LOCUS AY168788 3531 bp mRNA linear HUM 01-MAY-2004
DEFINITION Homo sapiens desmoglein 4 (DSG4) mRNA, complete cds.
ACCESSION AY168788
VERSION AY168788.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3531)
AUTHORS Nguyen,V.T.
TITLE Experimental Mouse Model-Passive Transfer of Nondesmoglein 1 and 3
Antibodies for Pemphigus Vulgaris
JOURNAL (in) Chan,L.S. (Ed.);
ANIMAL MODELS OF HUMAN INFLAMMATORY SKIN DISEASES;
CRC Press LLC, FL, USA (2003)
REFERENCE 2 (bases 1 to 3531)
AUTHORS Nguyen,V.T.
TITLE Novel Pemphigus Vulgaris Antigen Desmoglein 4 has an Important Role
in Mediating Keratinocyte Adhesion
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 3531)
AUTHORS Nguyen,V.T.
TITLE Direct Submission
JOURNAL Submitted (25-OCT-2002) Dermatology, University of California,
Davis, Neuroscience Building, 1515 Newton Court, Davis, CA 95616,
USA
FEATURES Location/Qualifiers
source 1..3531
/db_xref="H-InvDB:HIT000250885"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q12"
/cell_type="epidermal keratinocyte"
gene 1..3531
/gene="DSG4"
CDS 30..3209
/gene="DSG4"
/note="cadherin; keratinocyte adhesion molecule;
recombinant protein is recognized by Homo sapiens
pemphigus vulgaris antibody to desmoglein 3, a classical
autoimmune skin blistering disease antigen encoded by
GenBank Accession Number M76482; may have a role in
mediating keratinocyte adhesion"
/codon_start=1
/product="desmoglein 4"
/protein_id="AAO43657.1"
/translation="MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTV
RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTI
NPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQS
VYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV
CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA
SIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVV
KMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAF
SVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSR
EFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS
PSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPI
LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS
NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWR
IEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAA
GGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFL
DSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLD
PKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMA
ASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVP
AELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDL
PIGQTVGSTSPMTSRHRVTRYSNIHYTQQ"
BASE COUNT 1035 a 722 c 835 g 939 t
ORIGIN
1 ggatttgcgt gcaagagaaa cccaaaggaa tggattggct cttcttcaga aacatttgcc
61 ttttgatcat tctaatggtg gtgatggaag taaacagtga atttattgtt gaggtgaagg
121 aatttgacat tgaaaatggc actacaaaat ggcaaacagt cagaagacaa aagcgggagt
181 ggatcaagtt tgccgcagcc tgtcgagaag gagaggacaa ctcgaagagg aaccccattg
241 ccaaaattcg atcagactgc gaatcgaacc agaagataac ataccgaatt tctggagtag
301 ggattgatcg accaccatat ggggtattca ccattaatcc tcgcactggg gaaattaaca
361 tcacttcagt ggtagacaga gaaataactc cacttttctt gatctattgc cgggctctga
421 attcacgggg tgaagattta gaaaggcctc ttgagcttag agtcaaagtt atggacataa
481 atgataacgc tccagtcttt tcgcaaagtg tatacacagc cagtattgaa gaaaatagtg
541 atgccaatac attggtagta aagttatgtg ccacagatgc agatgaagaa aatcatctga
601 attctaaaat tgcctacaag atcgtctctc aggagccatc aggtgcaccc atgttcattc
661 tgaataggta cactggagaa gtctgcacca tgtccagttt cttggacaga gagcaacaca
721 gtatgtacaa cctggttgtg agaggctcag atcgggatgg agctgcagat ggactgtctt
781 ctgagtgtga ctgtagaatc aaggttttag acgtcaacga taatttcccc accttagaga
841 aaacttcata ctcagccagt attgaagaga attgtttaag ttcggaactg atacgattac
901 aagcaattga tcttgatgaa gaaggcactg ataactggtt ggctcaatat ttaattctct
961 ctggaaatga tgggaattgg ttcgatattc aaacagatcc acaaaccaat gaaggcattt
1021 tgaaagttgt caagatgctg gattatgaac aagcacctaa cattcagctt agtatcggag
1081 ttaaaaacca agctgatttt cactactccg ttgcttctca attccaaatg cacccaaccc
1141 ctgtgagaat tcaagttgtt gatgtgagag aaggacctgc atttcatcca agtactatgg
1201 cttttagtgt gcgggaagga ataaaaggaa gttccttatt gaattatgtg cttggcacat
1261 atacagccat agatttggac acaggaaacc ctgcaacaga tgtcagatat atcatagggc
1321 atgatgcagg cagctggtta aaaattgatt caagaactgg tgagatacaa ttttctagag
1381 aatttgataa gaagtcaaaa tatattatca atgggatata cacagcagag atcctggcta
1441 tagatgatgg ctctggaaaa acagctacag gaaccatatg tattgaggtt cctgatatca
1501 atgattattg tccaaacatt tttcctgaaa gaagaaccat ctgcattgac tctccatcag
1561 tccttatctc tgttaatgaa cattcttatg ggtctccgtt tactttctgt gttgttgatg
1621 agccaccagg aatagctgac atgtgggatg tcagatcaac aaatgctacc tcggcaatcc
1681 ttacggctaa gcaggtttta tctccaggat tttatgaaat cccaatcctg gtgaaggaca
1741 gctataacag agcatgtgaa ttggcacaaa tggtgcagtt atatgcctgt gattgcgatg
1801 acaaccacat gtgcctggac tctggtgccg cgggcatcta cacagaggac ataactggtg
1861 acacgtatgg gcctgtcact gaagaccaag ctggagtttc aaatgttggt cttggaccag
1921 cagggattgg catgatggtt ctgggcatcc tgctactgat tttggctcca ctcttgctgc
1981 tcctgtgttg ctgcaaacag agacagccag aaggcctggg aacaagattt gctcctgtgc
2041 ctgagggcgg agaaggagtg atgcagtctt ggagaattga aggggcccat cccgaggaca
2101 ggctttttag cgcctacgcc ttgccgggtg gtggtggcac cgcagacggc ggcggcagcg
2161 ttttaggcag atgcgcgctg caggcaactc cagcgctgtt aaaccaacat cctccctttt
2221 cagaaatcta caccaacacc tatgcagccg ggggcacggt ggaaggaggt gtatcgggag
2281 tggagctcaa cacaggtatg gggacagccg ttggcctcat ggccgcaggg gccgcaggag
2341 cctcaggggc cgcaaggaag aggagctcta ccatgggaac cctgcgggac tacgctgacg
2401 cagacatcaa catggctttc ttggacagct acttctcgga gaaagcgtat gcttatgcag
2461 atgaagatga aggtcgacca gccaatgact gcttgctcat ttatgaccac gagggagtcg
2521 ggtctcccgt aggctctatt ggttgttgca gttggattgt ggatgactta gatgaaagct
2581 gcatggaaac tttagatcca aaatttagga ctcttgctga gatctgctta aacacagaaa
2641 ttgaaccatt tccttcacac caggcttgta taccaatcag tactgacctc cctttgctcg
2701 gacctaatta ctttgttaat gaatcttcag gattgactcc ctcagaagtt gaattccaag
2761 aagaaatggc agcatctgaa cccgtggtcc atggggatat tattgtgact gagacttacg
2821 gtaatgctga tccatgtgtg caacccacta caattatttt tgatcctcag cttgcaccca
2881 atgttgtagt aaccgaagca gtaatggcac ctgtctatga tattcaaggg aatatttgtg
2941 tacctgctga gttagcagat tacaacaatg taatctatgc tgagagagta ctggctagtc
3001 ctggtgtgcc tgacatgagc aatagtagca cgactgaggg ttgtatggga cctgtgatga
3061 gcggcaatat tttagtaggg ccagaaattc aagtgatgca aatgatgagt ccagaccttc
3121 ccataggcca aaccgttggc tccacatccc ccatgacatc tcgacacaga gtaacacgat
3181 acagtaacat acattacacc caacagtaag tgctttatgg tcagtattct atgtggagat
3241 cttgcacctt gtaatcatca atacatccac caaaaatata taatgtacca tatatattaa
3301 tagtcaacaa atactcagat attctaaggt caatgccatt atttgattat accattttga
3361 gggtgaatat ggctaggcac tttagataag cctttttaaa attctttctg attttaaata
3421 atgcgtcaaa aaatgtgcag aaaatgtatt gcatcccttg atactgtcta acgaatagca
3481 cataactcgt attgtgaatc ctatgggtct tgaggcctgt agaaccaatc t
//