LOCUS SIU02546.1 619 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx
conserved component ecca2. esx-2 type vii secretion system
protein. probable cbxx/cfqx family protein. protein.
ACCESSION LT708304-3960
PROTEIN_ID SIU02546.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="ecca2"
/locus_tag="BQ2027_MB3914C"
/note="Mb3914c, -, len: 619 aa. Equivalent to Rv3884c,
len: 619 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.8% identity in 619 aa overlap). Putative CBXX/CFQX
protein family, similar to hypothetical proteins from
Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640
aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95%
identity in 587 aa overlap);
O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE
CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA
scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa
overlap). Also similar to proteins belonging to the
CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX
FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA
scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa
overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V
SPORULATION PROTEIN K from Bacillus subtilis (322 aa)
FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in
280 aa overlap) (similarity only at C-terminus);
Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus
halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19,
(36.05% identity in 244 aa overlap) (similarity only at
C-terminus); etc. And similar to hypothetical proteins
from Mycobacterium tuberculosis belonging to the CBXX/CFQX
FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10
HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt:
743, E(): 2.6e-35, (29.9% identity in 612 aa overlap);
O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL
62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E():
1.3e-31, (31.25% identity in 589 aa overlap);
O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA
scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY.
Mb3914c found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing (TPM > 20)."
/db_xref="GOA:P59976"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="UniProtKB/Swiss-Prot:P59976"
BEGIN
1 MSRMVDTMGD LLTARRHFDR AMTIKNGQGC VAALPEFVAA TEADPSMADA WLGRIACGDR
61 DLASLKQLNA HSEWLHRETT RIGRTLAAEV QLGPSIGITV TDASQVGLAL SSALTIAGEY
121 AKADALLANR ELLDSWRNYQ WHQLARAFLM YVTQRWPDVL STAAEDLPPQ AIVMPAVTAS
181 ICALAAHAAA HLGQGRVALD WLDRVDVIGH SRSSGRFGAD VLTAAIGPAD IPLLVADLAY
241 VRGMVYRQLH EEDKAQIWLS KATINGVLTD AAKEALADPN LRLIVTDERT IASRSDRWDA
301 STAKSRDQLD DDNAAQRRGE LLAEGRELLA KQVGLAAVKQ AVSALEDQLE VRMMRLEHGL
361 PVEGQTNHML LVGPPGTGKT TTAEALGKIY AGMGIVRHPE IREVRRSDFC GHYIGESGPK
421 TNELIEKSLG RIIFMDEFYS LIERHQDGTP DMIGMEAVNQ LLVQLETHRF DFCFIGAGYE
481 DQVDEFLTVN PGLAGRFNRK LRFESYSPVE IVEIGHRYAT PRASQLDDAA REVFLDAVTT
541 IRNYTTPSGQ HGIDAMQNGR FARNVIERAE GFRDTRVVAQ KRAGQPVSVQ DLQIITATDI
601 DAAIRSVCSD NRDMAAIVW
//