LOCUS AY177664 3579 bp mRNA linear HUM 12-FEB-2004
DEFINITION Homo sapiens desmoglein 4 preproprotein (DSG4) mRNA, complete cds.
ACCESSION AY177664
VERSION AY177664.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3579)
AUTHORS Whittock,N.V. and Bower,C.
TITLE Genetic evidence for a novel human desmosomal cadherin, desmoglein
4
JOURNAL J. Invest. Dermatol. 120 (4), 523-530 (2003)
PUBMED 12648213
REFERENCE 2 (bases 1 to 3579)
AUTHORS Whittock,N.V.
TITLE Direct Submission
JOURNAL Submitted (10-NOV-2002) Center for Molecular Genetics, Institute of
Biomedical and Clinical Science, Peninsula Medical School, Old
Pathology Building, Barrack Road, Exeter EX2 5DW, England
FEATURES Location/Qualifiers
source 1..3579
/db_xref="H-InvDB:HIT000084989"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q12"
gene 1..3579
/gene="DSG4"
5'UTR 1..135
/gene="DSG4"
CDS 136..3258
/gene="DSG4"
/note="desmosomal cadherin"
/codon_start=1
/product="desmoglein 4 preproprotein"
/protein_id="AAO47078.1"
/translation="MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTV
RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTI
NPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQS
VYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV
CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA
SIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVV
KMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAF
SVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSR
EFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS
PSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPI
LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS
NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWR
IEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGT
AVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRP
ANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFP
SHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNA
DPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASP
GVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVT
RYSNIHYTQQ"
sig_peptide 136..198
/gene="DSG4"
misc_feature 199..3255
/gene="DSG4"
/note="encodes desmoglein 4 proprotein"
mat_peptide 283..3255
/gene="DSG4"
/product="desmoglein 4"
3'UTR 3259..3579
/gene="DSG4"
BASE COUNT 1067 a 729 c 834 g 949 t
ORIGIN
1 caccacagtt atcacccatg ccctcctaaa agggtgtctc aaagcatatc tttctgtaga
61 gcagaattcg gaactgagaa gacgagggct caaattgaat ctcacaggat ttgcgtgcaa
121 gagaaaccca aaggaatgga ttggctcttc ttcagaaaca tttgcctttt gatcattcta
181 atggtggtga tggaagtaaa cagtgaattt attgttgagg tgaaggaatt tgacattgaa
241 aatggcacta caaaatggca aacagtcaga agacaaaagc gggagtggat caagtttgcc
301 gcagcctgtc gagaaggaga ggacaactcg aagaggaacc ccattgccaa aattcgatca
361 gactgcgaat cgaaccagaa gataacatac cggatttctg gagtagggat tgatcgacca
421 ccatatgggg tattcaccat taatcctcgc actggggaaa ttaacatcac ttcagtggta
481 gacagagaaa taactccact tttcttgatc tattgccggg ctctgaattc acggggtgaa
541 gatttagaaa ggcctcttga gcttagagtc aaagttatgg acataaatga taacgctcca
601 gtcttttcgc aaagtgtata cacagccagc attgaagaaa atagtgatgc caatacattg
661 gtagtaaagt tatgtgccac agatgcagat gaagaaaatc atctgaattc taaaattgcc
721 tacaagatcg tctctcagga gccatcaggt gcacccatgt tcattctgaa taggtacact
781 ggagaagtct gcaccatgtc cagtttcttg gacagagagc aacacagtat gtacaacctg
841 gttgtgagag gctcagatcg ggatggagct gcagatggac tgtcttctga gtgtgactgt
901 agaatcaagg ttttagacgt caacgataat ttccccacct tagagaaaac ttcatactca
961 gccagtattg aagagaattg tttaagttcg gaactgatac gattacaagc aattgatctt
1021 gatgaagaag gcactgataa ctggttggct caatatttaa ttctctctgg aaatgatggg
1081 aattggttcg atattcaaac agatccacaa accaatgaag gcattttgaa agttgtcaag
1141 atgctggatt atgaacaagc acctaacatt cagcttagta tcggagttaa aaaccaagct
1201 gattttcact actccgttgc ttctcaattc caaatgcacc caacccctgt gagaattcaa
1261 gttgttgatg tgagagaagg acctgcattt catccaagta ctatggcttt tagtgtgcgg
1321 gaaggaataa aaggaagttc cttattgaat tatgtgcttg gcacatatac agccatagat
1381 ttggacacag gaaaccctgc aacagatgtc agatatatca tagggcatga tgcaggcagc
1441 tggttaaaaa ttgattcaag aactggtgag atacaatttt ctagagaatt tgataagaag
1501 tcaaaatata ttatcaatgg gatatacaca gcagagatcc tggctataga tgatggctct
1561 ggaaaaacag ctacaggaac catatgtatt gaggttcctg atatcaatga ttattgtcca
1621 aacatttttc ctgaaagaag aaccatctgc attgactctc catcagtcct tatctctgtt
1681 aatgaacatt cttatgggtc tccgtttact ttctgtgttg ttgatgagcc accaggaata
1741 gctgacatgt gggatgtcag atcaacaaat gctacctcgg caatccttac ggctaagcag
1801 gttttatctc caggatttta tgaaatccca atcctggtga aggacagcta taacagagca
1861 tgtgaattgg cacaaatggt gcagttatat gcctgtgatt gcgatgacaa ccacatgtgc
1921 ctggactctg gtgccgcggg catctacaca gaggacataa ctggtgacac gtatgggcct
1981 gtcactgaag accaagctgg agtttcaaat gttggtcttg gaccagcagg gattggcatg
2041 atggttctgg gcatcctgct actgattttg gctccactct tgctgctcct gtgttgctgc
2101 aaacagagac agccagaagg cctgggaaca agatttgctc ctgtgcctga gggcggagaa
2161 ggagtgatgc agtcttggag aattgaaggg gcccatcccg aggacaggga tgtgtcaaat
2221 atatgtgcac ccatgacagc ctcaaatacc caggatcgga tggattcctc tgaaatctac
2281 accaacacct atgcagccgg gggcacggtg gaaggaggtg tatcgggagt ggagctcaac
2341 acaggtatgg ggacagccgt tggcctcatg gccgcagggg ccgcaggagc ctcaggggcc
2401 gcaaggaaga ggagctctac catgggaacc ctgcgggact acgctgacgc agacatcaac
2461 atggctttct tggacagcta cttctcggag aaagcgtatg cttatgcaga tgaagatgaa
2521 ggtcgaccag ccaatgactg cttgctcatt tatgaccacg agggagtcgg gtctcccgta
2581 ggctctattg gttgttgcag ttggattgtg gatgacttag atgaaagctg catggaaact
2641 ttagatccaa aatttaggac tcttgctgag atctgcttaa acacagaaat tgaaccattt
2701 ccttcacacc aggcttgtat accaatcagt actgacctcc ctttgctcgg acctaattac
2761 tttgttaatg aatcttcagg attgactccc tcagaagttg aattccaaga agaaatggca
2821 gcatctgaac ccgtggtcca tggggatatt attgtgactg agacttacgg taatgctgat
2881 ccatgtgtgc aacccactac aattattttt gatcctcagc ttgcacccaa tgttgtagta
2941 accgaagcag taatggcacc tgtctatgat attcaaggga atatttgtgt acctgctgag
3001 ttagcagatt acaacaatgt aatctatgct gagagagtac tggctagtcc tggtgtgcct
3061 gacatgagca atagtagcac gactgagggt tgtatgggac ctgtgatgag cggcaatatt
3121 ttagtagggc cagaaattca agtgatgcaa atgatgagtc cagaccttcc cataggccaa
3181 accgttggct ccacatcccc catgacatct cgacacagag taacacgata cagtaacata
3241 cattacaccc aacagtaagt gctttatggt cagtattcta tgtggagacc ttgcaccttg
3301 taatcatcaa tacatccacc aaaaatatat aatgtaccat atatattaat agtcaacaaa
3361 tactcagata ttctaaggtc aatgccatta tttgattata ccattttgag ggtgaatatg
3421 gctaggcact ttagataagc ctttttaaaa ttctttctga ttttaaataa tgcgtcaaaa
3481 aatgtgcaga aaatgtattg catcccttga tactgtctaa cgaatagcac ataactcata
3541 ttgtgaatcc tatgggtctt gaggcctgta gaaccaatc
//