LOCUS SIU02122.1 202 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 dtdp-
4-dehydrorhamnose 3,5-epimerase rmlc (dtdp-4-keto-6-deoxyglucose
3,5-epimerase) (dtdp-l-rhamnose synthetase) (thymidine
diphospho-4-keto-rhamnose 3,5-epimerase) protein.
ACCESSION LT708304-3536
PROTEIN_ID SIU02122.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="rmlC"
/locus_tag="BQ2027_MB3494"
/standard_name="rfbC"
/note="Mb3494, rmlC, len: 202 aa. Equivalent to Rv3465,
len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 202 aa overlap). Probable rmlC
(alternate gene name: rfbC), dtdp-4-dehydrorhamnose
3,5-epimerase (EC 5.1.3.13), nearly identical to
O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis
(203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5%
identity in 200 aa overlap) (previously known as rfbC).
Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE
DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium
leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,
(75.4% identity in 199 aa overlap). Also highly similar to
others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis
(198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3%
identity in 193 aa overlap); Q9L6C5 from Streptomyces
antibioticus (202 aa), FASTA scores: opt: 665, E():
1.8e-37, (49.25% identity in 197 aa overlap);
P29783|STRM_STRGR from Streptomyces griseus (200 aa),
FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in
201 aa overlap); Q54265|STRM from Streptomyces glaucescens
(200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7%
identity in 197 aa overlap); etc. Also highly similar to
Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from
Streptomyces fradiae (205 aa), FASTA scores: opt: 625,
E(): 8.6e-35, (45.9% identity in 194 aa overlap). Protein
product from Mb3494 detected using shotgun mass
spectrometry and SWATH mass spectrometry. Mb3494 found to
be expressed during exponential growth in Sauton's minimal
media by RNA-sequencing."
/db_xref="GOA:A0A1R3Y4B1"
/db_xref="InterPro:IPR000888"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR014710"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y4B1"
BEGIN
1 MKARELDVPG AWEITPTIHV DSRGLFFEWL TDHGFRAFAG HSLDVRQVNC SVSSAGVLRG
61 LHFAQLPPSQ AKYVTCVSGS VFDVVVDIRE GSPTFGRWDS VLLDDQDRRT IYVSEGLAHG
121 FLALQDNSTV MYLCSAEYNP QREHTICATD PTLAVDWPLV DGAAPSLSDR DAAAPSFEDV
181 RASGLLPRWE QTQRFIGEMR GT
//