LOCUS AY635582 2082 bp mRNA linear HUM 14-SEP-2005
DEFINITION Homo sapiens glucuronyl C5-epimerase (GLCE) mRNA, complete cds.
ACCESSION AY635582
VERSION AY635582.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2082)
AUTHORS Ghiselli,G. and Agrawal,A.
TITLE The human D-glucuronyl C5-epimerase gene is transcriptionally
activated through the beta-catenin-TCF4 pathway
JOURNAL Biochem. J. 390 (PT 2), 493-499 (2005)
PUBMED 15853773
REFERENCE 2 (bases 1 to 2082)
AUTHORS Ghiselli,G.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2004) Pathology Cell Biology, Thomas Jefferson
University, 1020 Locust Street, JAH 371, Philadelphia, PA 19107,
USA
FEATURES Location/Qualifiers
source 1..2082
/db_xref="H-InvDB:HIT000255802"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2082
/gene="GLCE"
CDS 229..2082
/gene="GLCE"
/function="catalyzes the conversion of D-glucuronic acid
(GlcA) to L-iduronic acid (IdoA) units during the
biosynthesis of heparin and heparan sulfate"
/codon_start=1
/product="glucuronyl C5-epimerase"
/protein_id="AAT48654.1"
/translation="MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSS
SGFRVDGFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGL
KYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSK
VYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYG
LSHYSKNLTEKPPHIEVYETAEDRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAP
ETSEGVSLQLGNTKDFIISFDLKFLTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKE
RDIYYGIGPRTSWSTVTRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLD
NITISTTAHMAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQA
ISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNKHDWYEEYPTTPSSFV
LNGFMYSLIGLYDLKETAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFM
LGIAPNLARWDYHTTHINQLQLLSTIDESPVFKEFVKRWKSYLKGSRAKHN"
BASE COUNT 609 a 438 c 482 g 553 t
ORIGIN
1 cacacaagcg cttccttgcc gagaggctgg agctgcggca ccgcaggcct gagccacccc
61 ttctctgctg tctccttctc ttcctcaggg ctcccgtgtc tgctcgccct ccgacgctgc
121 tcaggaattt gacaagaaac tgaagttttg attcagatat attttgaatt gaaaccagag
181 atgttctaga gtttagattc tttcatttga ttaaggtatg gtctgaatat gcgttgcttg
241 gcagctcggg tcaactataa gactttgatt attatctgcg cactcttcac tttggtcaca
301 gtacttttgt ggaataagtg ttccagtgac aaagcaatcc agtttccacg gcgttcgagt
361 agtggcttca gagtggatgg gtttgaaaaa agagcagcag catctgagag taacaactat
421 atgaaccacg tggccaaaca acagtctgag gaagcattcc ctcaggaaca gcagaaagca
481 ccccctgttg ttgggggctt caatagcaat gtgggaagta aggtgttagg gctcaaatat
541 gaagaaattg actgtctcat aaatgatgaa cacacaatta aagggagacg agaggggaac
601 gaagtctttc ttccattcac ttgggttgag aaatattttg atgtttatgg aaaggtggtt
661 cagtatgatg gctatgatcg gtttgaattc tctcatagct attccaaagt ctatgcacag
721 agagccccct atcaccccga tggtgtgttt atgtcttttg aaggctacaa tgtggaagtc
781 cgagacagag tcaagtgcat aagtggggtt gaaggtgtgc cattatctac acaatgggga
841 cctcaaggct atttctatcc aatccagatt gcacagtatg gattaagtca ttacagcaag
901 aatctaactg agaaacctcc tcacatagag gtatatgaaa cagcagaaga cagagacaaa
961 aacaagccta atgactggac tgtgccaaag ggctgcttta tggcgaatgt ggctgataag
1021 tctagattca ccaatgtcaa acagtttatt gcaccagaaa ccagtgaagg tgtatccttg
1081 caactgggaa acacaaaaga ttttattatt tcatttgacc tcaagttctt gacaaatgga
1141 agtgtgtccg tggttctaga gaccacagaa aagaatcagc tcttcactat acattatgtc
1201 tcaaatgctc agctaattgc ttttaaagaa agagatatat actatggcat tgggcccaga
1261 acttcatgga gcacagttac cagggacctg gtcactgacc tcaggaaagg agtgggtctt
1321 tcaaacacaa aagctgtcaa gccaaccaaa ataatgccca agaaggtggt taggttgatt
1381 gcaaaaggta agggattcct cgacaacatt accatctcta ccacagccca catggctgca
1441 ttttttgctg ctagtgattg gctagtaagg aaccaggatg agaaaggtgg ctggccaatt
1501 atggtgaccc gtaagttagg ggaagggttc aagtctttag agccaggatg gtattctgcc
1561 atggcccaag ggcaagccat ttctacatta gtcagggcct atctgttaac aaaagaccat
1621 atattcctca attcagcttt aagggcaaca gccccttata agtttctatc tgagcagcat
1681 ggagttaaag ctgtgtttat gaataaacat gactggtatg aagaatatcc aaccacacct
1741 agctcttttg ttttaaatgg ctttatgtat tctttaattg ggctgtatga cttaaaagaa
1801 actgcagggg aaaaactcgg aaaagaagca aggtccttgt atgagcgtgg catggaatct
1861 cttaaagcca tgctgccctt gtatgacact ggctcaggaa ccatctatga cctccgtcac
1921 ttcatgcttg gcatcgctcc taacctggct cgctgggact atcataccac ccacatcaat
1981 cagttgcagc tactcagtac cattgatgag tccccagtct tcaaagaatt tgtcaagagg
2041 tggaaaagct accttaaagg cagcagggca aagcacaact ag
//