LOCUS BC003631 1314 bp mRNA linear HUM 05-NOV-2003 DEFINITION Homo sapiens S-adenosylhomocysteine hydrolase-like 1, mRNA (cDNA clone IMAGE:3010755), partial cds. ACCESSION BC003631 VERSION BC003631.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1314) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1314) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (26-FEB-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Oct 28, 2003 this sequence version replaced BC003631.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Institute for Systems Biology http://www.systemsbiology.org contact: amadan@systemsbiology.org Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 3 Row: b Column: 6. FEATURES Location/Qualifiers source 1..1314 /db_xref="H-InvDB:HIT000086259" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="IMAGE:3010755" /tissue_type="Muscle, rhabdomyosarcoma" /clone_lib="NIH_MGC_17" /lab_host="DH10B-R" /note="Vector: pOTB7" gene <1..1314 /gene="AHCYL1" /gene_synonym="DCAL" /gene_synonym="IRBIT" /gene_synonym="XPVKONA" /db_xref="GeneID:10768" /db_xref="MIM:607826" CDS <1..602 /gene="AHCYL1" /gene_synonym="DCAL" /gene_synonym="IRBIT" /gene_synonym="XPVKONA" /codon_start=3 /product="AHCYL1 protein" /protein_id="AAH03631.2" /db_xref="GeneID:10768" /db_xref="MIM:607826" /translation="ALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTG NKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKR VVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEY VASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY" misc_feature 3..575 /gene="AHCYL1" /gene_synonym="DCAL" /gene_synonym="IRBIT" /gene_synonym="XPVKONA" /note="AdoHcyase; Region: S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and Hyc is sufficiently fast, so that the net reaction is in the direction of hydrolysis. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homooligomers of 45-50kDa subunits, each binding one molecule of NAD+" /db_xref="CDD:cd00401" BASE COUNT 363 a 301 c 266 g 384 t ORIGIN 1 aagctcttgg agcaattgtc tacattaccg aaatcgaccc catctgtgct ctgcaggcct 61 gcatggatgg gttcagggtg gtaaagctaa atgaagtcat ccggcaagtc gatgtcgtaa 121 taacttgcac aggaaataag aatgtagtga cacgggagca cttggatcgc atgaaaaaca 181 gttgtatcgt atgcaatatg ggccactcca acacagaaat cgatgtgacc agcctccgca 241 ctccggagct gacgtgggag cgagtacgtt ctcaggtgga ccatgtcatc tggccagatg 301 gcaaacgagt tgtcctcctg gcagagggtc gtctactcaa tttgagctgc tccacagttc 361 ccacctttgt tctgtccatc acagccacaa cacaggcttt ggcactgata gaactctata 421 atgcacccga ggggcgatac aagcaggatg tgtacttgct tcctaagaaa atggatgaat 481 acgttgccag cttgcatctg ccatcatttg atgcccacct tacagagctg acagatgacc 541 aagcaaaata tctgggactc aacaaaaatg ggccattcaa acctaattat tacagatact 601 aatggaccat actaccaagg accagtccac ctgaaccaca cactctaaag aaatattttt 661 taagataact tttattttct tcttactcct ttcctcttga tttttttcct ataatttcat 721 tcttgttttt tcatctcatt atccaagttc tgcagaccac acaggaactt gcttcatggc 781 tctttagatg aaatagaagt tcagggttcc tcactctagt cactaaagaa ggattttact 841 ctcccagccc agaaaggtga ttctttcttt accatttctg gggactttag tcttaattag 901 gtaccttatt aacaggaaat gctaaggtac cttctctgtg gaacaatctg caatgtctaa 961 atcgccttaa aagagcccat ttcttagctg ctgaaatcag tgctctttca cttcttcaga 1021 gaagcaggga tggtacctac ccggcaggta ggttagatgt gggtggtgca tgttaatttc 1081 ccttagaagt tccaagccct gtttcctgcg taaaggtggt atgtccagtt cagagatgtg 1141 tataatgagc atggcttgtt aagatcagga ggcccacttg gatttatagt atagcccttc 1201 ctccactccc accagacttg ctcatttttc gagtttttaa ctagactaca ctctattgag 1261 tttaattttg tcctctagga tttatttctg ttgtccaaaa aaaaaaaaaa aaaa //