LOCUS AF352582 4492 bp mRNA linear HUM 15-MAR-2001
DEFINITION Homo sapiens ATP-binding cassette transporter MRP8 mRNA, complete
cds.
ACCESSION AF352582
VERSION AF352582.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4492)
AUTHORS Bera,T.K., Lee,B.K., Lee,S., Vincent,J. and Pastan,I.H.
TITLE MRP8, a new member of the human ATP-binding cassette (ABC)
transporter superfamily which has restricted expression in few
tissues
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 4492)
AUTHORS Bera,T.K., Lee,B.K., Lee,S., Vincent,J. and Pastan,I.H.
TITLE Direct Submission
JOURNAL Submitted (23-FEB-2001) Laboratory of Molecular Biology, National
Cancer Institute, NIH, 37 Convent Dr., Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..4492
/db_xref="H-InvDB:HIT000078241"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q12.1"
/tissue_type="breast"
CDS 100..4248
/note="ABC transporter"
/codon_start=1
/product="ATP-binding cassette transporter MRP8"
/protein_id="AAK19755.1"
/translation="MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWS
QQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTP
LMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQR
TRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSL
SFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVC
YGPLVLITCASLVICSISSYFIIGYTAFIAILCYPLVFPLEVFMTRMAVKAQHHTSEV
SDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI
IPAVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMR
FKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMT
RPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEG
SVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM
TEIGERGPNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR
GKTVVQVTHQLQYLEFCGQVILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSD
MLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQ
AAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADN
PQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTI
PIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVI
CFIYYMMFKEAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTD
AQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLA
SSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDY
HMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV
DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISK
FPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI
REAFQGCTVLVIAHRVTTVLNCDRILVMGNGKVVEFDRPEVLRKKPGSLFAALMATAT
SSLR"
BASE COUNT 1073 a 1158 c 1197 g 1064 t
ORIGIN
1 gtcacctgga tggtgtaaag gaaacaagag acaggaacag agcccctcat ctcacctctg
61 ggctaccata cagaaaagca gaattggcag gaactgaaaa tgactaggaa gaggacatac
121 tgggtgccca actcttctgg tggcctcgtg aatcgtggca tcgacatagg cgatgacatg
181 gtttcaggac ttatttataa aacctatact ctccaagatg gcccctggag tcagcaagag
241 agaaatcctg aggctccagg gagggcagct gtcccaccgt gggggaagta tgatgctgcc
301 ttgagaacca tgattccctt ccgtcccaag ccgaggtttc ctgcccccca gcccctggac
361 aatgctggcc tgttctccta cctcaccgtg tcatggctca ccccgctcat gatccaaagc
421 ttacggagtc gcttagatga gaacaccatc cctccactgt cagtccatga tgcctcagac
481 aaaaatgtcc aaaggcttca ccgcctttgg gaagaagaag tctcaaggcg agggattgaa
541 aaagcttcag tgcttctggt gatgctgagg ttccagagaa caaggttgat tttcgatgca
601 cttctgggca tctgcttctg cattgccagt gtactcgggc caatattgat tataccaaag
661 atcctggaat attcagaaga gcagttgggg aatgttgtcc atggagtggg actctgcttt
721 gccctttttc tctccgaatg tgtgaagtct ctgagtttct cctccagttg gatcatcaac
781 caacgcacag ccatcaggtt ccgagcagct gtttcctcct ttgcctttga gaagctcatc
841 caatttaagt ctgtaataca catcacctca ggagaggcca tcagcttctt caccggtgat
901 gtaaactacc tgtttgaagg ggtgtgctat ggacccctag tactgatcac ctgcgcatcg
961 ctggtcatct gcagcatttc ttcctacttc attattggat acactgcatt tattgccatc
1021 ttatgctatc ccctggtttt cccactggag gtattcatga caagaatggc tgtgaaggct
1081 cagcatcaca catctgaggt cagcgaccag cgcatccgtg tgaccagtga agttctcact
1141 tgcattaagc tgattaaaat gtacacatgg gagaaaccat ttgcaaaaat cattgaagac
1201 ctaagaagga aggaaaggaa gctattggag aagtgcgggc ttgtccagag cctgacaagt
1261 ataaccttgt tcatcatccc cgcagtggcc acagcggtct gggttctcat ccacacatcc
1321 ttaaagctga aactcacagc gtcaatggcc ttcagcatgc tagcctcctt gaatctcctt
1381 cggctgtcag tgttctttgt gcctattgca gtcaaaggtc tcacgaattc caagtctgca
1441 gtgatgaggt tcaagaagtt tttcctccag gagagccctg ttttctatgt ccagacatta
1501 caagacccca gcaaagctct ggtctttgag gaggccacct tgtcatggca acagacctgt
1561 cccgggatcg tcaatggggc actggagctg gagaggaacg ggcatgcttc tgaggggatg
1621 accaggccta gagatgccct cgggccagag gaagaaggga acagcctggg cccagagttg
1681 cacaagatca acctggtggt gtccaagggg atgatgttag gggtctgcgg caacacgggg
1741 agtggtaaga gcagcctgtt gtcagccatc ctggaggaga tgcacttgct cgagggctcg
1801 gtgggggtgc agggaagcct ggcctatgtc ccccagcagg cctggatcgt cagcgggaac
1861 atcagggaga acatcctcat gggaggcgca tatgacaagg cccgatacct ccaggtgctc
1921 cactgctgct ccctgaatcg ggacctggaa cttctgccct ttggagacat gacagagatt
1981 ggagagcggg gccccaacct ctctgggggg cagaaacaga ggatcagcct ggcccgcgcc
2041 gtctattccg accgtcagat ctacctgctg gacgaccccc tgtctgctgt ggacgcccac
2101 gtggggaagc acatttttga ggagtgcatt aagaagacac tcagggggaa gacggtcgtc
2161 caggtgaccc accagctgca gtacttagaa ttttgtggcc aggtcatttt gttggaaaat
2221 gggaaaatct gtgaaaatgg aactcacagt gagttaatgc agaaaaaggg gaaatatgcc
2281 caacttatcc agaagatgca caaggaagcc acttcggaca tgttgcagga cacagcaaag
2341 atagcagaga agccaaaggt agaaagtcag gctctggcca cctccctgga agagtctctc
2401 aacggaaatg ctgtgccgga gcatcagctc acacaggagg aggagatgga agaaggctcc
2461 ttgagttgga gggtctacca ccactacatc caggcagctg gaggttacat ggtctcttgc
2521 ataattttct tctttgtggt gctgatcgtc ttcttaacga tcttcagctt ctggtggctg
2581 agctactggt tggagcaggg ctcggggacc aatagcagcc gagagagcaa tggaaccatg
2641 gcagacctgg gcaacattgc agacaatcct caactgtcct tctaccagct ggtgtacggg
2701 ctcaacgccc tgctcctcat ctgtgtgggg gtctgctcct cagggatttt caccaaggtc
2761 acgaggaagg catccacggc cctgcacaac aagctcttca acaaggtttt ccgctgcccc
2821 atgagtttct ttgacaccat cccaataggc cggcttttga actgcttcgc aggggacttg
2881 gaacagctgg accagctctt gcccatcttt tcagagcagt tcctggtcct gtccttaatg
2941 gtgatcgccg tcctgttgat tgtcagtgtg ctgtctccat atatcctgtt aatgggagcc
3001 ataatcatgg ttatttgctt catttattat atgatgttca aggaggccat cggtgtgttc
3061 aagagactgg agaactatag ccggtctcct ttattctccc acatcctcaa ttctctgcaa
3121 ggcctgagct ccatccatgt ctatggaaaa actgaagact tcatcagcca gtttaagagg
3181 ctgactgatg cgcagaataa ctacctgctg ttgtttctat cttccacacg atggatggca
3241 ttgaggctgg agatcatgac caaccttgtg accttggccg ttgccctgtt cgtggctttt
3301 ggcatttcct ccacccccta ctcctttaaa gtcatggctg tcaacatcgt gctgcagctg
3361 gcgtccagct tccaggccac tgcccggatt ggcttggaga cagaggcaca gttcacggct
3421 gtagagagga tactgcagta catgaagatg tgtgtctcgg aagctccttt acacatggaa
3481 ggcacaagtt gtccccaggg gtggccacag catggggaaa tcatatttca ggattatcac
3541 atgaaataca gagacaacac acccaccgtg cttcacggca tcaacctgac catccgcggc
3601 cacgaagtgg tgggcatcgt gggaaggacg ggctctggga agtcctcctt gggcatggct
3661 ctcttccgcc tggtggagcc catggcaggc cggattctca ttgacggcgt ggacatttgc
3721 agcatcggcc tggaggactt gcggtccaag ctctcagtga tccctcaaga tccagtgctg
3781 ctctcaggaa ccatcagatt caacctagat ccctttgacc gtcacaccga ccagcagatc
3841 tgggatgcct tggagaggac attcctgacc aaggccatct caaagttccc caaaaagctg
3901 catacagatg tggtggaaaa cggtggaaac ttctctgtgg gggagaggca gctgctctgc
3961 attgccaggg ctgtgcttcg caactccaag atcatcctta tcgatgaagc cacagcctcc
4021 attgacatgg agacagacac cctgatccag cgcacaatcc gtgaagcctt ccagggctgc
4081 accgtgctcg tcattgccca ccgtgtcacc actgtgctga actgtgaccg catcctggtt
4141 atgggcaatg ggaaggtggt agaatttgat cggccggagg tactgcggaa gaagcctggg
4201 tcattgttcg cagccctcat ggccacagcc acttcttcac tgagataagg agatgtggag
4261 acttcatgga ggctggcagc tgagctcaga ggttcacaca gctgcagctt cgaggcccac
4321 agtctgcgac cttcttgttt ggagatgaga acttctcctg gaagcagggg taaatgtagg
4381 gggggtgggg attgctggat ggaaaccctg gaataggcta cttgatggct ctcaagacct
4441 tagaacccca gaaccatcta agacatggga ttcagtgatc atgtggttct cc
//