LOCUS       AF360991                 776 bp    mRNA    linear   HUM 14-MAY-2001
DEFINITION  Homo sapiens mannan-binding lectin MBL precursor (MBL) mRNA,
            complete cds.
ACCESSION   AF360991
VERSION     AF360991.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Chen,Z., Zhu,X. and Xie,P.
  TITLE     Cloning and sequencing of mannan-binding lectin cDNA of Chinese
  JOURNAL   Mianyixue Zazhi 15, 83-86 (1999)
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Chen,Z., Zhu,X. and Xie,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-MAR-2001) Immunology, First Military Medical
            University, Tonghe, Guangzhou, Guangdong 510515, P.R. of China
FEATURES             Location/Qualifiers
     source          1..776
                     /db_xref="H-InvDB:HIT000078350"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.2-q21"
                     /cell_type="hepatocyte"
                     /tissue_type="liver"
     gene            1..776
                     /gene="MBL"
     CDS             17..763
                     /gene="MBL"
                     /note="activates complement system; serum protein"
                     /codon_start=1
                     /product="mannan-binding lectin MBL precursor"
                     /protein_id="AAK52907.1"
                     /db_xref="GI:14030460"
                     /translation="MSLFPSLPLLLLSMVAASYSETVACEDAQKTCPAVIACSSPGIN
                     GFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPD
                     GDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQA
                     SVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGS
                     DEDCVLLLKNGQWNDVPCSTSHLAVCEFPI"
     sig_peptide     17..76
                     /gene="MBL"
     mat_peptide     77..760
                     /gene="MBL"
                     /product="mannan-binding lectin MBL"
     variation       86
                     /gene="MBL"
                     /note="compared to Homo sapiens mannan-binding lectin
                     encoded by GenBank Accession Number X15422; Ala to Thr
                     substitution"
                     /replace="a"
     variation       571
                     /gene="MBL"
                     /note="compared to Homo sapiens mannan-binding lectin
                     encoded by GenBank Accession Number X15422; does not alter
                     sequence of predicted protein"
                     /replace="c"
BASE COUNT          210 a          193 c          213 g          160 t
ORIGIN      
        1 cacaccaagg gagaccatgt ccctgtttcc atcactccct ctccttctcc tgagtatggt
       61 ggcagcgtct tactcagaaa ctgtggcctg tgaggatgcc caaaagacct gccctgcagt
      121 gattgcctgt agctctccag gcatcaacgg cttcccaggc aaagatgggc gtgatggcac
      181 caagggagaa aagggggaac caggccaagg gctcagaggc ttacagggcc cccctggaaa
      241 gttggggcct ccaggaaatc cagggccttc tgggtcacca ggaccaaagg gccaaaaagg
      301 agaccctgga aaaagtccgg atggtgatag tagcctggct gcctcagaaa gaaaagctct
      361 gcaaacagaa atggcacgta tcaaaaagtg gctgaccttc tctctgggca aacaagttgg
      421 gaacaagttc ttcctgacca atggtgaaat aatgaccttt gaaaaagtga aggccttgtg
      481 tgtcaagttc caggcctctg tggccacccc caggaatgct gcagagaatg gagccattca
      541 gaatctcatc aaggaggaag ccttcctggg tatcactgat gagaagacag aagggcagtt
      601 tgtggatctg acaggaaata gactgaccta cacaaactgg aacgagggtg aacccaacaa
      661 tgctggttct gatgaagatt gtgtattgct actgaaaaat ggccagtgga atgacgtccc
      721 ctgctccacc tcccatctgg ccgtctgtga gttccctatc tgaagggtct gtgagt
//