LOCUS BC008145 1448 bp mRNA linear HUM 30-JAN-2008 DEFINITION Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1, mRNA (cDNA clone MGC:17277 IMAGE:4180383), complete cds. ACCESSION BC008145 VERSION BC008145.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1448) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1448) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (22-MAY-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: David N. Louis, M.D. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 12 Row: k Column: 1 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 18375500. FEATURES Location/Qualifiers source 1..1448 /db_xref="H-InvDB:HIT000033654" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:17277 IMAGE:4180383" /tissue_type="Brain, anaplastic oligodendroglioma with 1p/19q loss" /clone_lib="NCI_CGAP_Brn67" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1448 /gene="APEX1" /gene_synonym="APE" /gene_synonym="APE1" /gene_synonym="APEN" /gene_synonym="APX" /gene_synonym="HAP1" /gene_synonym="REF-1" /gene_synonym="REF1" /db_xref="GeneID:328" /db_xref="HGNC:HGNC:587" /db_xref="MIM:107748" CDS 216..1172 /gene="APEX1" /gene_synonym="APE" /gene_synonym="APE1" /gene_synonym="APEN" /gene_synonym="APX" /gene_synonym="HAP1" /gene_synonym="REF-1" /gene_synonym="REF1" /codon_start=1 /product="APEX nuclease (multifunctional DNA repair enzyme) 1" /protein_id="AAH08145.1" /db_xref="GeneID:328" /db_xref="HGNC:HGNC:587" /db_xref="MIM:107748" /translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL YEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVA EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK NVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL" BASE COUNT 399 a 345 c 373 g 331 t ORIGIN 1 ggagctaggc tgccatcggg ccggtgcaga tacggggttg ctcttttgct cataagaggg 61 gcttcgctgg cagtctgaac ggcaagcttg agtcaggacc cttaattaag atcctcaatt 121 ggctggaggg cagatctcgc gagtagggca acgcggtaaa aatattgctt cggtgggtga 181 cgcggtacag ctgcccaagg gcgttcgtaa cgggaatgcc gaagcgtggg aaaaagggag 241 cggtggcgga agacggggat gagctcagga cagagccaga ggccaagaag agtaagacgg 301 ccgcaaagaa aaatgacaaa gaggcagcag gagagggccc agccctgtat gaggaccccc 361 cagatcagaa aacctcaccc agtggcaaac ctgccacact caagatctgc tcttggaatg 421 tggatgggct tcgagcctgg attaagaaga aaggattaga ttgggtaaag gaagaagccc 481 cagatatact gtgccttcaa gagaccaaat gttcagagaa caaactacca gctgaacttc 541 aggagctgcc tggactctct catcaatact ggtcagctcc ttcggacaag gaagggtaca 601 gtggcgtggg cctgctttcc cgccagtgcc cactcaaagt ttcttacggc ataggcgagg 661 aggagcatga tcaggaaggc cgggtgattg tggctgaatt tgactcgttt gtgctggtaa 721 cagcatatgt acctaatgca ggccgaggtc tggtacgact ggagtaccgg cagcgctggg 781 atgaagcctt tcgcaagttc ctgaagggcc tggcttcccg aaagcccctt gtgctgtgtg 841 gagacctcaa tgtggcacat gaagaaattg accttcgcaa ccccaagggg aacaaaaaga 901 atgctggctt cacgccacaa gagcgccaag gcttcgggga attactgcag gctgtgccac 961 tggctgacag ctttaggcac ctctacccca acacacccta tgcctacacc ttttggactt 1021 atatgatgaa tgctcgatcc aagaatgttg gttggcgcct tgattacttt ttgttgtccc 1081 actctctgtt acctgcattg tgtgacagca agatccgttc caaggccctc ggcagtgatc 1141 actgtcctat caccctatac ctagcactgt gacaccaccc ctaaatcact ttgagcctgg 1201 gaaataagcc ccctcaacca ccattccttc tttaaacact cttcagagaa atctgcattc 1261 tatttctcat gtataaaact aggaatcctc caaccaggct cctgtgatag agttctttta 1321 agcccaagat tttttatttg agggtttttt gttttttaaa aaaaaattga acaaagacta 1381 ctaatgactt tgtttgaatt atccacatga aaataaagag ccatagtttc aaaaaaaaaa 1441 aaaaaaaa //