym="ENX-1"
/gene_synonym="EZH1"
/gene_synonym="MGC9169"
/codon_start=1
/product="enhancer of zeste homolog 2 (Drosophila)"
/protein_id="AAH10858.1"
/db_xref="GeneID:2146"
/db_xref="HGNC:HGNC:3527"
/db_xref="MIM:601573"
/translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSS
NRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLN
AVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGD
RECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKF
PSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQ
SLHSFHTLFCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLE
GAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTE
TGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIG
TYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHC
RKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCR
CKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPS
DVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDA
TRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALK
YVGIEREMEIP"
BASE COUNT 836 a 538 c 644 g 637 t
ORIGIN
1 tccggtcgcg tccgacaccc ggtgggactc agaaggcagt ggagccccgg cggcggcggc
61 ggcggcgcgc gggggcgacg cgcgggaaca acgcgagtcg gcgcgcggga cgaagaataa
121 tcatgggcca gactgggaag aaatctgaga agggaccagt ttgttggcgg aagcgtgtaa
181 aatcagagta catgcgactg agacagctca agaggttcag acgagctgat gaagtaaaga
241 gtatgtttag ttccaatcgt cagaaaattt tggaaagaac ggaaatctta aaccaagaat
301 ggaaacagcg aaggatacag cctgtgcaca tcctgacttc tgtgagctca ttgcgcggga
361 ctagggagtg ttcggtgacc agtgacttgg attttccaac acaagtcatc ccattaaaga
421 ctctgaatgc agttgcttca gtacccataa tgtattcttg gtctccccta cagcagaatt
481 ttatggtgga agatgaaact gttttacata acattcctta tatgggagat gaagttttag
541 atcaggatgg tactttcatt gaagaactaa taaaaaatta tgatgggaaa gtacacgggg
601 atagagaatg tgggtttata aatgatgaaa tttttgtgga gttggtgaat gcccttggtc
661 aatataatga tgatgacgat gatgatgatg gagacgatcc tgaagaaaga gaagaaaagc
721 agaaagatct ggaggatcac cgagatgata aagaaagccg cccacctcgg aaatttcctt
781 ctgataaaat ttttgaagcc atttcctcaa tgtttccaga taagggcaca gcagaagaac
841 taaaggaaaa atataaagaa ctcaccgaac agcagctccc aggcgcactt cctcctgaat
901 gtacccccaa catagatgga ccaaatgcta aatctgttca gagagagcaa agcttacact
961 cctttcatac gcttttctgt aggcgatgtt ttaaatatga ctgcttccta catcgtaagt
1021 gcaattattc ttttcatgca acacccaaca cttataagcg gaagaacaca gaaacagctc
1081 tagacaacaa accttgtgga ccacagtgtt accagcattt ggagggagca aaggagtttg
1141 ctgctgctct caccgctgag cggataaaga ccccaccaaa acgtccagga ggccgcagaa
1201 gaggacggct tcccaataac agtagcaggc ccagcacccc caccattaat gtgctggaat
1261 caaaggatac agacagtgat agggaagcag ggactgaaac ggggggagag aacaatgata
1321 aagaagaaga agagaagaaa gatgaaactt cgagctcctc tgaagcaaat tctcggtgtc
1381 aaacaccaat aaagatgaag ccaaatattg aacctcctga gaatgtggag tggagtggtg
1441 ctgaagcctc aatgtttaga gtcctcattg gcacttacta tgacaatttc tgtgccattg
1501 ctaggttaat tgggaccaaa acatgtagac aggtgtatga gtttagagtc aaagaatcta
1561 gcatcatagc tccagctccc gctgaggatg tggatactcc tccaaggaaa aagaagagga
1621 aacaccggtt gtgggctgca cactgcagaa agatacagct gaaaaaggac ggctcctcta
1681 accatgttta caactatcaa ccctgtgatc atccacggca gccttgtgac agttcgtgcc
1741 cttgtgtgat agcacaaaat ttttgtgaaa agttttgtca atgtagttca gagtgtcaaa
1801 accgctttcc gggatgccgc tgcaaagcac agtgcaacac caagcagtgc ccgtgctacc
1861 tggctgtccg agagtgtgac cctgacctct gtcttacttg tggagccgct gaccattggg
1921 acagtaaaaa tgtgtcctgc aagaactgca gtattcagcg gggctccaaa aagcatctat
1981 tgctggcacc atctgacgtg gcaggctggg ggatttttat caaagatcct gtgcagaaaa
2041 atgaattcat ctcagaatac tgtggagaga ttatttctca agatgaagct gacagaagag
2101 ggaaagtgta tgataaatac atgtgcagct ttctgttcaa cttgaacaat gattttgtgg
2161 tggatgcaac ccgcaagggt aacaaaattc gttttgcaaa tcattcggta aatccaaact
2221 gctatgcaaa agttatgatg gttaacggtg atcacaggat aggtattttt gccaagagag
2281 ccatccagac tggcgaagag ctgttttttg attacagata cagccaggct gatgccctga
2341 agtatgtcgg catcgaaaga gaaatggaaa tcccttgaca tctgctacct cctcccccct
2401 cctctgaaac agctgcctta gcttcaggaa cctcgagtac tgtgggcaat ttagaaaaag
2461 aacatgcagt ttgaaattct gaatttgcaa agtactgtaa gaataattta tagtaatgag
2521 tttaaaaatc aactttttat tgccttctca ccagctgcaa agtgttttgt accagtgaat
2581 ttttgcaata atgcagtatg gtacattttt caactttgaa taaagaatac ttgaacttga
2641 aaaaaaaaaa aaaaa
//