LOCUS SIU02546.1 619 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx conserved component ecca2. esx-2 type vii secretion system protein. probable cbxx/cfqx family protein. protein. ACCESSION LT708304-3960 PROTEIN_ID SIU02546.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ecca2" /locus_tag="BQ2027_MB3914C" /note="Mb3914c, -, len: 619 aa. Equivalent to Rv3884c, len: 619 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 619 aa overlap). Putative CBXX/CFQX protein family, similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95% identity in 587 aa overlap); O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa overlap). Also similar to proteins belonging to the CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V SPORULATION PROTEIN K from Bacillus subtilis (322 aa) FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in 280 aa overlap) (similarity only at C-terminus); Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19, (36.05% identity in 244 aa overlap) (similarity only at C-terminus); etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CBXX/CFQX FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 743, E(): 2.6e-35, (29.9% identity in 612 aa overlap); O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL 62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E(): 1.3e-31, (31.25% identity in 589 aa overlap); O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY. Mb3914c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P59976" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR023835" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR041627" /db_xref="UniProtKB/Swiss-Prot:P59976" BEGIN 1 MSRMVDTMGD LLTARRHFDR AMTIKNGQGC VAALPEFVAA TEADPSMADA WLGRIACGDR 61 DLASLKQLNA HSEWLHRETT RIGRTLAAEV QLGPSIGITV TDASQVGLAL SSALTIAGEY 121 AKADALLANR ELLDSWRNYQ WHQLARAFLM YVTQRWPDVL STAAEDLPPQ AIVMPAVTAS 181 ICALAAHAAA HLGQGRVALD WLDRVDVIGH SRSSGRFGAD VLTAAIGPAD IPLLVADLAY 241 VRGMVYRQLH EEDKAQIWLS KATINGVLTD AAKEALADPN LRLIVTDERT IASRSDRWDA 301 STAKSRDQLD DDNAAQRRGE LLAEGRELLA KQVGLAAVKQ AVSALEDQLE VRMMRLEHGL 361 PVEGQTNHML LVGPPGTGKT TTAEALGKIY AGMGIVRHPE IREVRRSDFC GHYIGESGPK 421 TNELIEKSLG RIIFMDEFYS LIERHQDGTP DMIGMEAVNQ LLVQLETHRF DFCFIGAGYE 481 DQVDEFLTVN PGLAGRFNRK LRFESYSPVE IVEIGHRYAT PRASQLDDAA REVFLDAVTT 541 IRNYTTPSGQ HGIDAMQNGR FARNVIERAE GFRDTRVVAQ KRAGQPVSVQ DLQIITATDI 601 DAAIRSVCSD NRDMAAIVW //