LOCUS       AF135026                8622 bp    DNA     linear   HUM 24-SEP-2001
DEFINITION  Homo sapiens kallikrein-like protein 3 (KLK9) gene, complete cds,
            alternatively spliced.
ACCESSION   AF135026
VERSION     AF135026.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8622)
  AUTHORS   Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
  TITLE     Identification of novel human kallikrein-like genes on chromosome
            19q13.3-q13.4
  JOURNAL   Anticancer Res. 19 (4B), 2843-2852 (1999)
   PUBMED   10652563
REFERENCE   2  (bases 1 to 8622)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol. Metab. 11 (2), 54-60 (2000)
   PUBMED   10675891
REFERENCE   3  (bases 1 to 8622)
  AUTHORS   Yousef,G.M. and Diamandis,E.P.
  TITLE     The expanded human kallikrein gene family: locus characterization
            and molecular cloning of a new member, KLK-L3 (KLK9)
  JOURNAL   Genomics 65 (2), 184-194 (2000)
   PUBMED   10783266
REFERENCE   4  (bases 1 to 8622)
  AUTHORS   Yousef,G.M., Grass,L. and Diamandis,E.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-MAR-1999) Pathology and Laboratory Medicine, Mount
            Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5,
            Canada
FEATURES             Location/Qualifiers
     source          1..8622
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.3-q13.4"
     gene            1501..8622
                     /gene="KLK9"
     mRNA            join(1501..1630,1796..1952,4412..4677,7295..7431,
                     7875..8622)
                     /gene="KLK9"
                     /product="kallikrein-like protein 3"
     mRNA            join(1501..1630,1796..1952,4412..4571,7295..7431,
                     7875..8622)
                     /gene="KLK9"
                     /product="kallikrein-like protein 3 splice variant 1"
     CDS             join(1588..1630,1796..1952,4412..4571,7295..7431,
                     7875..8082)
                     /gene="KLK9"
                     /note="KLK-L3; alternatively spliced"
                     /codon_start=1
                     /product="kallikrein-like protein 3 splice variant 1"
                     /protein_id="AAG22845.1"
                     /db_xref="GI:10765093"
                     /translation="MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLT
                     RLFCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKD
                     LSANDHNDDIMLIRLPRQRCFQSHCSVPTSASWRTNSVTGHTLDTSRTACSVRACGRG
                     AEVPARVTLGAPWFAMEPWQAWCLGVLSPAPDPGAPQSTPAYATTLTGSKKSWRTEPA
                     RHGGTLEDQERPKGTG"
     CDS             join(1588..1630,1796..1952,4412..4677,7295..7431,
                     7875..8024)
                     /gene="KLK9"
                     /note="KLK-L3; alternatively spliced"
                     /codon_start=1
                     /product="kallikrein-like protein 3"
                     /protein_id="AAD26427.2"
                     /db_xref="GI:5919239"
                     /translation="MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLT
                     RLFCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKD
                     LSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTCVSPGMQCLISGWGAVSSPKALFPV
                     TLQCANISILENKLCHWAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVV
                     SGGAEPCSRPRRPAVYTSVCHYLDWIQEIMEN"
BASE COUNT         2014 a         2203 c         2144 g         2261 t
ORIGIN      
        1 cttgaaccca ggaggcagag gttgcagtga gctgagatcg cgccactgta cttcagcctg
       61 ggtgtcagag caatactccg ttttggaaaa caaacaaaca aacaaacaaa caaaaaacag
      121 atggagcaac tgagagaggt cttgtgactt gcccaaagtc acacacctca tcactaatca
      181 cacctaatca ttgagatttg gacacacatg gttcagttcc agagtccatg ctccaaacca
      241 tgacgacaca gtgagagaac attcaagggg agcccagacc cagcttcata accaggcctg
      301 tgagcaggag aaagtggaag ggatcgtaag tgcccagggg aggcaaagat ggactctgcc
      361 tgaggatctc agagatttcc tggaggaggg agaattgagg ttgggtgttg aaggatgagt
      421 gggagttcac caggaaaaga aggatatgga gaaagacatt cactcattca atgaacatct
      481 cctgaggact tctgcaagcc ctgttccgcc tggaacgggg tgatgctggg acacagagat
      541 gagtcagacc tgggcccagc cctccagaag ctgtccacct ggtgagaagg aatgatgagg
      601 agagaggcag ggaggatggg gtgatggaag ggacaatggg gtggggggca gggagatgga
      661 tgaaaaaaat atatagcaaa tgttctcagg atttggcaaa gatcaggatg tattaagaga
      721 gagcacaggg cacttgctac ctggaaggtt gggcacctgg gtccttgggt ggtggagccg
      781 tggggaaggg ggcaggttat gacaagagtg ggttaatcca gatggaacca gatttctcaa
      841 cattctagga gagggccttg tccttgtggg aagaggccca aatccccagg gcagggaagg
      901 ttctgcaagg tgtgtaaacc tgtgcagctg cctgtggtct ctgcctcact ccacctggat
      961 ttccctcaat ctttcccgtg ttctgtctcc tcctcccact cctcctctca tcttgggtcc
     1021 ttctgtgcct gtacctccct ctctttgtat cttttgctct tgtgtctgag tcctgactct
     1081 gtcttccacc cctcgcctcc tttctgggtg gtccccctgc acatccctcc agcctgccgt
     1141 gggaggttgg tctctgcaca ccactgcttt atccaaaata aacctgctgc accccaggac
     1201 cttaggcttc aaggatctcc ctccttttcc aggacacaaa agattctgta tcttgtagcc
     1261 taaggtgatg aggaatgagg tctcccactc tgaagacccc agaggaggtg cccacaacct
     1321 ctccacaccc ccagcactcc tcctccattc agtcaagctc tggcccagca agccgccagt
     1381 tcatcccaaa aggggggtcc ccctgcactt acctcctctc ccaaggcccc tgtcacagcc
     1441 ccagggcttc cccctccccc aggtacattt cccaaccccg attaatcaca ggggcggccc
     1501 catggaggag gaaggagatg gcatggctta ccataaagaa gcactggacg ccgggtgcac
     1561 gttccaggat ccaggtgccc aggggtcatg aagctgggac tcctctgtgc tctgctctct
     1621 ctgctggcag gtgaggctcc caggctggct gccccttcac ggctgtacta aggtcacctt
     1681 gctcttccct cccatcccag gcttctgcct cctgccctct aggcttctca gcatcctctc
     1741 cctgccctcc cagcctgctc ttcgctgacc cctttgtccc tcatccccac cccagggcat
     1801 ggctgggcag acacccgtgc catcggggcc gaggaatgtc gccccaactc ccagccttgg
     1861 caggccggcc tcttccacct tactcggctc ttctgtgggg cgaccctcat cagtgaccgc
     1921 tggctgctca cagctgccca ctgccgcaag ccgtgagtga cccaggctgg ccatgctggg
     1981 gagggacaga ggctgggggt caggagaggg tgaggggtgc tttaggccag aagtgcggag
     2041 cctccacttc tgataccaca agttcaactc ttagaagtag gaagggtagc ctcccaaatc
     2101 ctaaaattct agagaccagc aatatctcat ttgagaagtc taagattcga aacttaggct
     2161 cttcgaatcc gagactgacc cagagaaatc cagaatcgta gaatcctaaa atcttgaatt
     2221 tatgaaattc tgcaatagcc tcagcaaatt ttagaatcat agattcgcag actattagaa
     2281 tcttagcagt ctgggtcagc actgcccaga ggaattatga tgccagccac atgtgtaagt
     2341 ttaaatttct ggtggacaca tttaaaaaat aaggaatgag taaaattaat tctaatagat
     2401 ttaacttgac atacccaaaa acttattttg acatgtaatc aatttttaaa tacgtatgaa
     2461 cgatacagtt tacttttgtt ttggtactaa gcctttgaaa tctgttctgt attttacaca
     2521 catagcctgt tacaaaatgg actagccaca tttcaagtgt tcaatagcca taatggctag
     2581 tgtgatccta gaatcttaaa ttcagagctt tctagattca ttgaatattg aaactcacag
     2641 tactagaatc tttgattcac agtatcctag aatattgaga ttcagataat tctgtagtct
     2701 taaactattt gaatcccaga ctcttaaatt tctaaggtta tagatttata gaatgatgac
     2761 attctagtct ttcttttttt tttttttttt tttttttgag acagagtctc cctctatctc
     2821 ccaggctgga gtgcagtggc acaatctcag ctcactgcaa cctctgcctc tcgggttcaa
     2881 gcaattctcc tgcctcagcc tcctgagtag ctgggattac aggtatgcac caccatgcca
     2941 ggctattttt tttttttttt tttttttagt agagacgggg gtttcaccat attggccagg
     3001 ctggtcttga actcctgacc ttgtgatctg cccgcctcgg cctcccaaag tgctgggatt
     3061 acaggcgtga gccaccgcgc ccagccaaaa ttctagtctt tttgtcctag aacattaaaa
     3121 ttctatgttc aaatcttaga tttaattcag ataatgttag aatcctggag tttttttgat
     3181 ccaggggaat ctggaatgtt agaatcttgg attcataaaa ctctaaacct tgagcctcta
     3241 gattctagaa tcatggataa tagtgtgtcg gaatctgaga attctagaat cttaggttct
     3301 gggcattcta atagtatcct ggaatccacc tgatgcagga atcctctctc cattgcctct
     3361 gaaaagtgac catccatact gttccaattt tcttccctcc atgagtaaag cactgattgt
     3421 ggtaagagat gctgtgtggg aatttcccat catgcattgc tccatgatgg aacctccttt
     3481 aacttaagcc tatacatcag actgggagaa cgatgttcag atttcagccg aaagtgaagc
     3541 aggagaaatg cagagatatg aaggtggaag agagtgagag gcaggggaag ggtaggggga
     3601 tgaagggatg taggggtgag gactactttt ccagatccag agccaagaca gcaagaatga
     3661 cagagagaga cagacacaga tgtttctggt tccccaaccc tgaattcgca gtcattagcc
     3721 tgctgcctaa tgtcagaggt cagaggctgg ggaatggact tgtcatcccc gaaaggatcc
     3781 cagctgtcta gggcatggac cagaaatgaa acaagtgcgc tgagactgtg gtgagggctt
     3841 aaggttagac accaggaaga catgcattga agggtgaagg atatgataga caggaaaagc
     3901 tgaggccaga gatgaccccc aatttgggga ttttccatat cccatcccct ttcatacaca
     3961 cgcacacgta tacacacaca ccacttagac atacagagcc gctcccacag aagccaccag
     4021 acctgtgggg gcaggggtgg ggcggttgtt atgtggtagg tggggtcccc cgtgcccaca
     4081 ccgttcctag ggacccaagt caccaccaag gctccaggtg agtagggagg aaggtggctc
     4141 actcagcctg ggactaggag cgggggcttt gtggggagag ctacaaagat ggagacacac
     4201 aaaacatcag agtggggacc agggacccag aggaggtgtg tgcctcgctt aaaatcacag
     4261 taccctgggc cagacataga tgatgagggt gcagagaggg tgtgtggctt gcagagggtc
     4321 acacagcacc ctgatggaca ggaaaagagg gctggggctg aaaggacttt tacctttccc
     4381 ccagcttgac ctctgaggcc tgtcccagca ggtatctgtg ggtccgcctt ggagagcacc
     4441 acctctggaa atgggagggt ccggagcagc tgttccgggt tacggacttc ttcccccacc
     4501 ctggcttcaa caaggacctc agcgccaatg accacaatga tgacatcatg ctgatccgcc
     4561 tgcccaggca ggcacgtctg agtcctgctg tgcagcccct caacctcagc cagacctgtg
     4621 tctccccagg catgcagtgt ctcatctcag gctggggggc cgtgtccagc cccaagggta
     4681 tgacctggcc cagaactctc tctgaaactt gctccctcac ccctctgtct ctgccttttc
     4741 atctctgtct tctccttttc tctctcctct ctctctctgt cagtctatct atctgccaat
     4801 cgatatattt aaccaaatat aagatgctag catttttaag atgtgccatt atttcatgaa
     4861 ctgcgaagaa gtggaagaag gaggaggagg agaagaaaaa aaggaggagg aggaaagatc
     4921 ccattagatc ccattgatta tataacacca ttttctggaa gacacattct aatttcagag
     4981 tgtttgtttg tttgtttgtt tgtttgtttt tgagacaggg tctcgctttg ttgctcaggc
     5041 tggagtgcag cggtgtgatc acggctcatt gcagctttga actcctgggc tcaagtgatc
     5101 ctctcgcctc aacctcccaa gtagctggga ttacagatat gcaccaccac atcccacacc
     5161 ggggtcattt ttttattatt tattattatt attattatta tctttttttt tgtattttta
     5221 gtagagacag aggtttcacc atattggcca ggctggtctc aaattcctga cctggtgatc
     5281 tgcccgcctt ggactcccaa agtgctggga aaacaggcat gagccactgc acccagccaa
     5341 aattctagtc ttttttaaat ctagtcatat cttagattta attcagataa tgttagaatc
     5401 ctggagtttt ttgatccagg ggaatctgga atgttagaat cttggattca taaaactcta
     5461 aacgttgagc ctctagattc tagaatcatg gatactagtg tgtcagaatc tgagaattct
     5521 agaatcttag attctgggca ttctaatagt atcctggaat ccacctgatg caggaatcct
     5581 ctctccattg cctctgaaaa gtgaccatcc atactgttcc aattttcttc cctccatgaa
     5641 taaagcactg attctggtaa aagatgctgg gtgggaattt cccatcatgc attgctccat
     5701 gatgggacct cctttaactt aagccttatg ctaaaaattt ttattatttt tagcaaagat
     5761 gaggtcttgc tatgttgtcc aggctagtct caaactcctg gcctcccaaa gtgctgagat
     5821 tacaagtgtg agccactgta cctggcccag agatgtttaa atgtgaaatg cgttcatctt
     5881 agaatgggaa taagaccatg tctctcagag tcacggatca ctgacccatt agccaaattg
     5941 ggtcagtgga ttggaaaaac agtctgaatt tgttgctgcc aatatctaaa acttggaaag
     6001 ttttatacaa aagccaggtt tctggattca cctgaaaaag tttgaagaac tcacattccc
     6061 aaaatagcaa gcattgggct gagtcaatgg aggctgcccc cttcagccaa gataagttct
     6121 ctgattcact ccaatggacc caaatggctc ctgtctccct gcacagcccc cgtccccgac
     6181 ttctgtttac caattctgtt tatcatatcc cttgatgcat cggagcctgc acccatgtct
     6241 tatatagatg cacatgtgta ttatatatcc atatccacat ctatactgac tacactgtat
     6301 ctggtatctc tgtctatgtc tctgtctcca tcagtgacca tcttcctgca aatctctttc
     6361 cttttatctc actgccttca ttccacccct tgaggtctgg gtctttttct atttcttttt
     6421 tttttttttt taagagactg agtcttgctc ttgttgccca ggctggagtg cagtggtgtg
     6481 atctcggctc actgcaacct ccacctcctg ggttttaagt gatcctcctg cctcagcctc
     6541 ccgagtagct gggactacag gtgtgcaaca gcatgcccag ctgatttttt gtattttcag
     6601 tagagacgga gtttcaccat gttggccagg atggtctcaa tctcttgacc ttgtgatccg
     6661 cccgcctcag cctcccaaag tgctagggag ttatatatgc atctcctctt atctcttggc
     6721 tctctgcatg catctttctg tttctcttcc ttcctttctt tttttttttt tttttttttt
     6781 tttttttttt ttttttgaga cggagtcttg ctctgtctcc caggctggag tgcagtgacc
     6841 agtctcggct cactgcaacc tccacctccc aggttcaagt gattctcgtg cctcagcctc
     6901 ccgagtagct gggattacag gcgcctgcca ccatgcctgg ctaatttttg tatatttagc
     6961 agagatgggg tttcaccatg ttggctgggc tggtctcaaa ctcctgacct caagcgatcc
     7021 gccggcctcg gcctccaaaa cactgggatt acaggcatga gccacggtgc ccggccagcc
     7081 tctctctcta cttggccctc ttcctccttg tctccatttg tttctcttgt gtgctatgac
     7141 tgtctgtctg tcactgtctc ttgtctctat ctttgagagt cctaaatgtg gctccattgg
     7201 tcctttggaa aagctgcagg gaggactcag ggcagtgggg tgctgagtgt gttggagaca
     7261 gttgcagatc cttgacagtt ctcttccctg acagcgctgt ttccagtcac actgcagtgt
     7321 gccaacatca gcatcctgga gaacaaactc tgtcactggg cataccctgg acacatctcg
     7381 gacagcatgc tctgtgcggg cctgtgggag gggggccgag gttcctgcca ggtgagacct
     7441 tactctgggg aaaatgaggc tgtcctgcca agttttctag gatttagggg agcagagggg
     7501 tcggccccca gccttcctgg gtcaaaatga gaaggagact gggatacctg gttcctggga
     7561 gaggacggga ccagggcctg gactccttag tgtaaaagag aaaaggtctg gaggtccaga
     7621 cttctggatc tacaggagga gtgggctggg cgtccagagt ctgagtcctc ggggaggagg
     7681 aggttaggtc ctgcggggag gtgggccctc tgagctttta ctcctgggtc tgaggaagaa
     7741 gaggctggag atggaggact ctcggatgtt ggaggaggaa ggggctgggg cctttctggg
     7801 agggaggaag tggcccgtgt aattgtcatg aacagagtgg cctaacagtt cctctgccct
     7861 tctctcgcgt acagggtgac tctgggggcc ccctggtttg caatggaacc ttggcaggcg
     7921 tggtgtctgg gggtgctgag ccctgctcca gaccccggcg ccccgcagtc tacaccagcg
     7981 tatgccacta ccttgactgg atccaagaaa tcatggagaa ctgagcccgc gcgccacggg
     8041 ggcaccttgg aagaccaaga gaggccgaag ggcacggggt agggggttct cgtagggtcc
     8101 cagcctcaat ggttcccgcc ctggacctcc agctgccctg actcccctct ggacactaag
     8161 actccgcccc tgaggctccg ccccctcacg aggtcaagca agacacagtc gcgccccctc
     8221 ggaacggagc agggacacgc ccttcagagc ccgtctctat gacgtcaccg acagccatca
     8281 cctccttctt ggaacagcac agcctgtggc tccgccccaa ggaaccactt acacaaaata
     8341 gctccgcccc tcggaacttt gcccagtggg acttcccctc gggactccac cccttgtggc
     8401 cccgcctcct tcaccagaga tctcgcccct cgtgatgtca ggggcgcagt agctccgccc
     8461 acgtggagct cgggcggtgt agagctcagc cccttgtggc cccgtcctgg gcgtgtgctg
     8521 ggtttgaatc ctggcggaga cctgggggga aattgaggga gggtctggat acctttagag
     8581 ccaatgcaac ggatgatttt tcagtaaacg cgggaaacct ca
//