LOCUS AJ001697 2654 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for hurpin, clone R7-12.2.
ACCESSION AJ001697
VERSION AJ001697.2
KEYWORDS hurpin; PI13 gene; serine protease inhibitor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2654)
AUTHORS Abts H.F.
JOURNAL Submitted (29-SEP-1997) to the INSDC. Abts H.F., Dermatology,
Heinrich-Heine Universitaet, Duesseldorf, Moorenstr. 5,
Cytokinlabor, Geb. 11-80, 40225, GERMANY.
REMARK Revised by author 08-OCT-1999
REFERENCE 2
AUTHORS Abts H.F., Breuhahn K., Michel G., Koehrer K., Esser P., Ruzicka T.
TITLE Analysis of UVB-modulated gene expression in human keratinocytes by
mRNA differential display polymerase chain reaction
JOURNAL Photochem. Photobiol. 66(3), 363-367(1997).
PUBMED 9297979
REFERENCE 3
AUTHORS Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G.,
Ruzicka T.
TITLE Cloning and characterization of hurpin (protease inhibitor 13): A
new skin-specific, UV-repressible serine proteinase inhibitor of
the ovalbumin serpin family
JOURNAL J. Mol. Biol. 293(1), 29-39(1999).
PUBMED 10512713
FEATURES Location/Qualifiers
source 1..2654
/db_xref="H-InvDB:HIT000243891"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="HaCaT lambda II"
/clone="R7-12.2"
/cell_line="HaCaT"
/cell_type="keratinocyte"
/tissue_type="skin"
/db_xref="taxon:9606"
CDS 71..1246
/gene="PI13"
/product="hurpin"
/function="serine Protease Inhibitor"
/db_xref="GOA:Q9UIV8"
/db_xref="H-InvDB:HIT000243891.12"
/db_xref="HGNC:HGNC:8944"
/db_xref="InterPro:IPR000215"
/db_xref="InterPro:IPR023795"
/db_xref="InterPro:IPR023796"
/db_xref="InterPro:IPR036186"
/db_xref="InterPro:IPR042178"
/db_xref="InterPro:IPR042185"
/db_xref="UniProtKB/Swiss-Prot:Q9UIV8"
/protein_id="CAA04936.2"
/translation="MDSLGAVSTRLGFDLFKELKKTNDGNIFFSPVGILTAIGMVLLG
TRGATASQLEEVFHSEKETKSSRIKAEEKEVIENTEAVHQQFQKFLTEISKLTNDYEL
NITNRLFGEKTYLFLQKYLDYVEKYYHASLEPVDFVNAADESRKKINSWVESKTNEKI
KDLFPDGSISSSTKLVLVNMVYFKGQWDREFKKENTKEEKFWMNKSTSKSVQMMTQSH
SFSFTFLEDLQAKILGIPYKNNDLSMFVLLPNDIDGLEKIIDKISPEKLVEWTSPGHM
EERKVNLHLPRFEVEDGYDLEAVLAAMGMGDAFSEHKADYSGMSSGSGLYAQKFLHSS
FVAVTEEGTEAAAATGIGFTVTSAPGHENVHCNHPFLFFIRHNESNSILFFGRFSSP"
BASE COUNT 798 a 505 c 518 g 833 t
ORIGIN
1 cttatgcttc ctagttcgtt gcccagccac caccgtctct ccaaaaaccc gaggtctcgc
61 taaaatcatc atggattcac ttggcgccgt cagcactcga cttgggtttg atcttttcaa
121 agagctgaag aaaacaaatg atggcaacat cttcttttcc cctgtgggca tcttgactgc
181 aattggcatg gtcctcctgg ggacccgagg agccaccgct tcccagttgg aggaggtgtt
241 tcactctgaa aaagagacga agagctcaag aataaaggct gaagaaaaag aggtgattga
301 gaacacagaa gcagtacatc aacaattcca aaagtttttg actgaaataa gcaaactcac
361 taatgattat gaactgaaca taaccaacag gctgtttgga gaaaaaacat acctcttcct
421 tcaaaaatac ttagattatg ttgaaaaata ttatcatgca tctctggaac ctgttgattt
481 tgtaaatgca gccgatgaaa gtcgaaagaa gattaattcc tgggttgaaa gcaaaacaaa
541 tgaaaaaatc aaggacttgt tcccagatgg ctctattagt agctctacca agctggtgct
601 ggtgaacatg gtttatttta aagggcaatg ggacagggag tttaagaaag aaaatactaa
661 ggaagagaaa ttttggatga ataagagcac aagtaaatct gtacagatga tgacacagag
721 ccattccttt agcttcactt tcctggagga cttgcaggcc aaaattctag ggattccata
781 taaaaacaac gacctaagca tgtttgtgct tctgcccaac gacatcgatg gcctggagaa
841 gataatagat aaaataagtc ctgagaaatt ggtagagtgg actagtccag ggcatatgga
901 agaaagaaag gtgaatctgc acttgccccg gtttgaggtg gaggacggtt acgatctaga
961 ggcggtcctg gctgccatgg ggatgggcga tgccttcagt gagcacaaag ccgactactc
1021 gggaatgtcg tcaggctccg ggttgtacgc ccagaagttc ctgcacagtt cctttgtggc
1081 agtaactgag gaaggcaccg aggctgcagc tgccaccggc ataggcttta ctgtcacatc
1141 cgccccaggt catgaaaatg ttcactgcaa tcatcccttc ctgttcttca tcaggcacaa
1201 tgaatccaac agcatcctct tcttcggcag attttcttct ccttaagatg atcgttgcca
1261 tggcattgct gcttttagca aaaaacaact accagtgtta ctcatatgat tatgaaaatc
1321 gtccattctt ttaaatgttg tctcacttgc atttccagtc ttggccatca aatcaatgat
1381 ttaatgactc caataatgtg tgtgtttata accatcctcg aaagtgaaat gtcctttttt
1441 ttgtgccatg cgtaaggtga gtcaaaccaa acctcattga taatctcccc tttggtttcc
1501 tttgaaagta aattggtatc ttgtagtttt gtgcacacga aaggagagaa agtttctcca
1561 gtaaagagta cgaactagta attttggggg gtctctctaa ttctggtatt ttgacatgtt
1621 ataatacgca agtaaaataa aacaatagtt tactcagctc atgttactat tccccaacag
1681 atattgtggc aaatcacaca taggaaagag gatttgggaa tacagtagca aaacataaat
1741 taaaactcaa atgcccagga caaaataaaa caatatacca gatggagagg atgcccgtat
1801 tttcatcttc cattctaaca ttatccattg ttagatgcat aagcattttg atattgtgta
1861 ataaatgtgg tatttgagaa gataaatgat gtagttgatc agtaatcctc ctctatcacc
1921 tttttagact ttgtaaggta aatatttgga ctaactttta gaaaagtttc cctttttttc
1981 tccatttaca tttttctggt tttttttttt ttttttgagt gaggtacgag tattaccaaa
2041 tgatattttc tgaagatgct ttttggaaag ctctgaatct atacctaatg ctcttaatta
2101 ttggcttgtt tcattttttt cctccagttt ttaacaagat cacataactg gcttattttt
2161 aacagctttg tcaaactaca atttacatgc cgtaaaatgt acacactgta attttataat
2221 tcattgactt ttagtaaatt ttctagcgtt atgcatcgcc acaatccagt tttagaatat
2281 ttccatgacc ctaagaagtt tcctcatgtc tattaatatt cccaatccta ggcaccactg
2341 agttgttttc tgtctttata agtttttctt tctacatctt atataaatgg aatcataata
2401 catgtagtat tttgtgtctg gcgtcttgca cttagcatgg tgttcttgag gttcatctgt
2461 tgtagtatgt attgatactt aggatttttt tattgccgaa tactattcca ttgcatggaa
2521 aagacctatt ttatttctag gttcaccagt tgagggacat ttggattgtt cccacttctt
2581 gggctgttag gaataatgtt gctctgaaca tgtaaataaa gatctttgtg ttcaaaaaaa
2641 aaaaaaaaaa aaaa
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