LOCUS AF125042 2113 bp mRNA linear HUM 14-OCT-1999
DEFINITION Homo sapiens bisphosphate 3'-nucleotidase mRNA, complete cds.
ACCESSION AF125042
VERSION AF125042.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2113)
AUTHORS Spiegelberg,B.D., Xiong,J.P., Smith,J.J., Gu,R.F. and York,J.D.
TITLE Cloning and characterization of a mammalian lithium-sensitive
bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
JOURNAL J. Biol. Chem. 274 (19), 13619-13628 (1999)
PUBMED 10224133
REFERENCE 2 (bases 1 to 2113)
AUTHORS Spiegelberg,B.D. and York,J.D.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-1999) Pharmacology/Cancer Biology and
Biochemistry, Duke University, Duke Univ. Medical Center, Box 3813,
Durham, NC 27708, USA
FEATURES Location/Qualifiers
source 1..2113
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 114..1040
/function="3' phosphomonoesterase activity on PAP and
PAPS"
/note="BPntase; lithium-sensitive nucleotidase; inhibited
by inositol 1,4-bisphosphate; complements yeast met22
disruption"
/codon_start=1
/product="bisphosphate 3'-nucleotidase"
/protein_id="AAD17329.1"
/translation="MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCAT
DLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPS
QYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAG
PDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRV
GGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDV
KHMNSAGVLATLRNYDYYASRVPESIKNALVP"
BASE COUNT 605 a 412 c 506 g 590 t
ORIGIN
1 ggaattcggc acgagaagct cggtactgga cacaacgagg gacctgggtc tacgataacg
61 cgcttttgct cctcctgaag tgtctttggt ccaacgttgt tccagagtgt accatggctt
121 ccagtaacac tgtgttgatg cggttggtag cctccgcata ttctattgct caaaaggcag
181 gaatgatagt cagacgtgtt attgctgaag gagacctggg tattgtggag aagacctgtg
241 caacagacct gcagaccaaa gctgaccgat tggcacagat gagcatatgt tcttcattgg
301 cccggaaatt ccccaaactc acaattatag gggaagagga tctgccttct gaggaagtgg
361 atcaagagct gattgaagac agtcagtggg aagaaatact gaagcaacca tgcccatcgc
421 agtacagtgc tattaaagaa gaagatctcg tggtctgggt tgatcctctg gatggaacca
481 aggaatatac cgaaggtctt cttgacaatg taacagttct tattggaatt gcttatgaag
541 gaaaagccat agcaggagtt attaaccagc catattacaa ctatgaggca ggaccagatg
601 ctgtgttggg gaggacaatc tggggagttt taggtttagg cgcctttggg tttcagctga
661 aagaagtccc tgctgggaaa cacattatca caactactcg atcccatagc aacaagttgg
721 ttactgactg tgttgctgct atgaaccccg atgctgtgct gcgagtagga ggagcaggaa
781 ataagattat tcagctgatt gaaggcaaag cctctgctta tgtatttgca agtcctggtt
841 gtaagaagtg ggatacttgt gctccagaag ttattttaca tgctgtggga ggcaagttaa
901 ccgatatcca tgggaatgtt cttcagtacc acaaggatgt gaagcatatg aactctgcag
961 gagtcctggc cacactgagg aattatgact actatgcaag ccgagttcca gaatctatta
1021 aaaatgcact tgttccttaa aggaaagttt catttggccg ggcgcggtgg ctcatgcctg
1081 taatcccagc actttgggag gccgaggcag gtggatcact tgagctcagg agtttgagac
1141 cagcctgggc aatatcgtga gaccccatct ctacaaaaat acaaattaac tgggcatcct
1201 gtcatgcgcc tgtcatccca gctacttgag aggctgaagc agaagaatct cttgagcccg
1261 gaaggcggag gttgcagtga gctgagatcg tgccactgca ctccagcctg agtgacagga
1321 gttaagccct gtctcagaaa aaaaacataa acccaaaaag tacttaaagt ttcatttact
1381 tactaggaaa agacttggtt ctcaaataat acattttaag attaattggg tagaattaga
1441 gttccacctt tatcattgtt gacagtgatt tatatttagt tatatattta gaataaaaat
1501 taactaaata atttaacttg attaatacca ttactcaacc tgacaattga gttggagact
1561 tataaactca ttatggttat catgtgtttt cctgttgaat gtgaagaagt gagaaaacat
1621 ttgccaatga cagttaggcg tgcacactga ccattcactg ataaaccaga ttctgcctga
1681 atctgaaggg attgcttgta gcatagggtt tagtggcgtg atcttgggtc actgcggccc
1741 gcttccgggg ttcatgcttc tcctgcctag ctccgggtag ctgggactgc agcacggccc
1801 acgctggtaa ttttttgtat gatggtgaga agttttcacc gtgttgccag gatggcttat
1861 cctgacatcg tgatctgtat gcctcggatc ccaaagtgca tgggatgaca gctgtgagcc
1921 accgcacttg gcttaaacca gatttcttta gggcacattt ttttggaatc tcactctgtt
1981 tttcacagta attttaaaaa cgttttatcc aattagaata tatatgatgt tattatatat
2041 gcttatgaaa cagatttatg agaaaagttt tttttaaata aattatttaa tccctaaaaa
2101 aaaaaaaaaa aaa
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