LOCUS AJ277832 2641 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for inducible T-cell co-stimulator (ICOS gene).
ACCESSION AJ277832
VERSION AJ277832.1
KEYWORDS ICOS gene; inducible T-cell co-stimulator.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2641)
AUTHORS Hutloff A.
JOURNAL Submitted (05-MAY-2000) to the INSDC. Hutloff A., Molecular
Immunology, Robert Koch-Institut, Nordufer 20, Berlin, 13353,
GERMANY.
REFERENCE 2
AUTHORS Hutloff A., Dittrich A.M., Beier K.C., Eljaschewitsch B., Kraft R.,
Anagnostopoulos I., Kroczek R.A.
TITLE ICOS is an inducible T-cell co-stimulator structurally and
functionally related to CD28
JOURNAL Nature 397(6716), 263-266(1999).
PUBMED 9930702
REFERENCE 3
AUTHORS Beier K.C., Hutloff A., Dittrich A.M., Heuck C., Rauch A.,
Buechner K., Ludewig B., Ochs H.D., Mages H.W., Kroczek R.A.
TITLE Induction, binding specificity and function of human ICOS
JOURNAL Eur. J. Immunol. 30(12), 3707-3717(2000).
PUBMED 11169414
FEATURES Location/Qualifiers
source 1..2641
/db_xref="H-InvDB:HIT000246404"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="MOLT-4V"
/cell_type="T-cell"
/db_xref="taxon:9606"
CDS 68..667
/gene="ICOS"
/product="inducible T-cell co-stimulator"
/function="immune response"
/db_xref="GOA:Q9Y6W8"
/db_xref="H-InvDB:HIT000246404.14"
/db_xref="HGNC:HGNC:5351"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR039943"
/db_xref="UniProtKB/Swiss-Prot:Q9Y6W8"
/citation=[2]
/protein_id="CAC06612.1"
/translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY
PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS
HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL
ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL"
sig_peptide 68..124
/gene="ICOS"
/citation=[2]
mat_peptide 125..664
/gene="ICOS"
/product="inducible T-cell co-stimulator"
/citation=[2]
BASE COUNT 743 a 556 c 516 g 826 t
ORIGIN
1 cgagagcctg aattcactgt cagctttgaa cactgaacgc gaggactgtt aactgtttct
61 ggcaaacatg aagtcaggcc tctggtattt ctttctcttc tgcttgcgca ttaaagtttt
121 aacaggagaa atcaatggtt ctgccaatta tgagatgttt atatttcaca acggaggtgt
181 acaaatttta tgcaaatatc ctgacattgt ccagcaattt aaaatgcagt tgctgaaagg
241 ggggcaaata ctctgcgatc tcactaagac aaaaggaagt ggaaacacag tgtccattaa
301 gagtctgaaa ttctgccatt ctcagttatc caacaacagt gtctcttttt ttctatacaa
361 cttggaccat tctcatgcca actattactt ctgcaaccta tcaatttttg atcctcctcc
421 ttttaaagta actcttacag gaggatattt gcatatttat gaatcacaac tttgttgcca
481 gctgaagttc tggttaccca taggatgtgc agcctttgtt gtagtctgca ttttgggatg
541 catacttatt tgttggctta caaaaaagaa gtattcatcc agtgtgcacg accctaacgg
601 tgaatacatg ttcatgagag cagtgaacac agccaaaaaa tctagactca cagatgtgac
661 cctataatat ggaactctgg cacccaggca tgaagcacgt tggccagttt tcctcaactt
721 gaagtgcaag attctcttat ttccgggacc acggagagtc tgacttaact acatacatct
781 tctgctggtg ttttgttcaa tctggaagaa tgactgtatc agtcaatggg gattttaaca
841 gactgccttg gtactgccga gtcctctcaa aacaaacacc ctcttgcaac cagctttgga
901 gaaagcccag ctcctgtgtg ctcactggga gtggaatccc tgtctccaca tctgctccta
961 gcagtgcatc agccagtaaa acaaacacat ttacaagaaa aatgttttaa agatgccagg
1021 ggtactgaat ctgcaaagca aatgagcagc caaggaccag catctgtccg catttcacta
1081 tcatactacc tcttctttct gtagggatga gaattcctct tttaatcagt caagggagat
1141 gcttcaaagc tggagctatt ttatttctga gatgttgatg tgaactgtac attagtacat
1201 actcagtact ctccttcaat tgctgaaccc cagttgacca ttttaccaag actttagatg
1261 ctttcttgtg ccctcaattt tctttttaaa aatacttcta catgactgct tgacagccca
1321 acagccactc tcaatagaga gctatgtctt acattctttc ctctgctgct caatagtttt
1381 atatatctat gcatacatat atacacacat atgtatataa aattcataat gaatatattt
1441 gcctatattc tccctacaag aatatttttg ctccagaaag acatgttctt ttctcaaatt
1501 cagttaaaat ggtttacttt gttcaagtta gtggtaggaa acattgcccg gaattgaaag
1561 caaatttatt ttattatcct attttctacc attatctatg ttttcatggt gctattaatt
1621 acaagtttag ttctttttgt agatcatatt aaaattgcaa acaaaatcat ctttaatggg
1681 ccagcattct catggggtag agcagaatat tcatttagcc tgaaagctgc agttactata
1741 ggttgctgtc agactatacc catggtgcct ctgggcttga caggtcaaaa tggtccccat
1801 cagcctggag cagccctcca gacctgggtg gaattccagg gttgagagac tcccctgagc
1861 cagaggccac taggtattct tgctcccaga ggctgaagtc accctgggaa tcacagtggt
1921 ctacctgcat tcataattcc aggatctgtg aagagcacat atgtgtcagg gcacaattcc
1981 ctctcataaa aaccacacag cctggaaatt ggccctggcc cttcaagata gccttcttta
2041 gaatatgatt tggctagaaa gattcttaaa tatgtggaat atgattattc ttagctggaa
2101 tattttctct acttcctgtc tgcatgccca aggcttctga agcagccaat gtcgatgcaa
2161 caacatttgt aactttaggt aaactgggat tatgttgtag tttaacattt tgtaactgtg
2221 tgcttatagt ttacaagtga gacccgatat gtcattatgc atacttatat tatcttaagc
2281 atgtgtaatg ctggatgtgt acagtacagt actgaacttg taatttgaat ctagtatggt
2341 gttctgtttt cagctgactt ggacaacctg actggctttg cacaggtgtt ccctgagttg
2401 tttgcaggtt tctgtgtgtg gggtggggta tggggaggag aaccttcatg gtggcccacc
2461 tggcctggtt gtccaagctg tgcctcgaca catcctcatc cccagcatgg gacacctcaa
2521 gatgaataat aattcacaaa atttctgtga aatcaaatcc agttttaaga ggagccactt
2581 atcaaagaga ttttaacagt agtaagaagg caaagaataa acatttgata ttcagcaact
2641 g
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